A5103101956- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Pregnancy and preeclampsia studies
- SARS-CoV-2 and COVID-19 Research
- Bacterial Genetics and Biotechnology
- Infant Development and Preterm Care
- CRISPR and Genetic Engineering
- Bacterial Identification and Susceptibility Testing
- Maternal and Perinatal Health Interventions
- Antibiotic Use and Resistance
- Evolution and Genetic Dynamics
- Congenital Heart Disease Studies
- Maternal and fetal healthcare
- Family and Patient Care in Intensive Care Units
- Colorectal Cancer Screening and Detection
- Bacteriophages and microbial interactions
- Gastrointestinal Bleeding Diagnosis and Treatment
- Infant Health and Development
- Global Public Health Policies and Epidemiology
- Healthcare Systems and Reforms
- Gut microbiota and health
- Escherichia coli research studies
- Viral Infections and Vectors
- Neutropenia and Cancer Infections
- HIV/AIDS Impact and Responses
Becton Dickinson (United States)
2021-2024
University at Albany, State University of New York
2017-2020
Indiana University School of Medicine
2020
Indiana University
2020
University School
2020
Inova Fairfax Hospital
2018
Birmingham Children's Hospital
2016
Wellcome Trust
2016
Thomas Jefferson University
2015-2016
Children's of Alabama
2015
Tests that detect the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigen in clinical specimens from upper tract can provide a rapid means coronavirus disease 2019 (COVID-19) diagnosis and help identify individuals who may be infectious should isolate to prevent SARS-CoV-2 transmission. This systematic review assesses diagnostic accuracy detection COVID-19 symptomatic asymptomatic compared quantitative reverse transcription polymerase chain reaction (RT-qPCR)...
In fall 2017, 3 solid organ transplant (SOT) recipients from a common donor developed encephalitis within 1 week of transplantation, prompting suspicion transplant-transmitted infection. Eastern equine virus (EEEV) infection was identified during testing endomyocardial tissue the heart recipient.We reviewed medical records and tested serum, whole blood, cerebrospinal fluid, for evidence EEEV by multiple assays. We investigated blood transfusion as possible source remaining components serum...
ABSTRACT In clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) immunity systems, CRISPR RNAs (crRNAs) are bound by Cas proteins, and these complexes target invading nucleic acid molecules for degradation in a process known as interference. type I CRISPR-Cas the protein complex that binds DNA is Cascade. Association of Cascade with can also lead to acquisition new elements primed adaptation. Here, we assess specificity determinants Cascade-DNA...
Type 1 fimbriae and flagella, two surface organelles critical for colonization of the urinary tract by uropathogenic Escherichia coli (UPEC), mediate opposing virulence objectives. facilitate adhesion to mucosal cells promote bacterial persistence in tract, while flagella propel bacteria through urine along mucous layers during ascension upper tract. Using a transposon screen E. CFT073 fim locked-ON (L-ON) mutant, construct that constitutively expresses type represses motility, we identified...
Real-world data are needed to establish SARS-CoV-2 rapid antigen testing (RAT) as an effective and reliable approach for screening. This study included 1,952,931 individuals who provided upper respiratory specimens during screening at CityMD urgent care locations in the New York metropolitan area from October 2020 March 2021. Positive negative results, determined by BD Veritor™ System Rapid Detection of (Veritor), were obtained all individuals, with reflex reverse transcriptase-polymerase...
ABSTRACT CRISPR-Cas systems are bacterial immune that target invading nucleic acid. The hallmark of is the CRISPR array, a genetic locus includes short sequences known as “spacers”, derived from Upon exposure to an acid molecule, bacteria/archaea with functional can add new spacers their arrays in process “adaptation”. In type I systems, which represent majority found nature, adaptation occur by two mechanisms: naïve and primed. Here, we show that, for archetypal I-E system Escherichia coli...
Delayed time to antimicrobial susceptibility results can impact patients' outcomes. Our study evaluated the of turnaround (TAT) and inadequate empiric antibacterial therapy (IET) in patients with bloodstream infections (BSI) caused by
Escherichia coli phage Eco_BIFF was isolated from several laboratory stocks of E. K-12 MG1655 derivatives. The source the contamination is unknown. a lytic that shows effective growth inhibition K-12. Here, we announce complete genome sequence Eco_BIFF, and major findings its annotation.
