A5030390345- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Colorectal and Anal Carcinomas
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cardiac Ischemia and Reperfusion
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Peptidase Inhibition and Analysis
- Sirtuins and Resveratrol in Medicine
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Air Force Medical University
2021-2025
Xijing Hospital
2024-2025
Tianjin University
2025
National Clinical Research
2014-2024
Jinzhou Medical University
2018-2024
Wuxi People's Hospital
2023-2024
Nanjing Medical University
2023-2024
Shandong University
2023-2024
Qingdao Binhai University
2024
Abstract Background Exosomes are considered a substitute for stem cell-based therapy myocardial infarction (MI). FNDC5, transmembrane protein located in the cytoplasm, plays crucial role inflammation diseases and MI repair. Furthermore, our previous study found that FNDC5 pre-conditioning bone marrow-derived mesenchymal cells (BMMSCs) could secrete more exosomes, but little was known on Methods isolated from BMMSCs with or without FNDC5-OV were injected into infarcted hearts. Then,...
Abstract Succinic acid (SA) is an important C4-dicarboxylic acid. Microbial production of SA at low pH results in purification costs and hence good overall process economics. However, redox imbalances limited biosynthesis from glucose via the reductive tricarboxylic (TCA) cycle yeast. Here, we engineer strictly aerobic yeast Yarrowia lipolytica for efficient without control. Introduction TCA into cytosol a succinate dehydrogenase-disrupted strain causes arrested cell growth. Although...
SET and MYND domain-containing protein 3 (SMYD3) plays a key role in the progression of human cancer. Matrix metalloproteinase (MMP)-9 is being related to tumor progression. It has been reported that SMYD3 MMP-9 are overexpressed cancers. However, exact roles metastasis prognosis gastric cancer (GC) remain unclear. The expressions were detected by semiquantitative reverse transcription polymerase chain reaction Western blotting adjacent nontumor tissues. In addition, analyzed...
Abstract Peritoneal metastasis is a common form of among advanced gastric cancer patients. In this study, we reported the identification LIM domain kinase 1 (LIMK1) as promoter peritoneal metastasis, and its potential to be therapeutic target dabrafenib (DAB). Using transcriptomic sequencing paired primary tumors, normal tissues, first unveiled that LIMK1 selectively up-regulated in metastatic tumors. Increased was validated by immunohistochemistry analysis an independent patient cohort....
To validate the necessity of increasing examined lymph node (ELN) count for enhancing accuracy prognostic evaluation gastric cancer (GC) patients after curative gastrectomy in multiple medical centers China.The clinicopathological data 7,620 who underwent resection GC between 2001 and 2011 were included to demonstrate whether ELN is indispensable surgery. After a meticulous stratification by using cut-point survival analysis, all allocated into three groups as: less than 16 (<16), 30...
The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs) decline with decreased cell survival, limiting their therapeutic efficacy for myocardial infarction (MI). Irisin, a novel myokine which is cleaved from its precursor fibronectin type III domain-containing protein 5 (FNDC5), believed to be involved in cardioprotective effect, but little was known on injured BM-MSCs and MI repair yet. Here, we investigated whether FNDC5 or irisin could improve the low viability...
Abstract Background Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc transcription factor superfamily, which consists of hundreds members that play critical roles in all steps tumorigenesis. Methods This study aims investigate ZSCAN18 gastric cancer (GC). The expression level GC clinicopathologic features were detected by immunohistochemistry staining. Methylation promoter tissues cell lines was analyzed via MassARRAY; same method used detect demethylated...
364 Background: RESOLVE study shows clinically meaningful improvement in perioperative SOX patients with locally advanced GC/GEJC undergoing D2 gastrectomy. Addition of PD-1 inhibitor to chemotherapy significant clinical benefit first-line treatment GC/GEJC. This trial was designed compare the sintilimab combined versus resectable Methods: PERSIST is a multicenter, prospective, open-label, randomized-controlled phase II study. Patients histologically or cytologically confirmed GC/GEJC, stage...
Abstract Background B-cell lymphoma 6 (BCL6) is a transcription repressor that plays tumor suppressor or promoting role in various tumors. However, its function and molecular mechanism gastric cancer (GC) remain unclear. Ferroptosis, novel programmed cell death, closely related to development. In this research, we aimed explore the of BCL6 malignant progression ferroptosis cancer. Methods Firstly, was identified as an important biomarker attenuated proliferation metastasis GC through...
Abstract Background Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation CpG islands in the promoter region contributes a great deal to oncogenesis and progression several cancers, including gastric cancer (GC). Protocadherin 10 ( PCDH10 ) is newly identified TSG various cancers downregulated GC; however, specific mechanisms GC remain elusive. Here, we elucidated novel epigenetic regulatory signaling pathway involving E3 ubiquitin ligase RNF180 DNA...
As the pathogenesis of cerebral small vessel disease with cognitive impairment (CSVD-CI) remains unclear, identifying effective biomarkers can contribute to clinical management CSVD-CI. This study recruited 54 healthy controls (HCs), 60 CSVD-CI patients, and 57 CSVD cognitively normal (CSVD-CN) patients. All participants underwent neuropsychological assessments multimodal magnetic resonance imaging. Macrophage migration inhibitory factors (MIFs) were assessed in plasma. The least absolute...
The contributions of aberrantly expressed metabolic enzymes to gastric cancer (GC) initiation and progression have been widely appreciated in recent years. Acetyl-CoA acetyltransferase 2 (ACAT2) is one member the acetyl- CoA thiolase family. Previous studies demonstrated that ACAT2 either promotes or suppresses tumor different conditions. However, function mechanisms GC remain unknown. We found expression this enzyme was significantly increased tissues compared with normal counterparts,...
BACKGROUND: The purpose of the present study was to provide valuable prognostic information on lymph node-negative gastric cancer patients following curative resection. METHODS: Data from 112 who underwent resection were reviewed identify independent factors overall survival and recurrence. RESULTS: five-year rate 85.7%, recurrence identified in 25 after surgery. higher than that node-positive (P<0.001). Recurrence less (P=0.001). median longer (P=0.021). Using multivariate analyses,...
It has been reported that positive surgical margin is one of the most significant risk factors for local recurrence and poor survival. However, survival gastric cancer (GC) patients with still controversial.A total 1025 stage I-III GC who underwent gastrectomy curative intent between January 2003 April 2008 in our centre were enrolled this study, whom, 75 got a microscopic resection margin. Other 950 negative used comparison.Borrmann type extranodal metastasis independent The 5-year overall...