A5073884535- Mesenchymal stem cell research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Peroxisome Proliferator-Activated Receptors
- Peptidase Inhibition and Analysis
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Adenosine and Purinergic Signaling
- Liver Disease Diagnosis and Treatment
- Renal and related cancers
- Microtubule and mitosis dynamics
- Lipid metabolism and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
Beijing University of Technology
2017-2025
Beijing Jiaotong University
2022
Chinese Academy of Sciences
2015-2018
Institute of Biophysics
2015-2018
Academy of Military Medical Sciences
2009-2010
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2010
It is highly desirable and a great challenge for red light emission of carbon dots under long wavelength excitation. Here, we developed facile route to synthesize with due the doping effect S N elements, borrowing from concept semiconductor. The maximum locates at 594 nm 560 absolute photoluminescence (PL) quantum yield (QY) as high 29% 22% in ethanol water, respectively. XPS FTIR spectra illustrated that there exist -SCN -COOH groups on surface dots. They endow sensitivity ion detection...
Intrahepatic cholangiocarcinoma (ICC) is the second most common liver malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal reaction. Therefore, comprehensive understanding of diversity interplay between malignant cells niche essential to elucidate mechanisms driving progression develop therapeutic approaches.Herein, we performed single-cell RNA sequencing (scRNA-seq) analysis on unselected viable from 8 human ICCs adjacent samples transcriptomic landscape...
Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC) contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant expression long noncoding RNAs (lncRNA) has been associated with these processes but cellular mechanisms are obscure. In this study, we report HCC-associated (HCC-MSC) promote epithelial-mesenchymal transition (EMT) liver tumorigenesis. We identified a novel lncRNA termed lncRNA-MUF (MSC-upregulated factor) is highly...
Cervical squamous cell carcinoma (CESC) is a prototypical human cancer with well-characterized pathological stages of initiation and progression. However, high-resolution knowledge the transcriptional programs underlying each stage CESC lacking, important questions remain. We performed single-cell RNA sequencing 76,911 individual cells from 13 samples cervical tissues at various malignancy, illuminating tumorigenic trajectory epithelial revealing key factors involved in In addition, we found...
Cancer-associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer-associated MSCs (LC-MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified presence of HCC tissues. We also showed that LC-MSCs significantly enhanced growth vivo promoted sphere formation vitro. metastasis an orthotopic transplantation model. Complementary DNA (cDNA) microarray analysis S100A4 expression was higher...
Up to now, the gingiva-derived mesenchymal stem cells (GMSCs) as a new postnatal have been isolated and characterized with multipotential differentiation capabilities in vitro. However, vivo efficacy of utilizing GMSCs bone regeneration remains obscure. First all, we identified canonical MSCs human gingival tissue, which possessed homogenous immunophenotype (CD34−CD45−CD29+CD105+CD90+ STRO-1+) had tri-lineage potential (osteoblasts, adipocytes, chondrocytes). Next, examined these tissue...
Liver cancer stem cells (CSCs) have been identified and shown to self-renewal differentiation properties; however, the biology of these hepatic CSCs remains largely unknown. Here, we analyzed transcriptome gene expression profiles liver non-CSCs from hepatocellular carcinoma (HCC) lines found that transcription factor (TF) ZIC2 is highly expressed in CSCs. was required for maintenance CSCs, as depletion reduced sphere formation xenograft tumor growth mice. We determined acts upstream TF OCT4...
Emerging evidence suggests that epithelial‐mesenchymal transitions (EMTs) play important roles in tumor metastasis and recurrence. Understanding molecular mechanisms regulate the EMT process is crucial for improving treatment of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) HCC; however, by which miRNAs target their therapeutic potential remains largely unknown. To better explore process, we established an model HCC cells transforming growth factor beta 1 found several tumor‐related...
Abstract Liver cancer stem cells (CSCs) harbour self-renewal and differentiation properties, accounting for chemotherapy resistance recurrence. However, the molecular mechanisms to sustain liver CSCs remain largely unknown. In this study, based on analysis of several hepatocellular carcinoma (HCC) transcriptome datasets our experimental data, we find that C8orf4 is weakly expressed in HCC tumours CSCs. attenuates capacity tumour propagation. We show NOTCH2 activated located cytoplasm...
