A5040630392- Liver Disease Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Interprofessional Education and Collaboration
- Alcohol Consumption and Health Effects
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- High Altitude and Hypoxia
- Eicosanoids and Hypertension Pharmacology
- Innovations in Medical Education
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Cancer, Hypoxia, and Metabolism
- Obstructive Sleep Apnea Research
- Perfectionism, Procrastination, Anxiety Studies
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Anatomy and Medical Technology
- Nitric Oxide and Endothelin Effects
- Oral and Maxillofacial Pathology
- Surgical Simulation and Training
- Palliative Care and End-of-Life Issues
- Autophagy in Disease and Therapy
- Garlic and Onion Studies
- Cancer-related molecular mechanisms research
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2008-2022
HKU-Pasteur Research Pole
2006-2022
Shenzhen Third People’s Hospital
2016
Dalhousie University
2008-2014
Jinan University
2014
Art Research Centre of the Slovak Academy of Sciences
2013
Hong Kong Association of Registered Tour Co-ordinators
2010
University of Pennsylvania
2004-2008
University of Nebraska Medical Center
2008
Retinitis pigmentosa (RP) is a photoreceptor-degenerative disease caused by various mutations and characterized death of rod photoreceptor cell followed gradual cone photoreceptors. The molecular mechanisms that lead to are not yet fully understood. Neuroinflammation contributes the progression many chronic neurodegenerative disorders. However, it remains be determined how microglia contribute disruption in RP. In this study, we explored role as contributor degeneration rd10 mouse model...
The increased susceptibility of the elderly to lower respiratory tract infection cannot be fully explained. Although mucociliary clearance, which is affected by ciliary beating and ultrastructure, plays a crucial role in defense airways against inhaled microbes, little known effects aging on these parameters. We studied nasal clearance (NMCC) time, beat frequency, ultrastructure cilia cohort healthy volunteers (age range 11 90 yr). Ciliary frequency ciliated epithelial cells was obtained via...
Induction of NF-kappaB-mediated gene expression has been implicated in the pathogenesis alcoholic liver disease (ALD). Curcumin, a phenolic antioxidant, inhibits activation NF-kappaB. We determined whether treatment with curcumin would prevent experimental ALD and elucidated underlying mechanism. Four groups rats (6 rats/group) were treated by intragastric infusion for 4 wk. One group received fish oil plus ethanol (FE); second dextrose (FD). The third fourth FE or FD supplemented 75 mg....
Rationale: Bone morphogenic protein (BMP)4 can stimulate superoxide production and exert proinflammatory effects on the endothelium. The underlying mechanisms of how BMP4 mediates endothelial dysfunction hypertension remain elusive. Objective: To elucidate cellular pathways by which BMP4-induced is mediated through oxidative stress–dependent upregulation cyclooxygenase (COX)-2. Methods Results: Impaired endothelium-dependent relaxations, exaggerated contractions, reactive oxygen species...
This study aimed to investigate the possible therapeutic effects and active components of Lycium barbarum polysaccharides (LBP) on a high fat diet-induced NASH rat model. We induced in model by voluntary oral feeding with high-fat diet ad libitum for 8 weeks. After weeks, 1 mg/kg LBP was orally administered another 4 weeks diet. When compared rats treated 12 treatment during induction showed ameliorative on: (1) increased body wet liver weights; (2) insulin resistance glucose metabolic...
Chlorine is widely used for disinfecting public swimming pool water. The disinfectant chlorine, protecting swimmers from pathogenic infection in swimming, may be responsible some adverse effects on swimmers' skin and health. In this study, numerous new halogenated disinfection byproducts (DBPs) chlorinated water were detected with a powerful precursor ion scan method using electrospray ionization triple quadrupole mass spectrometry, or without preseparation ultra performance liquid...
Hepatocellular carcinoma (HCC) is the fifth most common cancer in world and third leading cause of cancer-related death. Critical roles for long non-coding RNAs (lncRNAs) have recently been demonstrated a variety cancers, including hepatocellular carcinoma. However, effect mechanism lncRNAs HCC tumorigenesis chemoresistance not extensively characterized.In current study, we identified HCC-expressed lncRNA termed as HANR (HCC associated RNA). We by microarray analysis validated its...
