Breast cancer (BC) is a common malignant tumor in females. The challenge treating BC overcoming chemoresistance. Exosome-mediated transfer of miRNAs molecule-shuttle intercellular communication. Thus, we aimed to investigate whether exosomal miRNA-205 could affect chemoresistance and tumorigenesis recipient cells elucidate the underlying mechanism vivo vitro. Microarray qRT-PCR assays demonstrated that was upregulated tamoxifen resistance MCF-7/TAMR-1 (M/T) M/T cell-derived exosomes...

Breast cancer is a common malignant tumor that seriously threatens women's health. stem cell (CSC)-like population may be the main factor for breast metastasis. Therefore, targeted therapy CSCs has great potential significance. Hypoxia-inducible transcription widely expressed in tumors. Studies have shown down-regulation of hypoxia signaling pathway inhibits self-renewal and increases sensitivity cells to radiotherapy chemotherapy mediated by hypoxia-inducible factor-2α (HIF-2α). However,...

Abstract Triple‐negative breast cancer (TNBC) is a highly heterogeneous disease. The aim of this study to identify the diagnostic and poor prognostic signatures in TNBC by exploring aberrant DNA methylation gene expression. Differential expression analysis paracancer samples from Cancer Genome Atlas were performed. Gene set enrichment protein–protein interaction (PPI) network was used explore mechanisms TNBC. Methylation‐gene correlation performed, multivariate Cox receiver operating...

Background: Clinical tolerance to trastuzumab greatly affects the therapeutic effect in breast cancer (BC). Long-chain non-coding RNA (lncRNA) plays an important role development of resistance, which SNHG7 can promote epithelial mesenchymal transformation (EMT) cells into, while EMT is related resistance cells. Objective: To investigate whether lncRNA-SNHG7 enhance chemotherapy and cell viability BC by regulating miR-186. Methods: SK-BR-3 HER2+BC were induced miR-186, regulate expression...

Chronic hypoxia is a common inducer of end-stage cardiovascular disease. In cells under hypoxia, the hypoxia-inducible factor-1 (HIF-1) plays vital role in regulating downstream target genes. However, mechanism cardiomyocytes still unclear. this study, we aimed to identify novel epigenetic targets HIF-1α hypoxia. H9c2 were exposed condition, and quantitative real-time PCR analysis was performed evaluate expression miR-20b-5p. The results indicated that miR-20b-5p down-regulated low oxygen...

Objective: Nano micelles (NMs) have been widely used for various biomedical applications due to its unique physiochemical properties.This study aimed investigated the anti-tumor effect of doxorubicin (Dox)-loaded Pluronic P123 (P123) and PEG2000-DSPE mixed NMs in drug-resistant breast cancer cells.Results: The expression P-gp MDR1 gene was highly expressed MCF-7R but not MCF-7 cells.The cellular uptake P123-PEG2000-DSPE (Dox) higher than that free Dox cells.Furthermore, compared with Dox,...

Breast cancer has been the leading cause of cancer-associated mortality in women worldwide. Perturbation oncogene and tumor suppressor gene expression is generally considered as fundamental initiation progression. In present study, three datasets containing information breast adjacent normal tissues that were detected using traditional microarrays downloaded batch effects removed with R programming software. The differentially expressed genes between tissue groups closely associated...

Accurate assessment of the prognosis after colorectal cancer surgery is great significance in patients with cancer. However, there no systematic analysis factors affecting currently.To systematically analyze influence clinical data and serological histological indicators on cancer, to explore that can accurately assess cancer.A total 374 were enrolled. The data, tumor-node-metastasis (TNM) stage, Dukes stage recorded. All received examinations including carcinoembryonic antigen (CEA),...

To study the clinical efficacy and quality of life neoadjuvant chemotherapy combined with breast-conserving surgery in treatment triple-negative breast cancer.A retrospective analysis 100 patients cancer was performed from May 2012 to April 2017. The were divided into an observation group a control according different methods, 50 cases each group. received AC-T sequential after surgery, before (neoadjuvant). operation time, postoperative immune function, tumor markers, efficacy,...

Objective. To explore the influence of whole-course case management model on compliance and satisfaction breast cancer patients with standardized treatment. Methods. Eighty admitted to our hospital between April 2020 June 2021 were assigned receive either conventional nursing (routine group, n = 40) or whole-process (experimental according different methods. Outcome measures included self-rating anxiety scale (SAS) scores, depression (SDS) adverse reactions, treatment compliance,...

Objective. To explore the application of professional whole-process case management during nursing in patients with triple-negative breast cancer. Methods. This study recruited 60 cancer who were diagnosed and treated at Department Breast Surgery our hospital assessed for eligibility between June 2018 2020, we assigned them a ratio 1 : via random number table method to receive either general (control group) or plus (observation group). We analyzed evaluated hospitalization, indwelling time...

To study the clinical effect of Zhengyuan capsule combined with neoadjuvant chemotherapy in treatment triple-negative breast cancer (TNBC).From September 2014 to 2017, 120 TNBC patients who underwent radical mastectomy our hospital were randomly divided into control group (n = 60) and observation 60). The short-term curative effect, incidence toxicity side effects, score quality life compared. Both recurrence metastasis rates also analyzed.The significantly improved objective remission rate...