A5100415539- Neuroinflammation and Neurodegeneration Mechanisms
- Bone health and treatments
- Neuroscience and Neuropharmacology Research
- Bone Metabolism and Diseases
- Eicosanoids and Hypertension Pharmacology
- Cholinesterase and Neurodegenerative Diseases
- Piperaceae Chemical and Biological Studies
- S100 Proteins and Annexins
- Adenosine and Purinergic Signaling
- Neurological Disease Mechanisms and Treatments
- Sulfur Compounds in Biology
- Peroxisome Proliferator-Activated Receptors
- Nerve injury and regeneration
- Nanopore and Nanochannel Transport Studies
- Medicinal Plants and Neuroprotection
- Neurological Disorders and Treatments
- Bone health and osteoporosis research
- Spinal Cord Injury Research
- Cancer, Stress, Anesthesia, and Immune Response
- Mesenchymal stem cell research
- Nuclear Receptors and Signaling
- Parasitic infections in humans and animals
- GDF15 and Related Biomarkers
- Sesquiterpenes and Asteraceae Studies
- Histone Deacetylase Inhibitors Research
Shandong University of Traditional Chinese Medicine
2018-2025
Peking University First Hospital
2022-2025
Peking University
2022-2025
University Hospital of Zurich
2023-2024
University of Zurich
2023-2024
Guangxi Medical University
2021-2023
Xiamen Medical College
2023
First Affiliated Hospital of GuangXi Medical University
2021-2023
Binzhou University
2023
Binzhou Medical University
2023
Rationale: Mesenchymal stromal cells (MSCs) are emerging as a novel therapeutic strategy for the acute ischemic stroke (AIS).However, poor targeted migration and low engraftment in lesions restrict their treatment efficacy.The brain express specific chemokine profile, while cultured MSCs lack set of corresponding receptors.Thus, we hypothesize that overexpression certain receptor might help homing improve efficacy.Methods: Using middle cerebral artery occlusion (MCAO) model stroke,...
Small extracellular vesicles (sEVs; <200 nm) that contain lipids, nucleic acids, and proteins are considered promising biomarkers for a wide variety of diseases. Conventional methods sEV isolation from blood incompatible with routine clinical workflows, significantly hampering the utilization blood-derived sEVs in settings. Here, we present simple, viscoelastic-based microfluidic platform label-free human blood. The separation performance device is assessed by isolating fluorescent whole...
The binding of endothelin-1 (ET-1) to endothelin type A receptor (ETAR) performs a critical action in pulmonary arterial smooth muscle cell (PASMC) proliferation leading vascular structural remodeling. More evidence showed that cystathionine γ-lyase (CSE)-catalyzed endogenous hydrogen sulfide (H2S) was involved the pathogenesis cardiovascular diseases. In this study, we aimed explore effect H2S/CSE pathway on ET-1/ETAR and its underlying mechanisms cellular animal models PASMC proliferation....
Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson's disease (PD) pathogenesis. However, molecular mechanisms which α-syn exerts neuroinflammation and neurotoxicity remain largely elusive. Targeting metabotropic glutamate receptor 5 (mGluR5) has been an attractive strategy to mediate microglia for neuroprotection, might be essential regulator modulate α-syn-induced treatment PD. Here, we showed that mGluR5 inhibited inflammation protect from...
Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system (CNS) that causes irreversible damage to tissue. The consequent hemorrhage contributed by trauma induces neuronal ferroptosis post SCI, which an important death mode mediate loss. Growth differentiation factor 15 (GDF15) cytokine regulates cell proliferation, differentiation, and death. However, specific role GDF15 in SCI remains unknown.Neuronal vitro was measured detection lipid peroxidation, glutathione,...
Abstract Background Altered lipid metabolism is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Carnitine palmitoyltransferase 1C (CPT1C) a member CPT1 family plays key role in cancer progression. However, how microRNAs (miRNAs) regulate CPT1C-mediated fatty acid transport oxidation remains be elucidated. Methods Oil Red O staining, mitochondrial, droplets immunofluorescence staining were used detect functions miR-377-3p CPT1C oxidation. Colocalization...
Plants suffer from various abiotic stresses during their lifetime, of which drought and salt are two main factors limiting crop yield quality. Previous studies have shown that abscisic acid (ABA) responsive element binding protein (AREB)/ ABRE (ABFs) in bZIP transcription involved plant stress response an ABA-dependent manner. However, little is known about the properties functions AREB/ABFs, especially ABF3, cotton.Here, we reported cloning characterization GhABF3. Expression GhABF3 was...
