A5100430260- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Parkinson's Disease Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Axon Guidance and Neuronal Signaling
- Neuropeptides and Animal Physiology
- Neuroscience and Neural Engineering
- Cancer, Stress, Anesthesia, and Immune Response
- Stress Responses and Cortisol
- Ion channel regulation and function
- Neurotransmitter Receptor Influence on Behavior
- Signaling Pathways in Disease
- Neurological Disease Mechanisms and Treatments
- Skin Protection and Aging
- Retinal Development and Disorders
- Muscle Physiology and Disorders
- RNA regulation and disease
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Epilepsy research and treatment
Unilever (China)
2021-2025
Soochow University
2024-2025
Second Affiliated Hospital of Soochow University
2025
China Medical University
2025
Taixing People's Hospital
2024
Columbia University
2006-2023
Capital Medical University
2012-2023
Tongji Hospital
2009-2023
Huazhong University of Science and Technology
2021-2023
Chinese Institute for Brain Research
2021-2023
Semaphorins, originally identified as axon guidance factors in the nervous system, play integral roles organogenesis. Here, we demonstrate a critical involvement of Sema6D cardiac morphogenesis. Ectopic expression or RNA interference against induces expansion narrowing ventricular chamber, respectively, during chick embryonic development. also exerts region-specific activities on explants, migration-promoting activity outgrowing cells from conotruncal segment, and migration-inhibitory those...
The p75 neurotrophin receptor (p75(NTR)) is associated with multiple mechanisms linked to Alzheimer's disease (AD); hence, modulating its function might confer therapeutic effects. In previous in vitro work, we developed small molecule p75(NTR) ligands that inhibited amyloid-β-induced degenerative signaling and prevented neurite degeneration. the present study, a prototype ligand, LM11A-31, was administered orally Thy-1 hAPP(Lond/Swe) (APP(L/S)) AD mouse model. LM11A-31 reached brain...
Neurotrophins and their signaling receptors, the Trk family of protein tyrosine kinases, play a major role in development mammalian nervous system. To determine precise stages that require receptor during sympathetic system, we have analyzed superior cervical ganglion (SCG) embryonic postnatal mice defective for each known receptors. Transcripts encoding TrkC are detected early development, before coalescence SCG. trk A expression appears at E13.5, becoming robust from E15.5 onward. In...
The p75 neurotrophin receptor (p75(NTR)) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75(NTR) ligands found to promote survival signaling might prevent Abeta-induced degeneration and synaptic dysfunction. These inhibited neuritic dystrophy, death of cultured pyramidal hippocampal slice cultures. Moreover, activation molecules involved AD pathology including calpain/cdk5, GSK3beta c-Jun, tau...
Abstract Faster acclimatization to high altitude upon re-ascent is seen in humans; however, the molecular basis for this enhanced adaptive response unknown. We report that healthy lowlanders, plasma adenosine levels are rapidly induced by initial ascent and achieved even higher re-ascent, a feature positively associated with quicker acclimatization. Erythrocyte equilibrative nucleoside transporter 1 (eENT1) reduced humans at mice under hypoxia. eENT1 deletion allows rapid accumulation of...
Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson's disease (PD) pathogenesis. However, molecular mechanisms which α-syn exerts neuroinflammation and neurotoxicity remain largely elusive. Targeting metabotropic glutamate receptor 5 (mGluR5) has been an attractive strategy to mediate microglia for neuroprotection, might be essential regulator modulate α-syn-induced treatment PD. Here, we showed that mGluR5 inhibited inflammation protect from...
Insufficient local levels of neurotrophic factor after spinal cord injury (SCI) are the leading cause secondary and limited axonal regeneration. Neuritin belongs to a family factors that promote neurite outgrowth, maintain neuronal survival, provide favorable microenvironment for regeneration repair nerve cells injury. However, it is not known whether exogenously applied neuritin protein has positive effect on SCI. This was investigated in present study using purified human recombinant...
Significance Deletion of genes in organisms does not always give rise to phenotypes because the existence compensation, even though may be found when gene activity is blocked acutely. The cGMP-dependent kinase II knockout a typical example this apparent paradox. shows no evident impairment LTP, whereas acute inhibition significantly decreases it. This paper describes previously unidentified form network-based compensation for that dependent on expression duplicate or paralogous genes....
Optic nerve injury (ONI) is a key cause of irreversible blindness and triggers retinal ganglion cells (RGCs) change synapse loss. Microglia the resistant immune cell in brain retina has been demonstrated to be highly related with neuron injury. However, function Sirtuin 1 (SIRT1), neuroprotective molecule, mediating microglial activation, loss subsequent death optic model as well regulatory mechanism remain unclear.To this end, crush (ONC) was conducted mimic Resveratrol EX527, specific...
Expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) can be induced by estrogens at the posttranscriptional level. However, molecular mechanism process is unclear. In this study, we found that C terminus (CT) PTEN indispensable for 17-β-estradiol (E2)-increased expression. Therefore, screened PTEN-CT-associated proteins using a glutathione-S-transferase pull-down approach in combination with mass spectrometry-based proteomic analyses. Our experiments led to...
Parkinson's disease (PD) is a common neurodegenerative characterized by substantial decrease of dopaminergic neurons in the substantia nigra pars compacta. The neurological deterioration during PD can be, part, attributed to elevated levels reactive oxygen species (ROS). Radical scavengers have previously been shown protect cells from toxic effects vitro. Hence, new approaches need be investigated improve administration antioxidants order provide neuroprotection. Polymers exhibiting catechol...
Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level lower developing PD. However, mechanistic basis for this association remains unclear. Urate protects dopaminergic neurons from cell death induced by stress. Here, we investigated novel role in microglia activation lipopolysaccharide (LPS)-induced PD model.We utilized Griess, ELISA, real-time PCR,...
The skin acts as the first line of defense against various environmental stressors, such solar ultraviolet radiation, visible light, pollution particles and ozone. Simultaneous exposure to different stressors is common in everyday life but has been less studied than single stressors. Herein, combined effects a chemical pollutant (ozone) UV radiation stressor (UVSSR) were investigated on 3D pigmented living equivalent model. Our results demonstrate that lightness (L* value) was significantly...
Background: Severe endometrial injury constitutes a significant risk to female fertility, often leading the development of intrauterine adhesions. Pyroptosis, form programmed cell death associated with inflammation, is initiated by cleavage gasdermin family proteins caspase, which has been implicated in injury. In recent years, hydrogen sulfide (H2S), gaseous signaling molecule, exerts regulatory effects on pyroptosis diverse pathological processes. The aim this study elucidate role H2S...
The epidermis acts as the body's primary defense, relying on components like lipids, HA and GSH for skin barrier function, hydration resistance to oxidative stress. However, limitations in topical application of these biomolecules call novel approaches. This study investigates efficacy Pro-GHL, a blend free fatty acids, acetylglucosamine amino acid precursors (GAPs), designed replenish through de novo biosynthesis. Using human keratinocytes, Pro-GHL demonstrated superior antioxidant...