Abstract Despite significant advancements in identifying novel therapeutic targets and compounds, cancer stem cells (CSCs) remain pivotal driving resistance tumor progression gastric (GC). High‐resolution knowledge of the transcriptional programs underlying role CSC niche stemness is still lacking. Herein, spatial single‐cell RNA sequencing 32 human mucosa tissues at various stages malignancy, illuminating phenotypic plasticity epithelium trajectory from mature chief to state, which...
The high incidence rate of hepatocellular carcinoma (HCC) is mainly the result frequent metastasis and tumor recurrence. Unfortunately, underlying molecular mechanisms driving HCC are still not fully understood. It has been demonstrated that stroma cells contribute to primary growth metastasis. Within environment, activated hepatic stellate (HSCs) can release a number molecules enhance cancer cell proliferation invasiveness in paracrine manner. Here, for first time, we demonstrate epimorphin...
Abstract Accumulating evidence suggests that Ras GTPase‐activating protein SH3 domain‐binding 1 (G3BP1) is very crucial to regulate tumorigenesis and metastasis. Recently, many research works have suggested G3BP1 overexpressed in human cancers including esophageal cancer. Nevertheless, the functional roles of cancer are still unknown. Here, results silencing inhibited proliferation, migration, invasion cells, whereas overexpression led opposite effects on growth Surprisingly, G3BP1‐depletion...
Abstract Background Altered lipid metabolism is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) a member CPT1 family plays key role in cancer progression. However, how microRNAs (miRNAs) regulate CPT1C-mediated fatty acid transport oxidation remains be elucidated. Methods Oil Red O staining, mitochondrial, droplets immunofluorescence staining were used detect functions miR-377-3p CPT1C oxidation. Colocalization...
Tolerogenic dendritic cells (tolDCs) facilitate the suppression of autoimmune responses by differentiating regulatory T (Treg). The dysfunction immunotolerance results in development diseases, such as rheumatoid arthritis (RA). As multipotent progenitor cells, mesenchymal stem (MSCs), can regulate (DCs) to restore their immunosuppressive function and prevent disease development. However, underlying mechanisms MSCs regulating DCs still need be better defined. Simultaneously, delivery system...
SPINDLIN1, a new member of the SPIN/SSTY gene family, was first identified as highly expressed in ovarian cancer cells. We have previously shown that it is involved process spindle organization and chromosomal stability plays role development cancer. Nevertheless, mechanisms underlying its oncogenic are still largely unknown. Here, we showed expression SPINDLIN1 upregulated clinical tumors. Ectopic promoted cell proliferation activated WNT/T-cell factor (TCF)-4 signaling. The Ser84 Ser99...
Neural stem cells (NSCs) are critical for brain development and maintenance of neurogenesis. However, the molecular mechanisms that regulate NSC proliferation differentiation remain unclear. Mysm1 is a deubiquitinase essential self-renewal several cells. It unknown whether plays an important role in NSCs. Here, we found was expressed NSCs its expression increased with age mice. Mice knockdown by crossing floxed mice Nestin-Cre exhibited abnormal microcephaly. deletion promoted apoptosis,...
Abstract Temporal and spatial-specific regulation of pluripotency networks is largely dependent on the precise modifications core transcription factors. Misregulation glutamylation implicated in severe physiological abnormalities. However, how regulates cell reprogramming remains elusive. Here we show that cytosolic carboxypeptidases 1 (CCP1) or CCP6 deficiency substantially promotes induced pluripotent (iPSC) induction embryonic stem cells (ESCs). Klf4 polyglutamylation at Glu381 by tubulin...
Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Molecular hydrogen has been considered a preventive and therapeutic medical gas in many diseases including cancer. In our study, we sought to assess potential role molecular on GBM. The vivo studies were performed using rat orthotopic glioma model mouse subcutaneous xenograft model. Animals inhaled (67%) 1 h two times per day. MR imaging determine tumor volume. Immunohistochemistry (IHC), immunofluorescence...