The impact of the medical curricular reform on anatomy education has been inconclusive. A pervasive perception is that graduates do not possess a sufficient level anatomical knowledge for safe practice; however, reason less well-studied. This qualitative study investigated perceived challenges in learning anatomy, possible explanations, and ways to overcome these challenges. Unlike previous work, it explored perceptions multiple stakeholders learning. Semi-structured interviews were...
Alcoholic liver injury is more severe and rapidly developing in women than men. To evaluate the reason(s) for these gender-related differences, we determined whether pathogenic mechanisms important alcoholic male rats were further upregulated female rats. Male age-matched (7/group) fed ethanol a diet containing fish oil 4 wk by intragastric infusion. Dextrose isocalorically replaced control We analyzed histopathology, lipid peroxidation, cytochrome P-450 (CYP)2E1 activity, nonheme iron,...
The mechanism for the pathogenesis of H5N1 infection in humans remains unclear. This study reveals that cyclooxygenase-2 (COX-2) was strongly induced H5N1-infected macrophages vitro and epithelial cells lung tissue samples obtained during autopsy patients who died disease. Novel findings demonstrated COX-2, along with tumor necrosis factor α other proinflammatory cytokines were hyperinduced by secretory factors from vitro. amplification response is rapid, effects elicited H5N1-triggered...
To investigate the hepato-protective properties and underlying mechanisms of SAMC in a non-alcoholic fatty liver disease (NAFLD) rat model.Female rats were fed with diet comprising highly unsaturated fat (30% fish oil) for 8 weeks to develop NAFLD or without an intraperitoneal injection 200 mg/kg three times per week. After euthanasia, blood samples collected histological biochemical analyses.Co-treatment attenuated NAFLD-induced injury, accumulation, collagen formation free acids (FFAs). At...
Maladaptive changes in the carotid body (CB) induced by chronic intermittent hypoxia (IH) account for pathogenesis of cardiovascular morbidity patients with sleep-disordered breathing. We postulated that proinflammatory cytokines, namely interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α, cytokine receptors (IL-1r1, gp130 TNFr1) locally expressed rat CB play a pathophysiological role IH-induced inflammation. Results showed increased levels oxidative stress (serum 8-isoprostane...
The pathogenesis of hypertension in patients with obstructive sleep apnea (OSA) is associated endothelial dysfunction induced by chronic intermittent hypoxia (IH). Studies have shown that administration melatonin ameliorates oxidative injury and inflammation. This study examined the effect on stress, dysfunction, inflammation during IH. Adult Sprague-Dawley rats had received a daily injection or vehicle were exposed to IH treatment mimicking severe OSA condition for 14-21 days. Systolic...
Lycium barbarum polysaccharides (LBPs) are antioxidant and neuroprotective derivative from Wolfberry. However, whether LBP has a protective effect in non-alcoholic steatohepatitis (NASH)-induced hepatic injury is still unknown. We aimed to study the possible hepatoprotective effects mechanisms of on diet-induced NASH rat model. In this study, female rats were fed high-fat diet induce with or without an oral 1 mg kg−1 feeding daily for 8 weeks. After weeks, blood serum liver samples each...
One of the major problems influencing therapeutic efficacy stem cell therapy is poor survival following transplantation. This partly attributed to insufficient resistance transplanted cells oxidative and inflammatory stresses at injured sites. In current study, we demonstrated pivotal role antioxidant levels in human umbilical cord mesenchymal (hUCMSCs) dynamic vitro anti-stress abilities against lipopolysaccharide (LPS)/H2O2 intoxication vivo a murine acute liver failure model induced by...
Endothelial dysfunction plays a crucial role in the development of diabetic vasculopathy. Our initial quantitative PCR results showed an increased miR-200c expression arteries from mice and patients with diabetes. However, whether is involved endothelial unknown. Overexpression impaired endothelium-dependent relaxations (EDRs) nondiabetic mouse aortas, whereas suppression by anti–miR-200c enhanced EDRs db/db mice. suppressed ZEB1 expression, overexpression ameliorated induced or associated...