A5100447501- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- Rheumatoid Arthritis Research and Therapies
- Mast cells and histamine
- Sulfur Compounds in Biology
- Immune Cell Function and Interaction
- Plant-Microbe Interactions and Immunity
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- HER2/EGFR in Cancer Research
- Legume Nitrogen Fixing Symbiosis
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Antioxidant Activity and Oxidative Stress
- interferon and immune responses
- Inflammasome and immune disorders
- Phytochemical compounds biological activities
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Bowel Disease
- Autoimmune and Inflammatory Disorders Research
- Antimicrobial Peptides and Activities
- Drug-Induced Adverse Reactions
- Nanoparticle-Based Drug Delivery
- Reproductive System and Pregnancy
Henan Agricultural University
2025
China Agricultural University
2023
Macau University of Science and Technology
2019-2023
Dalian Medical University
2022
Southern Medical University
2020-2022
Nanfang Hospital
2020-2022
West China Hospital of Sichuan University
2022
Translational Research Institute
2022
The University of Queensland
2022
Mater Research
2018-2022
Closely associated with type 2 diabetes mellitus (T2DM), hepatic steatosis and cardiac hypertrophy resulting from chronic excess intake can exacerbate insulin resistance (IR). The current study aims to investigate the pharmacological effects of hirsutine, one indole alkaloid isolated Uncaria rhynchophylla, on improving IR, elucidate underlying mechanism. T2DM IR in vivo were established by high-fat diet (HFD) feeding for 3 months C57BL/6 J mice. In vitro models induced high-glucose...
Abstract This retrospective study aims to investigate the diagnostic yields of multiple strategies next‐generation sequencing (NGS) for children with rare neurological disorders (NDs). A total 220 pediatric patients NDs who visited our hospital between Jan 2017 and Dec 2018 had undergone NGS were included. Most 5 years old or younger, number visiting decreased age. Seizures most common symptom in this cohort. The positive rates targeted panels (Panel), whole‐exome (WES), copy variation...
Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-κB) signaling pathway by deacetylating non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter for Toll-like receptor (TLR) and interleukin (IL)-1β receptor. Over-activated immune responses, induced infiltrated cells, excessively trigger NF-κB in other effector cells contribute to development rheumatoid arthritis (RA). It has also been reported that...
Chronic obstructive pulmonary disease (COPD) is an important public health challenge worldwide, and usually caused by significant exposure to noxious agents, particularly cigarette smoke. Recent studies have revealed that excessive production of neutrophil extracellular traps (NETs) in the airways associated with severity COPD patients. NETs are neutrophil-derived structures composed chromatin fibers decorated histones granule proteases including elastase (NE). However, effective prevention...
Abstract Objectives While myeloid-derived suppressor cells (MDSCs) were previously shown to promote a proinflammatory T helper (Th) 17 response in autoimmune conditions, potential impact of the MDSC-Th17 immune axis on abnormal bone destruction RA remains largely unknown. Methods We investigated correlation between frequency MDSCs or its subsets and joint patients. The reciprocal actions patient-derived Th17 studied using osteoclast (OC) differentiation resorption assays vitro, which further...
Purpose: Mesoporous silica (MSNs) have attracted considerable attention for its application in the field of drug delivery and biomedicine due to high surface area, large pore volume, low toxicity. Recently, numerous studies revealed that gut microbiota is critical relevance host health. However, toxicological MSNs were mainly based on degradation, biodistribution, excretion mammalian after oral administration now. Here this study, we explored impacts three kinds rats assess potential...
Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease that mainly erodes joints and surrounding tissues, if it not treated in time, can cause joint deformities loss of function. S-propargyl-cysteine (SPRC) an excellent endogenous hydrogen sulfide donor which relieve the symptoms RA through promotion H2S release via CSE/H2S pathway vivo. However, instant vivo could potentially limit its further clinical use. To solve this problem, study, SPRC-loaded poly(lactic acid) (PLA)...
S-propargyl-cysteine (SPRC), an excellent endogenous hydrogen sulfide (H2S) donor, could elevate H2S levels via the cystathionine γ-lyase (CSE)/H2S pathway both in vitro and vivo. However, immediate release of vivo daily administration SPRC potentially limited its clinical use.To solve fore-mentioned problem, this study, dendritic mesoporous silica nanoparticles (DMSN) was firstly prepared, a sustained delivery system consisted DMSN (SPRC@DMSN) then constructed. Their profiles, vivo, were...
Background & AimsMUC1 is abnormally expressed in colorectal cancer, including colitis-associated cancer (CAC), but its role tumorigenesis unclear. This study investigated MUC1's effects murine models of colitis and CAC elucidated mechanisms action.MethodsColitis were induced mice by exposure to dextran sodium sulfate or azoxymethane plus sulphate. Clinical parameters, immune cell infiltration, tumor development monitored throughout disease progression. Experiments knockout bone marrow...
Without an effective strategy for targeted therapy, glioblastoma is still incurable with a median survival of only 15 months. Both chronic inflammation and epigenetic reprogramming are hallmarks cancer. However, the mechanisms consequences their cooperation in remain unknown. Here, we discover that governs H3K27me3 through canonical NF-κB pathway to target EZH2. Being crucial mediator inflammation, signalling specifically directs expression redistribution but not H3K4me3, H3K9me3 H3K36me3....
Amphibian skin has proved repeatedly to be a largely untapped source of bioactive peptides and this is especially true members the Phyllomedusinae subfamily frogs native South Central America.Tryptophyllins are group mainly found in genus.In study, novel tryptophyllin (TPH) type 3 peptide, named AcT-3, been isolated structurally-characterised from secretion lyophilised extract red-eye leaf frog, Agalychnis callidryas.The peptide was identified purified by reverse-phase HPLC.MALDI-TOF mass...
Introduction The role of natural killer (NK) cells in rheumatoid arthritis remains controversial. We aimed to assess the NK pathogenesis arthritis. Materials and Methods percentage peripheral blood, spleen, lymph nodes inflamed paws from collagen-induced mice were examined through disease progression. Correlation between proportion subsets with score, histopathological changes, bone destruction evaluated. Adoptive cell transfer was performed determine effect NKp46 + on development, receptor...
Allogeneic stem cell transplantation (SCT) is the preferred therapy for majority of haematological malignancies, but its use limited by graft-versus-host disease (GVHD), primary life threatening complication associated with this procedure. Donor T cells, which are primed against host tissue antigens, critical mediators GVHD. Recently we reported that class II dependent priming donor CD4+ cells non-haematopoietic sufficient to elicit GVHD and early after SCT intestinal tract represents site...