Traumatic spinal cord injury (SCI)-induced neuroinflammation results in secondary neurological destruction and functional disorder. Previous findings showed that microglial pyroptosis plays a crucial role neuroinflammation. Thus, it is necessary to conduct comprehensive investigation of the mechanisms associated with post-SCI pyroptosis. The Fanconi Anemia Group C complementation group gene (FANCC) has been previously reported have an anti-inflammation effect; however, whether can regulate...
Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level lower developing PD. However, mechanistic basis for this association remains unclear. Urate protects dopaminergic neurons from cell death induced by stress. Here, we investigated novel role in microglia activation lipopolysaccharide (LPS)-induced PD model.We utilized Griess, ELISA, real-time PCR,...
Oleoylethanolamide (OEA) has been demonstrated to be a feasible protectant in ischemic stroke. However, the mechanism for OEA-afforded neuroprotection remains elusive. The present study aimed investigate neuroprotective effects of OEA on peroxisome proliferator-activated receptor α (PPARα)-mediated microglia M2 polarization after cerebral ischemia. Transient middle artery occlusion (tMCAO) was induced 1 h wild-type (WT) or PPARα-knock-out (KO) mice. Mouse small glioma cells (BV2) and primary...
We present an ultrahigh-throughput, real-time fluorescence cytometer comprising a viscoelastic microfluidic system and complementary metal–oxide-semiconductor (CMOS) linear image sensor-based detection system. The flow allows for quantification of variety species, including micrometer-sized particles cells, at analytical throughputs in excess 400,000 species per second. platform integrates custom C++ control program graphical user interface (GUI) to allow the processing raw signals,...
Aims: Prostate cancer is a well-known aggressive malignant tumor in men with high metastasis rate and poor prognosis. Adapalene (ADA) third-generation synthetic retinoid anticancer properties. We investigated the anti-tumor activity molecular mechanisms of ADA RM-1 prostate cell line vivo vitro. Methods: The effects on proliferation were estimated using CCK-8 colony formation assays. wound-healing assay Transwell employed to examine migratory capacity invasiveness cells. Flow cytometry was...
Cognitive dysfunction after total knee arthroplasty (TKA) is very common in elderly patients. Postoperative cognitive (POCD), as a form of dysfunction, may affect patients' short- and long-term recoveries. The identification meaningful risk factors help reduce the occurrence POCD future.Our goal was to retrospectively investigate for early patients undergoing TKA further analyze relationship between intensity level function.The related indicators Montreal Function Assessment Scale (MOCA)...
Both hydrogen sulfide (H2S) and sulfur dioxide (SO2) are produced endogenously from the mammalian metabolic pathway of sulfur-containing amino acids play important roles in several vascular diseases. However, their interaction during control function has not been fully clear. Here, we investigated potential role H2S SO2 production regulation vivo vitro. Wistar rats were divided into vehicle, SO2, DL-propargylglycine (PPG) + β-cyano-L-alanine (BCA) sodium hydrosulfide (NaHS) groups. donor was...
Background The aim of this study was to explore clinical features and potential mechanisms relating neuropathological biomarkers blood-brain barrier (BBB) in Alzheimer’s disease (AD) hearing loss (HL). Materials Methods A total 65 patients with AD were recruited auditory function assessed by threshold pure tone audiometry (PTA). Patients divided into HL (AD-HL) no (AD-nHL) groups based on the standard World Health Organization. Clinical symptoms multiple rating scales. levels β amyloid1-42...
The death of spinal motor neurons (SMNs) after cord injury (SCI) is a crucial cause, contributing to permanent neurological deficit. Total flavonoids hawthorn leaves (TFHL) have been confirmed potentially therapeutic for SCI. Nonetheless, the roles and mechanisms TFHL in recovering neuromotor function regenerating axons SMNs not fully elucidated. In this study, was applied treat rats with SCI injured 7 days. vivo experiment, were evaluated by BBB (Basso-Beattie-Bresnahan) score assess their...
The development and maintenance of normal bone tissue is maintained by balanced communication between osteoblasts osteoclasts. invasion cancer cells disrupts this balance, leading to osteolysis. As the only resorbing in vivo, osteoclasts play important roles cancer-induced However, role 3-phosphoinositide-dependent protein kinase-1 (PDK1) osteoclast resorption remains unclear. In our study, we used a receptor activator nuclear factor-kappa B (RANK) promoter-driven Cre-LoxP system...