A5103064151- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Computational Drug Discovery Methods
- Metabolomics and Mass Spectrometry Studies
- Flavonoids in Medical Research
- Phytochemical compounds biological activities
- Chemical synthesis and alkaloids
- Plant chemical constituents analysis
- Mass Spectrometry Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Biological Activities
- Adipose Tissue and Metabolism
- Antimicrobial agents and applications
- Morinda citrifolia extract uses
- Click Chemistry and Applications
- Fibroblast Growth Factor Research
- Analytical Chemistry and Chromatography
- Sulfur Compounds in Biology
- Mitochondrial Function and Pathology
- Advanced Proteomics Techniques and Applications
- Ferroptosis and cancer prognosis
- TGF-β signaling in diseases
- Antimicrobial Peptides and Activities
- Pharmacological Effects of Medicinal Plants
Guangzhou University of Chinese Medicine
2021-2025
Shanghai University of Sport
2024
China Anti-Doping Agency
2024
Affiliated Hospital of Jining Medical University
2022-2023
Jinzhou Medical University
2022
Macau University of Science and Technology
2020-2022
University of Macau
2017-2019
The exploration of therapeutic targets in neuroblastoma (NB), which needs more attempts, can benefit patients with high-risk NB. Based on metabolomic and transcriptomic data mediastinal NB tissues, we found that the content long-chain acylcarnitine (LCAC) was increased positively associated leptin expression advanced Leptin over-expression forced naïve CD4+ T cells to differentiate into Treg instead Th17 cells, benefited from cell proliferation, migration, drug resistance. Mechanically,...
Histone deacetylase 6 (HDAC6) acts as a regulator of the nuclear factor kappa-B (NF-κB) signaling pathway by deacetylating non-histone protein myeloid differentiation primary response 88 (MyD88) at lysine residues, which is an adapter for Toll-like receptor (TLR) and interleukin (IL)-1β receptor. Over-activated immune responses, induced infiltrated cells, excessively trigger NF-κB in other effector cells contribute to development rheumatoid arthritis (RA). It has also been reported that...
We aimed to investigate the potential pro-oncogenic properties of GREM1 by Pan-cancer multi-omics analysis. Accumulating evidence has highlighted that (Gremlin 1), serves as an inhibitor BMP (Bone Morphogenetic Protein) family, involve in bone related diseases, carcinogenesis, cell stemness, and differentiation. However, effect underlying mechanism on cancer biology remain largely elusive. The mRNA expression were extracted from GTEx (Genotype-Tissue Expression) TCGA (The Cancer Genome...
Abstract Four new prenylated acetophenone derivatives, including one dimer [acronyrone D ( 1 )] and three monomers [acronyrones E−G 2 – 4 )], along with seven known analogues 5 11 ) were obtained from the leaves of Acronychia pedunculata . Their structures absolute configurations established by analysis HRMS NMR data, single crystal X‐ray diffraction studies quantum chemical calculations. In addition, isolates tested for their anti‐proliferative acivity against HCT‐116, RKO SW480 cancer cell...
Toosendanin (TSN), a compound from Melia toosendan, exhibits severe hepatotoxicity, which restricts its clinical application. However, the mechanism is not clear. Our previous research found that covalent modification of TSN for proteins might be possible reason using human liver microsomes, and glycolytic enzymes, triosephosphate isomerase 1 (TPIS) α-enolase (ENOA), were responsible hepatotoxicity. In this study, we tried to prove these findings in cell animal models by integration...
Despite the massive investment in Alzheimer's disease (AD), there are still no disease-modifying treatments (DMTs) for AD. One major reason is attributed to limitation of clinical "one-size-fits-all" approach, since same AD treatment solely based on diagnosis was unlikely achieve good efficacy. In recent years, computational approaches multiomics data have provided an unprecedented opportunity drug discovery they can substantially lower costs and boost efficiency. this study, we intended...
Hepatotoxicity is a leading cause of drug withdrawal from the market; thus, assessment potential induced liver injury (DILI) in preclinical trials necessary. More and more research has shown that covalent modification reactive metabolites (RMs) for cellular proteins possible reason DILI. Unfortunately, so far no appropriate method can be employed to evaluate this kind DILI due low abundance RM-protein adducts complex biological samples. In study, we proposed mechanism-based strategy solve...
