A5051723855- Vaccine Coverage and Hesitancy
- Malaria Research and Control
- Tuberculosis Research and Epidemiology
- Prion Diseases and Protein Misfolding
- Viral Infections and Outbreaks Research
- Lymphoma Diagnosis and Treatment
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Child Nutrition and Water Access
- Bauxite Residue and Utilization
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Ubiquitin and proteasome pathways
- Radiation Dose and Imaging
- Influenza Virus Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Research on Leishmaniasis Studies
- Immune responses and vaccinations
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- HIV/AIDS Research and Interventions
- Respiratory viral infections research
- Cancer, Hypoxia, and Metabolism
- Immunodeficiency and Autoimmune Disorders
London School of Hygiene & Tropical Medicine
2015-2024
University of London
2006-2024
Wellcome Trust
2006-2024
University College London
1966-2024
University of Cape Town
2007-2023
Millennium Engineering and Integration (United States)
2009-2023
AstraZeneca (United Kingdom)
2023
Commonwealth Scientific and Industrial Research Organisation
2008-2022
Australian Resources Research Centre
2013-2022
Mineral Resources
2016-2022
In the wake of recent outbreak Ebola virus disease (EVD) in several African countries, World Health Organization prioritized evaluation treatment with convalescent plasma derived from patients who have recovered disease. We evaluated safety and efficacy for EVD Guinea.
Studies of the mortality among nuclear industry workforces have been carried out, and nationally combined analyses performed, in U.S., UK Canada. This paper presents results internationally data on 95,673 workers (85.4% men) monitored for external exposure to ionizing radiation employed 6 months or longer one three countries. These were undertaken obtain a more precise direct assessment carcinogenic effects protracted low-level external, predominantly gamma, radiation. The combination from...
A community-based randomized, controlled trial of permethrin impregnated bednets was carried out in a rural area northern Ghana, between July 1993 and June 1995, to assess the impact on mortality young children an intense transmission malaria no tradition bednet use. The district around Navrongo divided into 96 geographical areas 48 randomly selected households were provided with which re-impregnated every 6 months. longitudinal demographic surveillance system used record births, deaths...
If x and y are each binomially distributed with index n parameters pl p2 respectively, then the comparison of these two binomial distributions is usually displayed as a 2 X table Fisher's exact (one-sided) test may be used to null hypothesisp1 = p2, against alternative hypothesis that > p2. The based on arguing conditionally observed number ofsuccesses, i.e., + y, see Yates (1934) Fisher (1935). distribution m fixed depends P2 only through odds ratio 0 (p1q2)/(q,p2), where qi 1-Pi rhe...
Case-control and cohort studies may be employed to assess the protective efficacy of vaccines. The appropriate measure vaccine is shown depend upon mode action vaccination. Two models are considered. In first, vaccination assumed reduce instantaneous disease-rate in total vaccinated population by a constant proportion and, second, render individuals totally immune from disease. implications these two on behaviour different measures explored. It that design case-control dependent which model...
Abstract Controlled human challenge trials of SARS-CoV-2 vaccine candidates could accelerate the testing and potential rollout efficacious vaccines. By replacing conventional phase 3 candidates, such may subtract many months from licensure process, making vaccines available more quickly. Obviously, challenging volunteers with this live virus risks inducing severe disease possibly even death. However, we argue that studies, by accelerating evaluation, reduce global burden coronavirus-related...
Respiratory syncytial virus (RSV) is a globally prevalent cause of lower respiratory infection in neonates and infants. Despite its disease burden, safe effective RSV vaccine has remained elusive. In recent years, improved understanding biology innovations immunogen design resulted the advancement multiple candidates into clinical development pipeline. Given growing number vaccines trials, rapid pace at which they are being tested, likelihood that an will reach commercial market next 5-10...