A5101411418- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- RNA modifications and cancer
- MicroRNA in disease regulation
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Breast Cancer Treatment Studies
- Ovarian cancer diagnosis and treatment
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Multiple and Secondary Primary Cancers
- Bladder and Urothelial Cancer Treatments
- Bioactive Compounds and Antitumor Agents
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Liver physiology and pathology
Cangzhou Central Hospital
2020-2023
Third Xiangya Hospital
2021
Central South University
2021
Weifang Medical University
2019
Shengli Oilfield Central Hospital
2018
Tianjin Medical University
2010-2013
Tianjin Medical University Cancer Institute and Hospital
2012
Tianjin Medical University General Hospital
2009-2010
Ovarian and breast cancer are prevalent female malignancies with increasing occurrence incidence metastasis, significantly affecting the health life quality of women globally. Anesthetic lidocaine has presented anti-tumor activities in experimental conditions. However, effect on ovarian remains elusive. We identified important function enhancing ferroptosis repressing progression cancer. Our data showed that further repressed erastin-inhibited cell viabilities. The treatment induced...
MicroRNA-181a (miRNA-181a) is a multifaceted miRNA implicated in various cellular processes, particularly cell fate determination and invasion. It frequently expressed aberrantly human tumors shows opposing functions different types of cancers. In this study, we found that miRNA-181a overexpressed Gastric cancer (GC) tissues. Clinical pathological analyses revealed the expression correlated with tumor size, lymph node metastasis, distant TNM stage. Kaplan-Meier analysis indicated...
To explore the effect of miR-106a in breast cancer cell behavior and sensitivity to chemotherapeutic agents. Tumor tissue adjacent normal were derived from 40 patients, expression was measured by reverse transcription–qPCR. Breast cells, MDA-MB-231 MCF-7, treated with miRNA-106a mimic (MM) or inhibitor (MI) negative controls. Cell proliferation MTT assay. Clonogenicity colony-forming migration invasion ability scratch test transwell assay, respectively. Apoptosis determined flow cytometry,...
This study was aimed at investigating the effects of long noncoding RNA (lncRNA) LINC02323 in ovarian cancer and its possible mechanism.Microarray analysis QPCR were utilized to identify lncRNA expression patients with cancer. MTT assay used for cell proliferation. Western blot investigate mechanism.In cancer, up-regulated miR-1343-3p down-regulated. Over-expression promoted growth reduced LDH activity levels vitro model by suppression expression. Down-regulation increased induction TGF-β...
To study the clinical efficacy and quality of life neoadjuvant chemotherapy combined with breast-conserving surgery in treatment triple-negative breast cancer.A retrospective analysis 100 patients cancer was performed from May 2012 to April 2017. The were divided into an observation group a control according different methods, 50 cases each group. received AC-T sequential after surgery, before (neoadjuvant). operation time, postoperative immune function, tumor markers, efficacy,...
Objective: To compare the clinical safety of laparoscopic (LRN) and open radical nephrectomy (ORN) surgery for large renal tumors (>7 cm).
To study the clinical effect of Zhengyuan capsule combined with neoadjuvant chemotherapy in treatment triple-negative breast cancer (TNBC).From September 2014 to 2017, 120 TNBC patients who underwent radical mastectomy our hospital were randomly divided into control group (n = 60) and observation 60). The short-term curative effect, incidence toxicity side effects, score quality life compared. Both recurrence metastasis rates also analyzed.The significantly improved objective remission rate...
Objective To validate the 2010 Edition kidney cancer TNM staging in China.Methods Data were collected from 695 operated patients Jan.1981 to Dec.2003.These staged based on 6th and 7th system,respectively.The Kaplan-Meier method,log-rank test Cox regression models used analyze survival functions.Results Compared edition system,the number of with stage T3a,T4changed 98 88,from 29 42 new system,respectively.According system,there was significant difference comparing perirenal fat invasion only...
Abstract Background: Cervical cancer (CC) is one of the most common malignant tumors female reproductive system. The tumor immunotherapy showed remarkable effect. Associated alternative splicing (AS)-event signatures provide potential therapeutic targets and improved strategies for new drug development in CC management. Methods: Clinical information messenger RNA (mRNA) expression profiles were downloaded from Cancer Genome Atlas (TCGA) database. Hub genes extracted 7 AS-related correlation...