Abstract Real-time reverse transcription polymerase chain reaction (rRT-PCR) is the primary method used for detection and diagnosis of infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since SARS-CoV-2’s entrance into United States, numerous clinical laboratories in vitro diagnostic companies have developed rRT-PCR assays, some requiring specialized materials reagents. One such assay includes cobas® SARS-CoV-2 Qualitative Assay use on 6800/8800 (Roche...
<h3>Aim</h3> The principle aim was to explore the feasibility of a Congenital Heart Assessment Tool (CHAT) as part home monitoring programme (HMP) for parents going with their infant between first and second stage surgery complex congenital heart disease, including single ventricle systemic shunt dependent conditions. This paper also reports on how many times made urgent contact health care professionals (HCP) acceptability CHAT HMP from parents’ perspective. <h3>Background</h3> HMPs were...
ABSTRACT Tests that detect the presence of SARS-CoV-2 antigen in clinical specimens from upper respiratory tract can provide a rapid means COVID-19 disease diagnosis and help identify individuals may be infectious should isolate to prevent transmission. This systematic review assesses diagnostic accuracy detection symptomatic asymptomatic compared RT-qPCR, summarizes test sensitivity using meta-regression. In total, 83 studies were included lateral flow testing (RALFT) RT-qPCR for...
INTRODUCTION: The Hypertension in Pregnancy Task Force (2013) divided the diagnosis of superimposed preeclampsia into two categories: with and without severe features. This study compares obstetric outcomes women features based on this new diagnostic criteria. METHODS: Women singletons chronic hypertension who delivered between January 2008 July 2015 at a university hospital were identified criteria (2013). Primary outcome assessed was composite maternal morbidity, including placental...
INTRODUCTION: Severe gestational hypertension (GHTN) can eventually develop into preeclampsia (PE). We compare outcomes in women with severe GHTN versus non and PE without features (SF). METHODS: Retrospective cohort study of singleton pregnancies GHTN, or SF who delivered between 1/11/2008 7/1/2015 at Thomas Jefferson University Hospital. All patient's diagnosis were reclassified based on ACOG Hypertension Pregnancy Task Force (2013). Exclusion criteria: major fetal anomalies aneuploidy....
INTRODUCTION: It is unclear which women will progress from preeclampsia without severe features to more disease by delivery. The objective of this study was evaluate potential predictors progression preterm gestational hypertension (GHTN) or (PE) disease. METHODS: At a university hospital between January 2008 and July 2015, with singleton pregnancies GHTN PE diagnosed prior 34 0/7 weeks had demographic obstetric factors retrospectively collected determine if those influence features....
SARS-CoV-2 rapid antigen tests (RATs) are in high demand for reducing the spread of SARS-CoV-2. Reduced involvement from health care professionals (HCPs) collection and interpretation could significantly foster wide-spread implementation RATs, but data evaluating when used by lay people, is limited.To valuate agreement between BD Veritor test results self- HCP-collected specimens, visually- analyzer-interpreted results.Individuals with onset COVID-19 symptoms within five days enrollment had...
ABSTRACT Background Different rates of morbidity, mortality, transmission, and immune escape are associated with various strains the SARS-CoV-2 virus. With emergence new during seasonal outbreaks, ensuring that antigen-based immunoassays can detect infections across identified circulating viral variants is a crucial component infection control efforts. Objective To validate performance BD Veritor System for Rapid Detection Assay (BD assay) to concern (VOC) interest (VOI). Methods Using...
Abstract Background Rapid identification and antimicrobial susceptibility testing (AST) of pathogens causing bloodstream infections (BSI) is critical to providing accurate patient therapy. We conducted a multicenter evaluation inadequate empiric (IET) definitive therapy (IDT) from culture turn-around-time (TAT) in carbapenem susceptible (Carb-S) non-susceptible (Carb-NS) Enterobacterales (ENT) P. aeruginosa (PSA) blood specimens. Methods Hospitalized adults (≥ 18 yo) with facility reported...