A5015080274- Cardiac electrophysiology and arrhythmias
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Neuroscience and Neural Engineering
- Ion channel regulation and function
- Hormonal Regulation and Hypertension
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Renin-Angiotensin System Studies
- Sirtuins and Resveratrol in Medicine
- Angiogenesis and VEGF in Cancer
- Sulfur Compounds in Biology
- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Advanced Fluorescence Microscopy Techniques
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- Diabetes Treatment and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiomyopathy and Myosin Studies
Chinese University of Hong Kong
2016-2025
Saarland University
2016-2025
Guangzhou University of Chinese Medicine
2022-2025
Ministry of Education of the People's Republic of China
2012-2025
Peking University First Hospital
2016-2025
Peking University
2012-2025
Chinese University of Hong Kong, Shenzhen
2014-2025
Kleijnen Systematic Reviews (United Kingdom)
2024-2025
Henan Normal University
2025
Wuhan Polytechnic University
2024
In this article, we first designed and synthesized curcumin-based near-infrared (NIR) fluorescence imaging probes for detecting both soluble insoluble amyloid beta (Aβ) species then an inhibitor that could attenuate cross-linking of Aβ induced by copper. According to our previous results the possible structural stereohindrance compatibility peptide hydrophobic/hydrophilic property Aβ13-20 (HHQKLVFF) fragment, NIR probe CRANAD-58 was synthesized. As expected showed significant changes upon...
Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring therapy of cancer and other diseases in preclinical studies; however, this technology not successfully for Alzheimer's disease (AD). Although several NIRF probes detecting amyloid beta (Aβ) species AD have reported, none these used monitor changes Aβs during therapy. In article, we demonstrated that CRANAD-3, a curcumin analog, is capable both soluble insoluble Aβ species. vivo showed the signal...
Abstract The epicardium, the mesothelial envelope of vertebrate heart, is source multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth repair. Here we generate self-organizing human pluripotent stem cell-derived epicardioids display retinoic acid-dependent morphological, molecular functional patterning epicardium myocardium typical left ventricular wall. By combining lineage tracing, single-cell transcriptomics chromatin...
The binding of endothelin-1 (ET-1) to endothelin type A receptor (ETAR) performs a critical action in pulmonary arterial smooth muscle cell (PASMC) proliferation leading vascular structural remodeling. More evidence showed that cystathionine γ-lyase (CSE)-catalyzed endogenous hydrogen sulfide (H2S) was involved the pathogenesis cardiovascular diseases. In this study, we aimed explore effect H2S/CSE pathway on ET-1/ETAR and its underlying mechanisms cellular animal models PASMC proliferation....
Sitagliptin, a selective dipeptidyl peptidase 4 inhibitor, inhibits the inactivation and degradation of glucagon like peptide 1 (GLP-1), which is used for treatment type 2 diabetes mellitus. However, little known about role GLP-1 in hypertension. This study investigated whether activation signaling protects endothelial function Two-week sitagliptin (10 mg/kg per day, oral gavage) improved endothelium-dependent relaxation renal arteries, restored blood flow, reduced systolic pressure...
5' Adenosine monophosphate-activated protein kinase (AMPK) interacts with peroxisome proliferator-activated receptor δ (PPARδ) to induce gene expression synergistically, whereas the activation of AMPK inhibits endoplasmic reticulum (ER) stress. Whether vascular benefits antidiabetic drug metformin (AMPK activator) in diabetes mellitus and obesity is mediated by PPARδ remains unknown. We aim investigate whether crucial for ameliorating ER stress endothelial dysfunction induced high-fat...
E-selectin is a surface marker of endothelial cell (EC) inflammation, one the hallmarks atherogenesis. Thus, we tested hypothesis that delivery microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector (ESTA-MSV) to inflamed endothelium covering atherosclerotic plaques inhibits atherosclerosis. Cy5-conjugated miR-146a were packaged in polyethylene glycol-polyethyleneimine (PEG/PEI) nanoparticles loaded into ESTA-MSV microparticles. Both miRs downregulated tumor necrosis...
Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action. However, the role of associated with diabetes obesity is unclear.UCP2 protects induced by high-fat diet through inhibition reactive oxygen species (ROS) production, subsequent increase nitric oxide bioavailability.Endothelium-dependent relaxation (EDR) aortae mesenteric arteries response to acetylcholine was...
Rationale: Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction hypertension remain elusive. Objective: To elucidate cellular pathways by which BMP4-induced is mediated through oxidative stress–dependent upregulation cyclooxygenase (COX)-2. Methods Results: Impaired endothelium-dependent relaxations, exaggerated contractions, reactive oxygen species...
AimsPathological cardiac hypertrophy is a major predictor for the development of diseases. It associated with chronic neurohumoral stimulation and altered Ca2+ signalling in cardiomyocytes. TRPC proteins form agonist-induced cation channels, but their functional role homeostasis cardiomyocytes during fast cytosolic cycling leading to unknown.
Abstract The molecular signatures of cells in the brain have been revealed unprecedented detail, yet ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction neurodegenerative diseases remain elusive. Here, we report zonation-dependent transcriptomic aged mouse endothelial (ECs), which prominently implicate altered immune/cytokine signaling ECs all vascular segments, and functional impacting blood–brain barrier (BBB) glucose/energy metabolism...
Cellular senescence is associated with pleiotropic physiopathological processes, including aging and age-related diseases. The persistent DNA damage a major stress leading to senescence, but the underlying molecular link remains elusive. Here, we identify La Ribonucleoprotein 7 (LARP7), 7SK RNA binding protein, as an antagonist. damage-mediated Ataxia Telangiectasia Mutated (ATM) activation triggers extracellular shuttling downregulation of LARP7, which dampens SIRT1 deacetylase activity,...
Abstract It is commonly accepted that the increased degree of graphitization leads to a higher electrical conductivity carbon materials. However, more and evidence reveals heteroatom doping on host can also improve conductivity, owing dopant atoms contributing charge delocalization density donor states near Fermi level. The reality is, such improvement from often overwhelmed by graphitized carbon. Although heteroatom‐doped widely used as active materials in fields energy storage...
Background: Inflamed endothelial cells (ECs) trigger atherogenesis, especially at arterial regions experiencing disturbed blood flow. UCP2 (Uncoupling protein 2), a key mitochondrial antioxidant protein, improves endothelium-dependent relaxation in obese mice. However, whether can be regulated by shear flow is unknown, and the role of regulating inflammation atherosclerosis remains unclear. This study aims to investigate mechanoregulation expression ECs effect on atherogenesis. Methods: In...
Robotic perception requires the modeling of both 3D geometry and semantics. Existing methods typically focus on estimating bounding boxes, neglecting finer geometric details struggling to handle general, out-of-vocabulary objects. occupancy prediction, which estimates detailed states semantics a scene, is an emerging task overcome these limitations. To support we develop label generation pipeline that produces dense, visibility-aware labels for any given scene. This comprises three stages:...