A5100421195- FOXO transcription factor regulation
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- High Altitude and Hypoxia
- Bacterial biofilms and quorum sensing
- Myofascial pain diagnosis and treatment
- Extracellular vesicles in disease
- Microbial Metabolism and Applications
- Neuroscience of respiration and sleep
- Calcium signaling and nucleotide metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Kruppel-like factors research
- Angiogenesis and VEGF in Cancer
- Adenosine and Purinergic Signaling
- Ocular Infections and Treatments
- Bipolar Disorder and Treatment
- Antibiotic Use and Resistance
- Biosensors and Analytical Detection
- Click Chemistry and Applications
- Xenotransplantation and immune response
- Medicinal Plant Pharmacodynamics Research
- Lymphatic System and Diseases
- Heat shock proteins research
Sichuan Agricultural University
2015-2025
Hospital for Sick Children
2024
Becton Dickinson (United States)
2024
Suzhou Guangji Hospital
2021
Soochow University
2021
Toronto Public Health
2020
York University
2012-2020
First Affiliated Hospital of Jinan University
2018
Tongji University
2013-2015
Tongji Hospital
2013-2015
Abstract miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this study, we determined the expression function of miR-590-3p EOC. levels were higher high-grade carcinoma when compared low-grade or tumors low malignant potential. Interestingly, plasma significantly patients EOC than subjects benign gynecologic disorders. Transient transfection mimics stable mir-590 increased cell proliferation,...
Efflux pump system-mediated bacterial multidrug resistance is one of the main causes antibiotic failure.
Cancer metastasis is a major cause of death among women afflicted with breast cancer (BC) and understanding the molecular processes involved focus in BC research. Circular RNAs (circRNAs) have emerged as genomic regulatory molecules carcinogenesis metastasis; however, their role unclear. We characterized novel circRNA, hsa_circ_0000515, context BC. collected 340 cancerous tissues surgically resected from patients found hsa_circ_0000515 was upregulated associated poor prognosis Silencing...
To explore myoelectrical activity and muscle morphology of myofascial trigger points (MTrPs) in an injury model rats.A total 24 male SD rats were randomly divided into a control group (group A) B). A blunt striking eccentric exercise applied to the vastus medialis (VM) B for 8 weeks. Later, palpable taut band (TB), local twitch response, activities two groups examined.An average 2.5 (30/12) TBs detected VM compared with none A. The MTrPs had types abnormal potential. Their amplitudes...
Phagocytes promptly resolve ingested targets to replenish lysosomes and maintain their responsiveness. The resolution process requires that degradative hydrolases, solute transporters, proteins involved in lipid traffic are delivered made active phagolysosomes. It also involves extensive membrane remodeling. We report cation channels localize phagolysosomes were essential for resolution. Specifically, the conductance of Na + by two-pore (TPCs) presence a gradient between phagolysosome lumen...
Developing quorum-sensing (QS) based anti-infection drugs is one of the most powerful strategies to combat multidrug-resistant bacteria. Paeonol has been proven attenuate QS-controlled virulence factors P. aeruginosa by down-regulating transcription QS signal molecules. This research aimed assess anti-virulence activity and mechanism paeonol against infection in vitro vivo . In this study, was found reduce adhesion invasion P.aeruginosa macrophages resist cytotoxicity induced reduced...
Nodal is a member of the transforming growth factor-β (TGF-β) superfamily that plays critical roles during embryogenesis. Recent studies in ovarian, breast, prostate, and skin cancer cells suggest also regulates cell proliferation, apoptosis, invasion cells. However, it appears to exert both tumor-suppressing tumor-promoting effects, depending on type. To further understand role tumorigenesis, we examined effect glioblastoma spheroid formation using U87 line. Treatment with recombinant...
The superbug Pseudomonas aeruginosa is among the most formidable antibiotic-resistant pathogens. With declining options for infections, new medicines are of utmost importance to combat with P. aeruginosa. In our previous study, we demonstrated that Epigallocatechin-3-gallate (EGCG) can inhibit production quorum sensing (QS)-regulated virulence factors in vitro. Accordingly, protective effect and molecular mechanisms EGCG against aeruginosa-induced pneumonia were studied a mouse model....
Xeroderma pigmentosum group F (XPF) is an important participant in the nucleotide excision repair process. This study aimed to investigate expression of DNA gene xeroderma bladder cancer and its clinical significance.Total RNA protein were extracted from 45 untreated tissues 21 hydroxycamptothecin (HCPT)-treated specimens. Real-time PCR Western blot assay used detect mRNA levels XPF, respectively. siRNA targeting XPF was knock down T24 cells 5637 cells, sensitivity XPF-depleted HCPT...
Discrete plasmonic gold nanoparticle assemblies rapidly detect ATP in single cells and microenvironments without labelling, extraction, purification or separation.
Delayed time to antimicrobial susceptibility results can impact patients' outcomes. Our study evaluated the of turnaround (TAT) and inadequate empiric antibacterial therapy (IET) in patients with bloodstream infections (BSI) caused by
Abstract Background Patients with schizophrenia have an increased prevalence of type 2 diabetes mellitus that has shown a significant association the rs7754840 polymorphism in gene encoding cyclin‐dependent kinase 5 (CDK5) regulatory subunit‐associated protein 1‐like 1 (CDKAL1). Objective To examine whether this was involved susceptibility first‐episode drug‐naive schizophrenic patients (FDSP), and further influenced their clinical symptoms. Methods This genotyped 239 FDSP 368 healthy...
<div>Abstract<p>miRNAs play important roles in gene regulation, and their dysregulation is associated with many diseases, including epithelial ovarian cancer (EOC). In this study, we determined the expression function of miR-590-3p EOC. levels were higher high-grade carcinoma when compared low-grade or tumors low malignant potential. Interestingly, plasma significantly patients EOC than subjects benign gynecologic disorders. Transient transfection mimics stable mir-590 increased...
<p>Relationship between FOXA2 or VCAN mRNA levels and patient survival.</p>
<p>Relationship between FOXA2 and VCAN methylation status their mRNA levels in the TCGA ovarian tumour samples</p>
<p>Regulation of FOXA2 by miR-590-3p and effects on cell invasion VCAN expression.</p>
<p>Relationship between FOXA2 or VCAN mRNA levels and patient survival.</p>
<p>Relationship between FOXA2 and VCAN methylation status their mRNA levels in the TCGA ovarian tumour samples</p>