A5008910996- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Breast Cancer Treatment Studies
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Cancer Treatment and Pharmacology
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Advanced biosensing and bioanalysis techniques
- Breast Lesions and Carcinomas
- Cancer-related Molecular Pathways
- Angiogenesis and VEGF in Cancer
Nanjing Medical University
2016-2025
Jiangsu Province Hospital
2016-2025
Dalian Medical University
2023-2025
First Affiliated Hospital of Dalian Medical University
2023-2025
University of Bristol
2025
Nanjing University of Chinese Medicine
2015-2024
Macau University of Science and Technology
2024
Huadong Hospital
2024
Fudan University
2024
Chengdu University of Traditional Chinese Medicine
2024
Adriamycin and docetaxel are two agents commonly used in treatment of breast cancer, but their efficacy is often limited by the emergence chemoresistance. Recent studies indicate that exosomes act as vehicles for exchange genetic cargo between heterogeneous populations tumor cells, engendering a transmitted drug resistance cancer development progression. However, specific contribution cancer-derived poorly understood. Here we reinforced other's report human cell line MCF-7/S could acquire...
Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one the ways which cancer cells survive hypoxia. However, possible involvement m6A modification mRNA hypoxia-induced autophagy was unexplored hepatocellular carcinoma (HCC). In this study, specific variations YTHDF1 expression were detected YTHDF1-overexpressing, -knockout, -knockdown HCC cells, organoids,...
Acquired drug resistance is a major obstacle to chemotherapy of cancers. In this study, we aim investigate the role exosomes in drug-resistance transfer between breast cancer cells and detect probable mechanism. A docetaxel-resistant variant MCF-7 cell line (MCF-7/DOC) was established then compared with drug-sensitive (MCF-7/S). Exosomes were expelled from supernatant using ultracentrifugation. Drug assessed by apoptosis assay MTT examination. Expressions P-glycoprotein (P-gp) analyzed flow...
Background and Aims The development progression of hepatocellular carcinoma (HCC) is dependent on its local microenvironment. Tumor‐associated macrophages (TAMs) are deemed a key factor for the tumor microenvironment attribute to contribute aggressiveness. However, detailed mechanism underlying pro‐metastatic effect TAMs HCC remains undefined. Approach Results present study proved that were enriched in HCC. characterized by an M2‐polarized phenotype accelerated migratory potential cells...
It has been demonstrated that there are abundant stable microRNAs (miRNAs) in plasma/serum, which can be detected and potentially disease specific. However, the lack of suitable endogenous controls for serum miRNA detection is restriction widely usage this kind biomarkers between-laboratory comparison findings. We first systematically screened control miRNAs (ECMs) by testing 10 pooling samples (using both Solexa sequencing TaqMan low density array) 50 individual quantitative reverse...
Abstract Location-associated long noncoding RNA (lncRNA) was reported to interact with target protein via a cis- regulatory process especially for the Flank10kb class lncRNA. Based on this theory, we aimed explore mechanisms of Linc00974 and KRT19 (an lncRNA beyond protein) when first confirmed aberrant expression in hepatocellular carcinoma previous study. Knockdown resulted an inhibition cell proliferation invasion activation apoptosis cycle arrest vitro , which also validated by...
Breast cancer (BCa) remains chemo-unresponsive by inevitable progression of resistance to first-line treatment with docetaxel (doc). Emerging studies indicate that exosomes act as mediators intercellular communication between heterogeneous populations tumor cells, engendering a transmitted drug for development. Such modulatory effects have been related the constant shuttle biologically active molecules including microRNAs (miRNAs). Here, we aimed investigate relevance exosome-mediated miRNA...
Background/Aims: This study aims to investigate the effect of Luteolin on breast cancer in vitro and vivo interaction between miRNAs Notch signaling after intervention, illustrates possible underlying mechanism regulation loop. Methods: Cell growth/survival assays cell cycle analyses were performed evaluate survival vitro. Scratch tests, invasion tube formation carried out analyze viability identify impact angiogenesis. Critical components pathway including proteins mRNAs detected by Western...
The aim of this study is to investigate clinical significance miR-155 expression in breast cancer.TaqMan real-time RT-PCR was performed detect cancer tissues. correlation with clinicopathological factors and prognosis patients analyzed. Then, the prognostic value analyzed by univariate multivariate analyses. Moreover, effect on phenotypes cell determined antisense technology.The relative significantly higher tissues than corresponding nontumor High correlated tumor grade, advanced stage...
Breast cancer (BCa) is one of the major deadly cancers in women. However, treatment BCa still hindered by acquired-drug resistance. It increasingly reported that exosomes take part development, metastasis, and drug resistance BCa. specific role poorly understood. In this study, we investigate whether transmit through delivering miR-222. We established an adriamycin-resistant variant Michigan Cancer Foundation-7 (MCF-7) breast cell line (MCF-7/Adr) from a drug-sensitive (MCF-7/S). Exosomes...
Abstract Circular RNAs (circRNAs) are increasingly gaining importance and attention due to their diverse potential functions value as diagnostic biomarkers (disease specific). This study aims explore the novel mechanisms by which exosome-contained circRNAs promote tumor development metastasis in TNBC. We identified increased circRNA circPSMA1 TNBC cells, exosomes, serum exosomes samples from patients. The overexpression of promoted cell proliferation, migration, both vitro vivo. Moreover, we...
While adriamycin (adr) offers improvement in survival for breast cancer (BCa) patients, unfortunately, drug resistance is almost inevitable. Mounting evidence suggests that exosomes act as a vehicle genetic cargo and constantly shuttle biologically active molecules including microRNAs (miRNAs) between heterogeneous populations of tumor cells, engendering resistance-promoting niche progression. Our recent study showed from docetaxel-resistance BCa cells could modulate chemosensitivity by...
Standard adjuvant chemotherapy for triple-negative breast cancer (TNBC) includes a taxane and an anthracycline. Concomitant capecitabine may be beneficial, but robust data to support this are lacking. The efficacy safety of the addition into TNBC treatment regimen was evaluated.This randomized, open-label, phase III trial conducted in China. Eligible female patients with early after definitive surgery were randomly assigned (1:1) either (3 cycles docetaxel followed by 3 capecitabine,...