A5101562842- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Pregnancy and preeclampsia studies
- Colorectal and Anal Carcinomas
- Nanoplatforms for cancer theranostics
- Hippo pathway signaling and YAP/TAZ
- Uterine Myomas and Treatments
- Esophageal and GI Pathology
- Renal cell carcinoma treatment
- Lanthanide and Transition Metal Complexes
- Immune cells in cancer
- RNA modifications and cancer
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Phagocytosis and Immune Regulation
- Cancer Cells and Metastasis
Tianjin Medical University Cancer Institute and Hospital
2014-2025
BGI Research
2024
BGI Group (China)
2023-2024
National Clinical Research
2023
Tianjin Medical University
2012-2014
The contributions of aberrantly expressed metabolic enzymes to gastric cancer (GC) initiation and progression have been widely appreciated in recent years. Acetyl-CoA acetyltransferase 2 (ACAT2) is one member the acetyl- CoA thiolase family. Previous studies demonstrated that ACAT2 either promotes or suppresses tumor different conditions. However, function mechanisms GC remain unknown. We found expression this enzyme was significantly increased tissues compared with normal counterparts,...
Glycemic traits are critical indicators of maternal and fetal health during pregnancy. We performed genetic analysis for five glycemic in 14,744 Chinese pregnant women. Our genome-wide association study identified 25 locus-trait associations, including established links between gestational diabetes mellitus (GDM) the genes CDKAL1 MTNR1B. Notably, we discovered a novel fasting glucose pregnancy ESR1 gene (estrogen receptor), which was validated by an independent The ESR1-GDM link recently...
364 Background: RESOLVE study shows clinically meaningful improvement in perioperative SOX patients with locally advanced GC/GEJC undergoing D2 gastrectomy. Addition of PD-1 inhibitor to chemotherapy significant clinical benefit first-line treatment GC/GEJC. This trial was designed compare the sintilimab combined versus resectable Methods: PERSIST is a multicenter, prospective, open-label, randomized-controlled phase II study. Patients histologically or cytologically confirmed GC/GEJC, stage...
4030 Background: Perioperative therapy combined with surgery is the standard treatment for locally advanced gastric or gastro-esophageal junction (G/GEJ) cancer; however, long-term survival remains suboptimal. Immunotherapy has demonstrated antitumor activity and an acceptable safety profile in G/GEJ cancer. This study aimed to evaluate efficacy of neoadjuvant Serplulimab, a PD-1 inhibitor, combination chemotherapy previously untreated, Methods: Eligible patients resectable adenocarcinoma...
294 Background: Perioperative treatment is very important to improve long-term survival for gastric/gastroesophageal junction cancer(GC/GEJC), The RESOLVE study showed that perioperative-SOX have a clinically meaningful improvement in patients with locally advanced GC/GEJC who had D2 gastrectomy. Adding PD-1 inhibitor the chemotherapy shown significant clinical benefits first-line of GC/GEJC. This trial was designed assess feasibility and efficacy this combination perioperative resectable...
Plant homeodomain finger protein 8 (PHF8) has been reported to participate in cancer development and metastasis of various types tumors. However, little is known about the functional mechanism PHF8 gastric (GC). This study aimed explore expression pattern function, role MYC/miRNA/PHF8 axis GC. was upregulated GC tissues cells as measured using quantitative reverse transcription polymerase chain reaction western blotting. knockdown suppressed proliferation, migration, invasion cells,...
Background Circulation tumor cells (CTCs) play a crucial role in cancer spread and have strong correlation with progression. Previous works of research shown that the number CTCs can be used to predict recurrence colorectal (CRC).Methods In this study, we Cyttel method isolate detect CTCs, analyzed their carcinoembryonic antigen (CEA) carbohydrate 19-9 (CA19-9) levels.Results We found amount positive (CTC ≥2 3.2 mL peripheral blood) rate were higher blood (PB) patients stage III/IV than...
Abstract Gestational diabetes mellitus (GDM) is a common complication of pregnancy with adverse effects on both mothers and fetuses. The relationship between GDM clinical information has been largely investigated; however, the role laboratory features genetic components in are relatively understudied, especially Chinese population. In this study, we recruited 21,813 pregnant women investigated risk factors for from environmental aspects. addition to serum fasting glucose urine measured first...
e16041 Background: Chemotherapy and PD-1 inhibitor have shown significant clinical benefits in first-line treatment of GC, overall survival was still dismal. The surgical intervention with curative or life prolonging intention evaluated as feasible for stage IV GC from trials retrospective cohorts. Our previous study cytotoxic chemotherapy (S-1 & PTX) combination multi-targets anti-angiogenic TKIs illustrated increased response R0 resection rate. Given the enhanced chemo, regimens, this...
Objective: To investigate the prognostic value of preoperative inflammatory and nutritional condition detection in postoperative survival, establish a model for predicting survival patients with gastric cancer. Methods: The clinicopathological data 1123 cancer who had undergone radical gastrectomy Tianjin Medical University Cancer Institute & Hospital from January 2005 to December 2014 were retrospectively analyzed. Patients history other malignancy, gastrectomy, received treatment, died...
Splenectomy often accompanies distal pancreatectomy for pancreatic cancer. However, debates persist on splenic function loss impact. Prior studies in mice revealed splenectomy promotes cancer growth by altering CD4/Foxp3 and CD8/Foxp3 ratios. The effect other immune cells remains unclear. Clinical observations indicate induces immunosuppression, heightening recurrence metastasis risk. Here, we established an orthotopic model with observed a significant increase tumor burden. Flow cytometry...
Background: Despite the increasing use of robotic gastrectomy (RG) as an alternative to laparoscopic (LG) in treating gastric cancer, controversy remains over advantages RG compared LG and there is a paucity studies comparing two techniques regarding patient survival.
Objective To explore the clinical significance of Lauren typing in prognosis evaluation gastric cancer.Methods From June 2003 to 2007,1 275 patients with cancer were selected as study objects,who received radical gastrectomy,and got pathological diagnosis after surgery.The clinic-pathological and follow-up data them complete.According World Health Organization (WHO) typing,gastric was divided into tubular adenocarcinoma,papillary adenocarcinoma,mucinous adenocarcinoma signet ring cell...
Abstract The spleen is a vital organ in the immune system, but due to anatomical location of pancreas, splenectomy often performed conjunction with distal pancreatectomy. However, controversy remains regarding increased risk recurrence and metastasis after surgery. Previous studies have shown that promotes growth spread pancreatic cancer mice by reducing ratio CD4 Foxp3 CD8 Foxp3. Nevertheless, it unclear whether deficiency affects other cells. Clinical observations leads an...