A5000652199- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Carbon Nanotubes in Composites
- Heat shock proteins research
- Gas Sensing Nanomaterials and Sensors
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Renal and related cancers
- CRISPR and Genetic Engineering
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Genomics and Phylogenetic Studies
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Graphene research and applications
- Lung Cancer Diagnosis and Treatment
- Luminescence and Fluorescent Materials
- Endoplasmic Reticulum Stress and Disease
- Growth Hormone and Insulin-like Growth Factors
- Molecular Sensors and Ion Detection
Beijing University of Technology
2018-2025
South China University of Technology
2014-2025
Southwest University
2024-2025
Dazhou Central Hospital
2025
Shenzhen Third People’s Hospital
2023-2024
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Tianjin Medical University General Hospital
2024
Nanjing Medical University
2024
Fudan University
2010-2023
An ideal composite film based on a carbon nanotube (CNT) array for thermal management applications is prepared using "in-situ injection molding". The aligned CNTs with their tips protruding out of both surfaces form conducting paths between surfaces. Much better conductivity improvements can be achieved at low CNT loadings compared dispersed composites.
DNA hydroxymethylation and its mediated demethylation are critical for multiple cellular processes, example, nuclear reprogramming, embryonic development, many diseases. Here, we demonstrate that a vital nutrient ascorbic acid (AA), or vitamin C (Vc), can directly enhance the catalytic activity of Tet dioxygenases oxidation 5-methylcytosine (5mC). As evidenced by changes in intrinsic fluorescence Tet2 protein caused AA oxidation-resistant derivatives, further show uniquely interact with...
N6-Methyladenosine (m6A) is the most prevalent internal modification that occurs in mRNA of eukaryotes and plays a vital role post-transcriptional regulation. Recent studies highlighted biological significance m6A nervous system, its dysregulation has been shown to be related degenerative neurodevelopmental diseases. Parkinson's disease (PD) common age-related neurological disorder with pathogenesis still not fully elucidated. Reports have epigenetic mechanisms including DNA methylation...
In this study, the gas-sensitive response of metal (Ag, Au, Pt)-modified SnS2 toward SF6 decomposition gases (SOF2, SO2F2, SO2, H2S) in gas-insulated switchgear was studied by analyzing adsorption structure, band charge transfer, and density states based on functional theory. The results show that four target pristine belongs to weak physical adsorption. Compared with SnS2, energy transition atom-modified monolayer has been improved a certain extent capacity these obviously improved....
To evaluate the value of serum midkine (MDK) as a diagnostic biomarker in hepatocellular carcinoma, particularly for those with negative alpha-fetoprotein (AFP) and at an early stage.
DNA methylation has been proven to be a critical epigenetic mark important for various cellular processes. Here, we report that redox-active quinones, ubiquitous class of chemicals found in natural products, cancer therapeutics and environment, stimulate the conversion 5mC 5hmC vivo, increase 5751 genes cells. is associated with significantly altered gene expression 3414 genes. Interestingly, quinone-treated cells, labile iron-sensitive protein ferritin light chain showed significant at both...
Abstract Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T tumor chimeric antigen receptor- or bispecific cell-engaging are two typical cancer immunotherapy approaches. We speculated that immobilizing types mAbs against on a single nanoparticle could integrate functions these approaches, as engineered formulation (immunomodulating nano-adaptor, imNA) potentially associate with both bridge them together like an ‘adaptor’ while...
Background Information on fetal risks with maternal seizures during pregnancy is scarce. This study investigates seizure control and associated in different stages of among pregnant women epilepsy (PWWE). Methods The nested case–control enrolled PWWE between 2009 2023 China. was obtained seizures, antiseizure medication (ASM), folic acid supplementation outcomes. primary outcome composite including major congenital malformations (MCMs), neurodevelopmental delay, low birth weight (LBW) death....
A systematic study of the transition metal-catalyzed reaction enynal/enynone with alkenes has been reported. It was found that two metal-dependent pathways. One led to formation 1,2-DHN, while another cyclic-o-QDM.
Abstract Activation of the phagocytosis macrophages to tumor cells is an attractive strategy for cancer immunotherapy, but effectiveness limited by fact that many express increased level anti‐phagocytic signals (e.g., CD47 molecules) on their surface. To promote macrophages, a pro‐phagocytic nanoparticle (SNPA CALR&aCD47 ) concurrently carries antibody (aCD47) and molecule calreticulin (CALR) constructed simultaneously modulate phagocytic macrophages. SNPA can achieve targeted delivery...
Methyltransferase N6‑adenosine (METTL5) is a methyltransferase that specifically catalyzes 18S rRNA N6 methylation at adenosine 1832 (m6A1832), which located in critical position the decoding center, therefore suggesting its potential importance regulation of translation. However, underlying mechanism METTL5‑mediated translation specific genes and biological functions are largely undefined. To best our knowledge, present study demonstrated for first time METTL5 was an oncogene promoted cell...
Pancreatic cancer (PC) is one of the most aggressive and devastating types owing to its poor prognosis deadly characteristics. It well established that aberrations in expression key regulatory genes, namely tumor suppressors oncogenes, predispose patients progression metastasis PC. Upregulation Williams‑Beuren syndrome chromosomal region 22 (WBSCR22) expression, a ribosomal biogenesis factor, has been reported multiple human cancer. However, role WBSCR22 underlying mechanism PC have not...
Arrays of alumina nanopillars with adjustable dimensions (see Figure for a representative example) are fabricated by simple chemical etching porous anodic dilute NaOH. The diameter and height the pillars, as well interpillar spacing, function oxide layer thickness, which is controlled anodizing time voltage.
<h3>Background/aims</h3> The pathogenesis of BPD is multifactorial. In preterm infants ≤28 wk GA requiring ventilation at 7–14 days, >60% have surfactant dysfunction. Survival without in these <25%. Inhaled nitric oxide (iNO) may improve outcome some (Schreiber, NEJM 2003, Ballard NEJM, 2006). <h3>Methods</h3> Preterm mechanical days were enrolled a RCT 25 US centres. All received iNO and randomised to receive (Infasurf) or sham instillation behind screen every 1–2 days; maximum 5...
Osteopontin (OPN) plays an important role in the development, invasion, and metastasis of malignancies. Recently, several studies have reported that OPN enhances chemoresistance small-cell lung cancer breast by blocking caspase-9 caspase-3-dependent cell apoptosis. The aim this study was to assess value caspase-3 for predicting tumor recurrence after curative resection hepatocellular carcinoma (HCC) patients. We found expression increased concordantly with increasing metastatic potential...
Sall4 (Splat-like 4) plays important roles in maintaining pluripotency of embryonic stem cells and various developmental processes. Here, we find that is highly expressed oocytes early embryos. To investigate the SALL4 oogenesis, generated maternal specific knock-out mice by using CRISPR/Cas9 system, deletion causes arrest at germinal vesicle stage with non-surrounded nucleus, subsequent meiosis resumption prohibited. We further discover loss failure establishment DNA methylation oocytes....