Cancer metastasis is a major cause of death among women afflicted with breast cancer (BC) and understanding the molecular processes involved focus in BC research. Circular RNAs (circRNAs) have emerged as genomic regulatory molecules carcinogenesis metastasis; however, their role unclear. We characterized novel circRNA, hsa_circ_0000515, context BC. collected 340 cancerous tissues surgically resected from patients found hsa_circ_0000515 was upregulated associated poor prognosis Silencing...

Isoliquiritigenin (ISL), a natural flavonoid derived from the root of liquorice, has been reported to possess anti-inflammatory and antioxidant activities. Previous studies have found that ISL plays crucial role in anti-fibrosis adipose tissue renal tissue; however, its effect on pulmonary fibrogenesis not demonstrated. In this study, we aimed explore roles underlying mechanisms TGF-β1-induced using human lung fibroblast-derived MRC-5 cells. Cell proliferation migration were determined by...

The contributions of aberrantly expressed metabolic enzymes to gastric cancer (GC) initiation and progression have been widely appreciated in recent years. Acetyl-CoA acetyltransferase 2 (ACAT2) is one member the acetyl- CoA thiolase family. Previous studies demonstrated that ACAT2 either promotes or suppresses tumor different conditions. However, function mechanisms GC remain unknown. We found expression this enzyme was significantly increased tissues compared with normal counterparts,...

Abstract Background Zinc finger and scan domain containing 18 (ZSCAN18) belongs to the zinc transcription factor superfamily, which consists of hundreds members that play critical roles in all steps tumorigenesis. Methods This study aims investigate ZSCAN18 gastric cancer (GC). The expression level GC clinicopathologic features were detected by immunohistochemistry staining. Methylation promoter tissues cell lines was analyzed via MassARRAY; same method used detect demethylated...

Abstract Background Downregulation of certain tumor-suppressor genes (TSGs) by aberrant methylation CpG islands in the promoter region contributes a great deal to oncogenesis and progression several cancers, including gastric cancer (GC). Protocadherin 10 ( PCDH10 ) is newly identified TSG various cancers downregulated GC; however, specific mechanisms GC remain elusive. Here, we elucidated novel epigenetic regulatory signaling pathway involving E3 ubiquitin ligase RNF180 DNA...

Abstract ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, its expression is frequently silenced due promoter hypermethylation in various human cancers. However, underlying mechanisms remain largely unknown. In this study, we investigated inhibitory effects of on gastric cancer (GC) cells. We initially examined level 135 GC adjacent normal tissue pairs, showing that was strikingly decreased malignant specimens patients low...

The SOX17 (SRY-related HMG-box) transcription factor is involved in a variety of biological processes and related to the tumorigenesis progression multiple tumors. However, clinical application for breast cancer prognosis currently limited. aim this study was investigate clinicopathologic prognostic significance expression human cancer. qPCR western blot assays were performed measure cell lines 30 matched pairs corresponding noncancerous tissues. A overexpression model used examine changes...

The aberrant expression of microRNAs (miRNAs) is involved in the initiation and progression human cancers. In our study, we found that miR-539 was down-regulated breast cancer tissues cell lines. Decreased significantly associated with lymph node metastasis patients cancer. Overexpression inhibited proliferation promoted apoptosis cells. Moreover, highly expressed suppressed epithelial-mesenchymal transition (EMT) sensitized cells to cisplatin treatment. Mechanistically, target specificity...

Whereas cysteine dioxygenase 1 (CDO1) expression is lost due to its hypermethylated promoter across a range of cancer types including gastric (GC), functions and molecular underpinnings remain largely unknown. Here we demonstrate that reduced CDO1 indicative unfavorable prognosis in patients with GC. overexpression GC cells markedly inhibits cellular proliferation vitro vivo. Mechanistically, exerts this cytostatic effect via increasing oxidative stress thus activating integrated response...

Background: Regional lymph node metastasis (LNM) is a competent and the most intensive predictor for prognostic evaluation of patients after curative surgery. This study based on databases two large medical centers in North South China. It aims to establish model extragastric LNM (ELNM) ratio (LNR) node-positive gastric cancer (GC). Methods: Clinical data 874 GC with pathologically confirmed center southern China, were included as training cohort. In addition, clinical 674 from northern...

The conditional survival rate is a dynamic estimation method that changes over time. Our research aimed to assesses the disease-specific and recurrence-free among patients who undergoing radical gastrectomy for gastric cancer after neoadjuvant chemotherapy. This study included 260 with D2 lymph node dissection preoperative 2-year (CDS2) indicates have survived x years initial treatment will survive another 2 years, calculated as follows: CDS2 = Disease-Specific Survival (DSS) (x + 2)/ (x)....

Abstract Protein lysine methyltransferase SET and MYND domain-containing 3 (SMYD3) is aberrantly expressed in various cancer settings. The mechanisms that SMYD3 activates the expression of critical pro-tumoral genes an H3K4me3-dependent manner have been well described previous reports. Besides H3K4me3, H4K20me3 another catalytic product SMYD3, however it a transcriptionally repressive hallmark. Since not clear how SMYD3-elicited program functions cancer, we used gastric (GC) as model to...

Purpose: The functions of C-type lectin domain family 4 member D (CLEC4D), one the lectin/C-type lectin-like superfamily, in immunity have been well described, but its roles cancer biology remain largely unknown. Patients and Methods: This study aims to explore role CLEC4D gastric (GC). Bioinformatics preliminarily analyzed expression cancer. Immunohistochemical staining was used detect level clinical pathological characteristics biological function cell lines verified through vitro vivo...

Objective: To investigate the expression of zinc finger transcription factors-Snail and E-cadherin in adriamycin-resistant human breast cancer MCF-7/ADM cells non-resistant MCF-7 cells.

<h3>Background</h3> Lymph node metastasis (LNM) in gastric cancer (GC) stands as the pivotal determinant of patient prognosis. This phenomenon is a multifaceted process entwined with numerous factors and genes. Notably, post-translational modifications wield significant influence orchestrating tumor onset advancement by reshaping protein structure function. Malonylation modification, recently unveiled alteration employing malonyl-CoA its substrate, has emerged critical player. study...

Secretory carrier-associated membrane protein 1 (SCAMP1) is the most universally expressed member of SCAMP family, and its ability to facilitate endocytosis was demonstrated approximately two decades ago. Nevertheless, roles in cancer biology are largely unknown, although expression significantly increased types. Herein, we examined SCAMP1 gastric (GC) tissues found that it aberrantly positively correlated with tumor size lymph node metastasis. More importantly, associated poor prognosis...

Abstract As a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal–organic frameworks (MOFs) that incorporate photosensitive as functional ligands for synergistic remains formidable challenge. Herein, the first time, phosphorus corrole‐based MOFs Cor(P)‐Hf with (3,18)‐connected gea topology are reported, which constructed by Cs ‐symmetric dicarboxylate 3‐connected...