Triclosan (TCS), an antimicrobial agent widely used in personal care products and ubiquitously exists environment, has drawn increasing concern due to its potential exert multiple adverse effects, ranging from endocrine disruption carcinogenesis. However, the mechanism of these effects is still not fully elucidated. More more studies have shown that chemical reactive metabolites (RMs) covalently binding proteins a possible reason for but there lack appropriate methods predict or evaluate...
To evaluate the risk of myasthenia gravis (MG) associated with immune checkpoint inhibitors (ICI).
Covalent drugs are newly developed and proved to be successful therapies in past decades. However, the pharmacokinetics (PK) pharmacodynamic (PD) studies of covalent now ignore drug metabolite-protein modification. The low abundance modified proteins also prevents its investigation. Herein, a simple, selective, sensitive liquid chromatography-mass spectrometry (LC-MS)/MS quantitative method was established based on mechanism adducts using osimertinib as an example. Five metabolites with...
An-Gong-Niu-Huang-Wan (AGNHW) is a well-known formula for treating cerebrovascular diseases, with roles including clearing away heat, detoxification, and wake-up consciousness. In recent years, AGNHW has been commonly used the treatment of ischemic stroke, but mechanism by which relieves stroke not clearly elucidated. current study, we developed multiple systems pharmacology-based framework to identify potential antistroke ingredients in explore underlying mechanisms action (MOA) against...
Li-Zhong-Xiao-Pi granules (LZXP) are effective for treating gastric precancerous lesions (GPL) in traditional Chinese medicine. However, the active compounds of LZXP and their potential therapeutic mechanism GPL remained unclarified. The purpose this study is to investigate chemical composition targets LZXP. Based on accurate masses, ion fragments, literature data, a total 128 were identified sample using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry...
ABSTRACT Chlorphenesin carbamate is a skeletal muscle relaxant, and one of its metabolites 4‐chlorophenoxyacetic acid (4‐CPA), which included on the Prohibited List World Anti‐Doping Agency (WADA). The non‐prohibited substance, chlorphenesin carbamate, as potential source 4‐CPA, needs to be identified more strongly in doping control protocols. In this paper, metabolism human urine was studied. Ten volunteers were recruited take tablets orally, samples collected before after being tested....
Salt-processed Psoraleae Fructus is a commonly used tonic in clinical practice. However, its usage restricted due to the inherent toxicity. The covalent modification of proteins by reactive metabolites(RMs) plays role hepatotoxicity salt-processed Fructus. This study delves into protein RMs generated from psoralen/isopsoralen, primary toxic components Fructus, liquid chromatography-mass spectrometry(LC-MS), aiming elucidate mechanism underlying hepatic injury induced Biochemical methods were...
<p id=C2>Proteomics is an emerging field that has been shown to play a crucial role in unveiling the mechanisms underlying physiological and pathological processes, liquid chromatography-mass spectrometry (LC-MS) one of most important methods employed this field. However, complex biological systems, such as eukaryotes, it challenging perform comprehensive unbiased proteome analysis due high complexity samples enormous differences sample contents. For example, post-translational modifications...
Osthole (OST) is a bioactive natural coumarin derived from the plant Cnidium monnieri (L.) Cusson fruit (She Chuang Zi), which has various pharmacological and biological activities. OST contains an α,β- unsaturated lactone, electrophilic group that tends to be metabolized into reactive metabolites (RMs). Then, RMs are able covalently modify nucleophilic amino acid (AA) residues of target proteins. However, few researchers considered contribution covalent modification induced by or its...
Abstract Background: To evaluate the diagnostic value of artificial intelligence-assisted system (AIAS) for pulmonary nodules. Method: This observational study retrospectively enrolled patients with nodules clear pathological findings in Third Affiliated Hospital Jinzhou Medical University between July 2019 and May 2021. Receiver operating characteristic curve (ROC) multivariate logistic regression model were used to AIAS qualitative diagnosis Result: A total 112 this study, degree invasion...