A5058774457- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Colorectal Cancer Surgical Treatments
- Crystallization and Solubility Studies
- Plant-based Medicinal Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Knee injuries and reconstruction techniques
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Bacterial biofilms and quorum sensing
- MicroRNA in disease regulation
- Chemical and Physical Properties in Aqueous Solutions
- Microbial metabolism and enzyme function
- Nanoplatforms for cancer theranostics
- Nerve injury and regeneration
- Colorectal and Anal Carcinomas
- Gut microbiota and health
- Antibiotic Resistance in Bacteria
- Anorectal Disease Treatments and Outcomes
Renmin Hospital of Wuhan University
2015-2025
Sichuan Agricultural University
2020-2025
Wuhan University
2015-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2025
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2025
Sichuan University
2019-2025
University of Chinese Academy of Sciences
2025
Center for Excellence in Molecular Plant Sciences
2025
West China Hospital of Sichuan University
2025
Peking University First Hospital
2022-2025
Metastasis is a multistep biological process regulated by multiple signaling pathways. The integrity of the Golgi apparatus plays an important role in these Inspired mechanism and our previous finding about accumulation chondroitin sulfate hepatic stellate cells, we developed apparatus-targeting prodrug nanoparticle system synthesizing retinoic acid (RA)-conjugated (CS) (CS–RA). nanoparticles appeared to accumulate cancer cells realized RA release under acidic environment. We confirmed that...
Osteoarthritis (OA) is the most common chronic degenerative joint disease and mainly characterized by cartilage degeneration, subcartilage bone hyperplasia, osteophyte formation space stenosis. Recent studies showed that synovitis might also be an important pathological change of OA. However, molecular mechanisms in OA are still not well understood.This study was designed to identify key biomarkers immune infiltration synovial tissue osteoarthritis bioinformatics analysis.The gene expression...
Ferroptosis, a novel form of regulated cell death characterized by disrupted iron metabolism and the accumulation lipid peroxides, has exhibited enormous potential in therapy cancer particularly clear renal carcinoma (ccRCC). Luteolin (Lut), natural flavonoid widely existing various fruits vegetables, been proven to exert potent anticancer activity vitro vivo. However, previous studies on mechanism Lut have shown apoptosis but not ferroptosis. In present study, we identified that...
Biofilm-associated lung infections, particularly those caused by Staphylococcus aureus (S. aureus), pose significant clinical challenges to conventional therapies. S. Biofilm infections are refractory treatment due the presence of persister bacterial cells and barrier effect unique extracellular polymeric substances (EPS). This study describes development multifunctional micelles, HK-SL Ms, utilizing sophorolipid (SL) encapsulate Honokiol (HK). Ms potently disrupted EPS barrier, killed some...
The present study aimed to investigate changes in cellular immune function and regulatory T cells (Tregs) patients with hepatocellular carcinoma (HCC) prior following transcatheter arterial chemoembolization (TACE) their clinical significance. proportion of CD4+ CD8+ Tregs the peripheral blood between healthy volunteers HCC were detected by flow cytometry (1 day) one month TACE. level interleukin (IL)‑35 was examined ELISA. In HCC, total lymphocytes significantly lower compared that...
Osteoarthritis (OA) is a chronic joint disease characterized by cholesterol accumulation in chondrocytes, cartilage degeneration, as well extracellular matrix (ECM) destruction, and dysfunction. Curcumin, chemical that can reduce levels OA patients, also inhibit the progression of OA. However, high concentration curcumin may trigger apoptosis normal chondrocytes. Besides curcumin, probucol found effectively decrease level patients. Considering risk factor OA, it speculated combination...
Repairing articular cartilage defects is a great challenge due to the poor self-regenerative capability of cartilage. Hydrogel-based tissue engineering has been considered an effective strategy. In this study, inspired by mussel chemistry, catechol-modified chitosan (CS-C) hydrogel was prepared under catalysis horseradish peroxidase/hydrogen peroxide (HRP/H2O2) for defect repair in rat model. The rheological and swelling properties biodegradation behavior CS-C were investigated. Besides,...
Intestinal mucosal inflammation and epithelial barrier dysfunction have been implicated as pathological factors in inflammatory bowel disease (IBD). An emerging area of IBD research focuses on probiotics. The probiotic Escherichia coli Nissle 1917 (EcN) is an excellent choice for engineering therapeutic microbes. Elafin endogenous specific inhibitor neutrophil elastase (NE) proteinase 3, we previously found can effectively suppress the development colitis. Here, genetically engineered EcN to...
Panax notoginseng saponins (PNS) are active extracts obtained from the P. plant. PNS exhibit various anti‑inflammatory, anti‑oxidant and anti‑aging pharmacological properties in some cells. However, effects of on senescence apoptosis chondrocytes have not been studied to date. In present study, whether could limit tumor necrosis factor (TNF)‑α‑induced they slow down cartilage degeneration a surgery‑induced rat osteoarthritis (OA) model by regulating phosphatidyl inositol 3 kinase...
Background: The defense response is a type of self-protective the body that protects it from damage by pathogenic factors. Although these reactions make important contributions to occurrence and development tumors, role they play in osteosarcoma (OS), particularly immune microenvironment, remains unpredictable. Methods: This study included clinical information transcriptomic data 84 samples microarray 12 mesenchymal stem cell samples. We obtained 129 differentially expressed genes related...
Hypoxia/reoxygenation (H/R) may play an important role via senescence in the mechanism of osteoarthritis (OA) development. The synovial membrane is highly sensitive to H/R due its oxygen consumption feature. Excessive mechanical loads and oxidative stress caused by induce a senescence‑associated secretory phenotype (SASP), which related development OA. aim present study was investigate differences SASP manifestation tissue masses between tissues from healthy controls patients with used tumor...