A5078450719- Mesenchymal stem cell research
- Developmental Biology and Gene Regulation
- Chromosomal and Genetic Variations
- Autophagy in Disease and Therapy
- Congenital heart defects research
- Pancreatic function and diabetes
- RNA modifications and cancer
- Plant tissue culture and regeneration
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Diabetes and associated disorders
- Plant Taxonomy and Phylogenetics
- Plant Disease Resistance and Genetics
- Electrospun Nanofibers in Biomedical Applications
- Extracellular vesicles in disease
- Effects of Radiation Exposure
- Antimicrobial Peptides and Activities
- Pharmacological Effects of Natural Compounds
- Esophageal and GI Pathology
- Angiogenesis and VEGF in Cancer
- Protease and Inhibitor Mechanisms
- Pluripotent Stem Cells Research
Chinese PLA General Hospital
2015-2025
Second Affiliated Hospital of Chengdu University of Traditional Chinese
2022-2025
Chinese People's Liberation Army
2016-2024
Southwest Medical University
2022-2023
Institute of Vegetables and Flowers
2021-2023
Chinese Academy of Agricultural Sciences
2021-2023
Weatherford College
2022
Beijing Geriatric Hospital
2015-2016
Chinese General Hospital College of Nursing and Liberal Arts
2014
The University of Texas MD Anderson Cancer Center
1998-2009
Abstract The Brassicaceae Database (BRAD version 3.0, BRAD V3.0; http://brassicadb.cn) has evolved from the former Brassica V2.0), and represents an important community portal hosting genome information for multiple related plant species. Since last update in 2015, complex genomes of numerous species have been decoded, accompanied by many omics datasets. To provide up-to-date service, we report here a major upgrade portal. Model-View-ViewModel (MVVM) framework re-engineered to enable easy...
Despite the prevalence and recurrence of polyploidization in speciation flowering plants, its impacts on crop intraspecific genome diversification are largely unknown. Brassica rapa is a mesopolyploid species that domesticated into many subspecies with distinctive morphotypes.Herein, we report consequences whole-genome triplication (WGT) using pan-genome analysis 16 de novo assembled two reported genomes. Among genes derive from WGT, 13.42% polyploidy-derived accumulate more transposable...
Summary Brassica rapa comprises many important cultivated vegetables and oil crops. However, Chiifu v3.0, the current B. reference genome, still contains hundreds of gaps. Here, we presented a near‐complete genome assembly v4.0, which was 424.59 Mb with only two gaps, using Oxford Nanopore Technology (ONT) ultralong‐read sequencing Hi‐C technologies. The new 12 contigs, contig N50 38.26 Mb. Eight ten chromosomes were entirely reconstructed in single from telomere to telomere. We found that...
Cancer-associated mesenchymal stem cells (MSCs) play a pivotal role in modulating tumor progression. However, the interactions between liver cancer-associated MSCs (LC-MSCs) and hepatocellular carcinoma (HCC) remain unreported. Here, we identified presence of HCC tissues. We also showed that LC-MSCs significantly enhanced growth vivo promoted sphere formation vitro. metastasis an orthotopic transplantation model. Complementary DNA (cDNA) microarray analysis S100A4 expression was higher...
Abstract Background Exosomes are considered a substitute for stem cell-based therapy myocardial infarction (MI). FNDC5, transmembrane protein located in the cytoplasm, plays crucial role inflammation diseases and MI repair. Furthermore, our previous study found that FNDC5 pre-conditioning bone marrow-derived mesenchymal cells (BMMSCs) could secrete more exosomes, but little was known on Methods isolated from BMMSCs with or without FNDC5-OV were injected into infarcted hearts. Then,...
Proper development of the anterior segment mammalian eye is critical for normal ocular function. Indeed, several congenital syndromes associated with anomalies can lead to impaired vision and glaucoma. One such syndrome nail patella (NPS), caused by haploinsufficiency LIM-homeodomain transcription factor LMX1B. Although mutations in LMX1B cosegregate NPS, whether these cause glaucoma NPS not known. Here, we provide evidence that lmx1b an essential regulator murine development. Mice are...
The poor survival rate of transplanted stem cells in ischemic myocardium has limited their therapeutic efficacy. Curcumin potent antioxidant property. This study investigates whether prior curcumin treatment protects from oxidative stress injury and improves myocardial recovery following transplantation. Autologous Sprague-Dawley rat adipose derived mesenchymal (ADSCs) were pretreated with or without curcumin. hydrogen peroxide/serum deprivation (H2O2/SD) medium was used to mimic the...
Stem cell therapy has emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the poor viability of transplanted stem cells hampers their efficacy. Hypoxic preconditioning (HPC) can effectively promote survival cells. The aim this study was to investigate whether HPC improved functional bone marrow mesenchymal (BM-MSCs) and increased cardiac protective effect.BM-MSCs, isolated from Tg(Fluc-egfp) mice which constitutively express both firefly luciferase (Fluc)...
