A5100693209- Gastric Cancer Management and Outcomes
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Metastasis and carcinoma case studies
- Respiratory Support and Mechanisms
- Spine and Intervertebral Disc Pathology
- Sirtuins and Resveratrol in Medicine
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Fungal Infections and Studies
- Spinal Fractures and Fixation Techniques
- Cancer-related gene regulation
- Sugarcane Cultivation and Processing
- Colorectal Cancer Surgical Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tuberculosis Research and Epidemiology
- Mitochondrial Function and Pathology
- Antifungal resistance and susceptibility
- Thermal Regulation in Medicine
- Mycobacterium research and diagnosis
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
First Affiliated Hospital of Fujian Medical University
2022-2025
Fujian Medical University
2022-2025
Chinese Academy for Environmental Planning
2025
Jiangxi Agricultural University
2025
Tianjin Medical University General Hospital
2023-2025
Henan University of Science and Technology
2025
Shanghai University
2025
BGI Research
2025
Chifeng University
2024-2025
National Clinical Research Center for Digestive Diseases
2019-2024
Ferroptosis is an iron-dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological pathological processes. However, the regulatory mechanisms for ferroptosis sensitivity remain incompletely understood. Here, we report that homozygous deletion
The fungus Cryptococcus is a major cause of meningoencephalitis in HIV-infected as well HIV-uninfected individuals with mortalities developed countries 20% and 30%, respectively. In HIV-related disease, defects T-cell immunity are paramount, whereas there little understanding mechanisms susceptibility non-HIV related especially that occurring previously healthy adults. present description the first detailed immunological study non-HIV-infected patients including those severe central nervous...
The development and prognosis of HCC involve complex molecular mechanisms, which affect the effectiveness its treatment strategies. Tumor mutational burden (TMB) is related to efficacy immunotherapy, but prognostic role TMB-related genes in has not yet been determined clearly.In this study, we identified TMB-specific with good value build diagnostic models provide guidance for patients.Weighted gene co-expression network analysis (WGCNA) was applied identify genes. And LASSO method Cox...
Summary The arabinans of the mycobacterial cell wall are key structural and immunological polymers in context arabinogalactan (AG) lipoarabinomannan (LAM) respectively. three homologous membrane proteins EmbA, EmbB EmbC known to be involved synthesis arabinan but their biochemical functions not understood. Herein we show, that LAM, AG, ceases after inactivation embC Mycobacterium smegmatis by insertional mutagenesis. LAM is restored upon complementation with wild‐type gene. Previously have...
Abstract Background Thuja orientalis has been traditionally used to treat patients who suffer from baldness and hair loss in East Asia. The present study sought investigate the growth-promoting activity of T . hot water extract underlying mechanism action. Methods After was topically applied shaved dorsal skin telogenic C57BL/6 N mice, histomorphometric analysis employed induction follicle cycle. To determine effect on telogen anagen transition, protein expression levels β-catenin Sonic...
Intracellular nicotinamide phosphoribosyltransferase (iNAMPT) is the rate-limiting enzyme of mammalian NAD+ biosynthesis salvage pathway. Using inducible and conditional knockout (cKO) mice, we show that Nampt gene deletion in adult projection neurons leads to a progressive loss body weight, hypothermia, motor neuron (MN) degeneration, function deficits, paralysis, death. causes mitochondrial dysfunction, muscle fiber type conversion, atrophy, as well defective synaptic at neuromuscular...
Studies have demonstrated low expression of miR-145 associated with cell proliferation and migration in a wide variety tumors. Here, we studied the relation to occurrence development breast cancer. Total RNA from cancer tissue corresponding adjacent normal was extracted used detect by quantitative real-time polymerase chain reaction (qRT-PCR). We also transfected cells hsa-miR-145 mimics, inhibitor, mimics negative control (mimics NC) or inhibitor (inhibitor NC). Cell analyzed colony...
Abstract Background As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate effects ribonucleotide reductase regulatory subunit M2 (RRM2) on malignant biological behaviors and activation cGAS/STING pathway. We also explored synergistic sensitization mechanisms RRM2 radiotherapy. Methods Bioinformatic tools were used evaluate clinical significance in LUAD patients. The roles phenotype DNA damage cells...
Abstract The burdens and trends of gastric cancer are poorly understood, especially in high-prevalence countries. Based on the Global Burden Disease Study 2019, we analyzed incidence, death, possible risk factors five Asian countries, relation to year, age, sex, sociodemographic index. annual percentage change was calculated estimate age-standardized incidence rate (ASIR) death (ASDR). highest ASIR per 100,000 person-years 2019 Mongolia [44 (95% uncertainty interval (UI), 34 55)], while...
Abstract Dynamin-related protein 1 (Drp1) is a crucial regulator of mitochondrial dynamics, the overactivation which can lead to cardiovascular disease. Multiple distinct posttranscriptional modifications Drp1 have been reported, among S-nitrosylation was recently introduced. However, detailed regulatory mechanism (SNO-Drp1) in cardiac microvascular dysfunction diabetes remains elusive. The present study revealed that mitogen-activated kinase 4 (MAP4K4) consistently upregulated diabetic...
The antimicrobial mechanism of Ginkgo biloba leaf extracts (GBLE) when applied to predominant spoilage bacteria (Shewanella putrefaciens and Saprophytic staphylococcus) on refrigerated pomfret minimal inhibitory concentrations (MICs) were measured by the plate counting method. GBLE at MIC 2MIC prepared in tryptic soy broth (TSB) medium equivalent amounts sterile distilled water used place as a control group. impact growth bacteria, permeability cell membrane, wall also investigated curve...
Abstract Transcatheter arterial chemoembolization (TACE) is one of the main palliative therapies for advanced hepatocellular carcinoma (HCC), which also regarded as a promising therapeutic strategy cancer treatment. However, drug-loaded microspheres (DLMs), commonly used clinical drugs, still have problems uneven particle size and unstable efficacy. Herein, gelatin was wall material microspheres, homogenous co-loaded with adriamycin Fe 3 O 4 nanoparticles (ADM/Fe -MS) were further prepared...
The study shows SRT is an effective entry inhibitor against infection of SARS-CoV-2, which currently prevalent globally. targets the S protein SARS-CoV-2 and a panel variants.