A5075786117- Cancer Genomics and Diagnostics
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Immune cells in cancer
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurological disorders and treatments
- Prenatal Screening and Diagnostics
- Cancer, Lipids, and Metabolism
- Botulinum Toxin and Related Neurological Disorders
- Drug Transport and Resistance Mechanisms
- Healthcare Policy and Management
- Cancer Mechanisms and Therapy
- Multiple Myeloma Research and Treatments
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Cytokine Signaling Pathways and Interactions
- Family Support in Illness
- Ocular Surface and Contact Lens
- Primary Care and Health Outcomes
- Renal and related cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Corneal surgery and disorders
- HIV/AIDS drug development and treatment
University of California, San Diego
2016-2024
UC San Diego Health System
2024
Chinese University of Hong Kong
2013-2023
Harvard University
2023
Prince of Wales Hospital
2020
Albany Medical Center Hospital
2016-2018
Abstract Plasma DNA fragmentomics is an emerging area of research covering plasma sizes, end points, and nucleosome footprints. In the present study, we found a significant increase in diversity motifs patients with hepatocellular carcinoma (HCC). Compared without HCC, HCC showed preferential pattern 4-mer motifs. particular, abundance motif CCCA was much lower than subjects HCC. The aberrant were also observed other cancer types, including colorectal cancer, lung nasopharyngeal carcinoma,...
Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to immune checkpoint blockade (ICB) therapy. As myeloid-derived suppressor cell (MDSC) is pivotal for immunosuppression, we investigated its role and regulation the fibrotic microenvironment with an aim of developing mechanism-based combination immunotherapy.Functional significance MDSCs was evaluated by flow cytometry using two orthotopic HCC models liver setting via carbon...
Abstract Objective Depression is common among patients diagnosed with cancer. Patients cancer and depression use more health care services compared nondepressed patients. The current study seeks to estimate the added cost of in first year after diagnosis. Methods Health charges were obtained for 2051 depressed 11 182 an International Classification Diseases, Ninth Revision, diagnosis 2014 calendar from University California San Diego Healthcare System. annual without analyzed using...
OBJECTIVE Chronic pain is a major distressing symptom of Parkinson's disease (PD) that often undertreated. Subthalamic nucleus (STN) deep brain stimulation (DBS) delivers high-frequency (HFS) to patients with PD and has been effective in relief subset these patients. However, up 74% develop new concerns while receiving STN DBS. Here the authors explore whether altering frequency DBS changes perception as measured through quantitative sensory testing (QST). METHODS Using QST, thermal...
The term "transrenal DNA" was coined in 2000 to signify that DNA urine may come from the passage of plasma through kidney barrier. Although has potential provide a completely noninvasive source nucleic acids for molecular diagnosis, its existence remains controversial.We obtained blood and samples 22 hematopoietic stem cell transplant (HSCT) recipients used fluorescence situ hybridization, PCR short tandem repeats, mass spectrometry, quantitative PCR, immunofluorescence detection study...
Hong Kong has a tripartite healthcare system, where western medicine provided in both public and private sectors coexist with Chinese practice. The purpose of this study is to measure fragmentation ambulatory care experienced by the non-institutionalized population aged 15 over such thus shed light on ongoing primary reform. This cross-sectional secondary data analysis using Thematic Household Survey, which was conducted Census Statistics Department during November 2009 February 2010 collect...
The objective of this study was to determine the rate acquired immune deficiency syndrome (AIDS) in Zhejiang province and identify specific factors associated with progression disease. This utilized a retrospective cohort involved human immunodeficiency virus (HIV) AIDS. We collected data patients existing care between 2008 2012 from national surveillance system databases. performed our analyses using multivariate Cox proportional hazards model. included 9216 HIV-positive (75.6 % male),...
Abstract Expression of ATP‐binding cassette B5 (ABCB5) has been demonstrated to confer chemoresistance, enhance cancer stem cell properties and associate with poor prognosis in hepatocellular carcinoma (HCC). The aim this study was evaluate the genetic variations ABCB5 HCC patients reference healthy individuals clinicopathological significance. A pilot examined 20 out 300 pairs paralleled blood samples using conventional sequencing method cover all exons exon/intron regions investigate...
BCAM-positive basal limbal epithelial cells are an early transit-amplifying cell population (TAC) capable of holoclone formation and corneal differentiation. Here, we present a protocol for isolating from human donor corneas by flow cytometry sorting. We describe steps dissection dissociation, antibody staining, cytometry. then detail procedures culturing the purified BCAM-negative sheet assays to study factors that regulate regeneration. For complete details on use execution this protocol,...
e19500 Background: Idecabtagene vicleucel (ide-cel) is a novel CAR T-cell therapy that targets B-cell maturation antigen (BCMA). This single-center retrospective study reports the real-world clinical outcomes of ide-cel in patients with relapsed/refractory multiple myeloma (RRMM) additional goal investigating host predictive factors for performance. Methods: We conducted review adult RRMM who received between 2021 and 2023 at University California San Diego Health had least six months...
Background/Objectives: Idecabtagene vicleucel (ide-cel), an anti-B-cell maturation chimeric antigen receptor T-cell therapy, represents unprecedented treatment option for relapsed/refractory multiple myeloma (R/R MM). Nevertheless, given its limitations, including the risk of adverse effects and unclear durability efficacy, there remains a need to report real-world clinical outcomes ide-cel therapy in patients with R/R MM, as well explore host predictive factors therapy. Methods: We...
<h3>Background</h3> Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver, exhibits relatively low responsiveness to immune-checkpoint blockade (ICB) therapy. As myeloid-derived suppressor cell (MDSC) is pivotal for immunosuppression, we investigated its role and regulation the fibrotic microenvironment with an aim of developing mechanism-based combination immunotherapy. <h3>Methods</h3> Functional significance MDSCs was evaluated by flow cytometry using two orthotopic...
April 24, 2018April 10, 2018Free AccessEvaluation of Resident Physician Exposure and Patient Access in Outpatient Continuity Clinic (P3.005)Neeraj Singh Philip YeungAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.P3.005 Letters to the Editor
Abstract Hepatocellular carcinoma (HCC) is a major global health problem and its treatment outcomes are limited by therapeutic resistance. Cancer stem cells the roots of tumor growth, recurrence, metastasis Signal transducer activator transcription 3 (STAT3) factor well known to promote carcinogenesis in number tumors. The present study aims investigate role STAT3 HCC. Total levels were examined qRT-PCR patients with primary HCC who underwent curative partial hepatectomy. Elevated...
<h3>Background</h3> Ethnic disparities in the prevalence of hepatocellular carcinoma (HCC) continue to exist. Highest age-adjusted HCC incidence rates are recorded East Asia, and 55% cases worldwide from China. Meanwhile, ABCB5 has been reported be overexpressed associated with poor survival. To evaluate ethnic differences, allele frequencies SNP rs10254317 local cohort were compared those Chinese Caucasian 1000 Genomes project, their clinical implications on patients studied....
Abstract Background/Aims: ATP-binding cassette (ABC) transporters have been shown to regulate tumor initiating cells in various cancer types and specific genotype associated with risk. ABCF1 was on priority among the ABC because gene located at 6p21, chromosome region a number of HCC risk genetic loci including HLA genes. Its family member ABCF2 also examined as their expression levels were highly correlated recurrence. Subjects Methods: A total 300 healthy blood samples (99.3% 94.7% Chinese...