Secreted factors FGF8 and WNT1 are essential either for the inductive activity of isthmus organizer or regionalization midbrain-hindbrain boundary (MHB). However, transcriptional regulation these secreted during development remains to be elucidated. Here we show that LIM homeobox gene Lmx1b is expressed in anterior embryo as early E7.5 its expression becomes progressively restricted at E9.0. Analysis MHB mutant embryos showed many genes were lost by E9.5. In Lmx1b-/- embryos, Fgf8, which...
Radiation-induced lung injury (RILI) is a major clinical complication for radiotherapy in thoracic tumors. An immediate effect of irradiation the generation reactive oxygen that can produce oxidative damage to DNA, lipids, and proteins resulting cell or death. Currently, medical management RILI remains supportive. Therefore, there an urgent need development countermeasures. The present study aimed evaluate protective manganese superoxide dismutase (MnSOD) gene-modified mesenchymal stem cells...
Treatment with bone marrow mesenchymal stem cells (BM-MSCs) has been demonstrated to be an excellent cellular-based therapeutic strategy for treating myocardial infarction (MI). However, most of the patients suffering MI are elderly. Hypoxic conditions can cause apoptosis BM-MSCs, and this type is more prevalent in aged BM-MSCs. Decreased autophagy one mechanisms underlying aging. The aim study uncover whether increased hypoxic injury BM-MSCs due reducing diminishes tolerance hypoxia
To investigate the potential effect of IP7 on autophagy and apoptosis bone marrow mesenchymal stem cells (BM-MSCs) caused by hypoxia. BM-MSCs isolated from adult male C57BL/6 mice were exposed to normoxic condition hypoxic stress for 6 h, 12 24 respectively. Then, flow cytometry detected characteristics BM-MSCs. Furthermore, N6-(p-nitrobenzyl) purine (TNP) was administrated inhibit inositol pyrophosphates (IP7). TUNEL assay determined in with Meanwhile, RFP-GFP-LC3 plasmid transfection...
Abstract The Brassicaceae family includes many economically important crop species, as well cosmopolitan agricultural weed species. In addition, Arabidopsis thaliana, a member of this family, is used molecular model plant genus Brassica mesopolyploid, and the comprises comparatively recently originated tetrapolyploid With these characteristics, Brassicas have achieved commonly accepted status organisms for genomic studies. This paper reviews rapid research progress in from diverse omics...
Background: Stroke and vascular dementia (VaD) are major causes of death disability worldwide, there is a complex interplay between them. In this study, we applied the method Mendelian randomization (MR) network pharmacology to uncover elucidate these mechanisms. Methods: We employed single nucleotide polymorphisms that exhibit strong associations with stroke VaD as instrumental variables for MR analysis. Our bidirectional analyses were conducted using 3 robust methods: inverse variance...
ABSTRACT Background To evaluate the feasibility and safety of a novel cable‐transmitted magnetically controlled capsule endoscopy (CT‐MCE) system for upper gastrointestinal examination. Methods Twenty‐six participants (19 healthy volunteers seven patients with symptoms) willing to undergo were recruited. Each participant underwent CT‐MCE followed by conventional gastroscopy within 24 h. Maneuverability visibility in tract, adverse events, discomfort during procedure evaluated. The...
Coarse-grained (CG) molecular dynamics of proteins is a preferred approach to studying large molecules on extended time scales by condensing the entire atomic model into limited number pseudo-atoms and preserving thermodynamic properties system. However, significantly increased efficiency impedes analysis substantial physicochemical information, since high-resolution details are sacrificed accelerate simulation. In this paper, we propose LatCPB, generative based diffusion that enables...
Abstract In this single-center, double-blinded, randomized controlled trial, we investigated whether human umbilical cord-derived mesenchymal stromal cells loaded collagen scaffolds (hUC-MSC/CS) could improve the cumulative live-birth rate (cLBR) in infertile women with refractory thin endometrium (RTE). We randomly assigned 25 subfertile RTE, a 1:1 ratio, to receive hysteroscopic adhesiolysis and plowing plus either hUC-MSC/CS or saline/CS (control) for intrauterine implantation. Uterine...
Abstract The association between normal thyroid function and diabetic kidney disease (DKD) has gained increasing attention. present study evaluated the relationship hormone levels DKD in type 2 diabetes mellitus (T2DM) patients. A total of 862 patients were enrolled this cross-sectional Xi ’ an, Shaanxi Province, China. subjects for anthropometric measurements, DKD. Of patients, 246 (28.5%) suffered from DKD, prevalence did not differ men women. showed a significantly decreasing trend across...
The relationship between normal thyroid function and type 2 diabetes mellitus (T2DM) has been a particular focus for concern. present study determined the hormone levels prevalence of diabetic retinopathy (DR) in T2DM patients. A cross-sectional ( n = 633) was performed Xi’an, Shaanxi Province, China. Subjects were evaluated anthropometric measurements, function, retinopathy. Logistic regression models used to assess relationships hormones DR. Of 633 patients, 243 (38.4%) patients suffered...