A5065668271- Chronic Lymphocytic Leukemia Research
- Cell death mechanisms and regulation
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- Metastasis and carcinoma case studies
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- RNA regulation and disease
- Mangiferin and Mango Extracts
- HIV/AIDS drug development and treatment
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- CRISPR and Genetic Engineering
- Adipokines, Inflammation, and Metabolic Diseases
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Endoplasmic Reticulum Stress and Disease
- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
Sichuan University
2019-2025
Guangdong Provincial Center for Disease Control and Prevention
2025
Affiliated Hospital of Qingdao University
2018-2025
West China Second University Hospital of Sichuan University
2025
North Sichuan Medical University
2025
Hunan Cancer Hospital
2025
Qingdao University
2014-2025
Army Medical University
2022-2024
Guangxi Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2013-2023
Numerous stressful conditions activate kinases that phosphorylate the alpha subunit of translation initiation factor 2 (eIF2α), thus attenuating mRNA and activating a gene expression program known as integrated stress response. It has been noted associated with eIF2α phosphorylation, notably accumulation unfolded proteins in endoplasmic reticulum (ER), or ER stress, are also activation nuclear kappa B (NF-κB) phosphorylation is required for NF-κB by stress. We have used pharmacologically...
Cytotoxic chemotherapy targets elements common to all nucleated human cells, such as DNA and microtubules, yet it selectively kills tumor cells. Here we show that clinical response these drugs correlates with, may be partially governed by, the pretreatment proximity of cell mitochondria apoptotic threshold, a property called mitochondrial priming. We used BH3 profiling measure priming in cells from patients with multiple myeloma, acute myelogenous lymphoblastic leukemia, ovarian cancer. This...
Recent studies have provided conflicting data regarding the role of dyslipidemia in amyotrophic lateral sclerosis (ALS). The aim this study was to determine whether cholesterol level are an independent predictor survival ALS.Cholesterol levels were measured 427 ALS subjects from three clinical trial databases.The LDL/HDL ratio did not decrease over time, despite significant declines body mass index (BMI), forced vital capacity (FVC), and ALSFRS-R. After adjusting for BMI, FVC, age, lipid...
Abstract A subset of lung cancers expresses mutant forms epidermal growth factor receptor (EGFR) that are constitutively activated. Cancers bearing activated EGFR can be effectively targeted with inhibitors such as erlotinib. However, the death-signaling pathways engaged after inhibition poorly understood. Here, we show death uses mitochondrial, or intrinsic, pathway cell controlled by BCL-2 family proteins. inhibits induced erlotinib, but BCL-2–protected cells thus rendered BCL-2–dependent...
Neonicotinoids exposure was found to induce thyroid dysfunction. However, there lack of direct evidence between neonicotinoids and hormone (TH) disruption in population study, especially children, which limits the understanding on their health hazard. To fill this knowledge gap, we conducted a cross-sectional study children rural area South China (n = 88), analyzed urinary ten (including metabolites), serum TH, thyroxine-binding globulin (TBG), stimulating (TSH) levels. Based linear...
Abstract Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous clonal disease associated with unmet medical needs. Paralleling the pathology of other cancers, AML tumorigenesis propagation can be ascribed to dysregulated cellular processes, including apoptosis. This function others are regulated by tumor suppressor P53, which plays pivotal role in leukemogenesis. Opposing P53-mediated activities mouse double minute 2 homolog (MDM2), promotes P53 degradation. Because TP53...
Development of B-cell lymphoma 2 (BCL-2)-specific inhibitors poses unique challenges in drug design because BCL-2 homology domain 3 (BH3) shared between family members and the shallow surface their protein-protein interactions. We report herein discovery extensive preclinical investigation lisaftoclax (APG-2575).Computational modeling was used to "lead" compounds. Biochemical binding, mitochondrial BH3 profiling, cell-based viability or apoptosis assays were determine selectivity potency...
Genetic variants of interferon regulatory factor 5 (IRF-5) are associated with susceptibility to systemic lupus erythematosus (SLE). IRF-5 regulates the expression proinflammatory cytokines and type I interferons (IFNs) believed be involved in pathogenesis SLE. The aim this study was determine activation status by assessing its nuclear localization immune cells SLE patients healthy donors, identify SLE-associated triggers activation.IRF-5 subpopulations peripheral blood mononuclear from 14...
The identification of targetable vulnerabilities in the context therapeutic resistance is a key challenge cancer treatment. We detected pervasive aberrant splicing as characteristic feature chronic lymphocytic leukemia (CLL), irrespective factor mutation status, which was associated with sensitivity to spliceosome modulator, E7107. Splicing modulation affected CLL survival pathways, including members B cell lymphoma-2 (BCL2) family proteins, remodeling antiapoptotic dependencies human and...
Ganoderma lucidum polysaccharide (GLP) extracted from (Leyss. ex Fr.) Karst, a traditional Chinese medicine, is biologically active substance reported to possess anti-oxidative, anti-apoptotic, and neurological protection. However, it unknown whether GLP have any protective effect against high-fat constituents-induced epithelial cell injury. The aim of this study was investigate the protection molecular mechanism on injury induced by palmitic acid (PA) in intestinal porcine line (IPEC-J2)....