A5100677153- Epigenetics and DNA Methylation
- Arsenic contamination and mitigation
- Sulfur Compounds in Biology
- Natural product bioactivities and synthesis
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Heavy Metal Exposure and Toxicity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Effects of Natural Compounds
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Bioinformatics and Genomic Networks
- RNA modifications and cancer
- Muscle Physiology and Disorders
- Alzheimer's disease research and treatments
- Eicosanoids and Hypertension Pharmacology
- Bone Metabolism and Diseases
- Health, Environment, Cognitive Aging
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Histone Deacetylase Inhibitors Research
- Inflammatory mediators and NSAID effects
Jinan University
2018-2025
Pudong Medical Center
2024-2025
Fudan University
2016-2025
Anhui Medical University
2014-2025
Hangzhou Normal University
2020-2025
Guangzhou Eighth People's Hospital
2024-2025
Shanghai Jiao Tong University
2024
Shanghai Sixth People's Hospital
2024
Nankai University
2018-2024
Shanghai University of Traditional Chinese Medicine
2014-2024
The histone demethylase PHF8 has been implicated in multiple pathological disorders, including X-linked mental retardation and tumorigenesis. However, it is not clear how the abundance function of are regulated. Here, we report that physically associates with deubiquitinase USP7. Specifically, demonstrated USP7 promotes deubiquitination stabilization PHF8, leading to upregulation a group genes, cyclin A2, critical for cell growth proliferation. USP7-encoding gene was also transcriptionally...
The osteoprotegerin (OPG)/receptor activator of nuclear factor-kappaB ligand (RANKL)/receptor (RANK) system is the dominant and final mediator osteoclastogenesis. Abnormalities this have been implicated in pathogenesis many skeletal diseases. Cyclooxygenase (COX)-2 prostaglandin (PG)E(2), a major eicosanoid product COX-2-catalyzed pathway, play key roles normal bone tissue remodeling. PGE(2) exerts its actions by binding activating E series (EP) receptor. Activation EP(2) EP(4) receptors...
Background An emerging body of evidence indicates that early-life arsenic (As) exposure may influence the trajectory health outcomes later in life. However, mechanisms underlying these observations are unknown. Objective The objective this study was to investigate prenatal As on global methylation cord blood DNA a mother/newborn pairs Matlab, Bangladesh. Design Maternal and were available from convenience sample 101 pairs. Measures included maternal urinary (uAs), (mbAs) (cbAs). Several...
Significance How NK cell development diverges from T/B commitment at the common lymphoid progenitor stage is poorly understood. Histone modification near critical gene loci often influences lineage determination. Ezh2 a histone methyltransferase frequently associated with repression. Here we observed that Ezh2-null hematopoietic stem and cells (HSPCs) or HSPCs treated inhibitors gave rise to increased precursors mature progeny display enhanced cytotoxicity against tumor cells. The latter...
Background Hydrogen sulfide (H2S), the third physiologically relevant gaseous molecule, is recognized increasingly as an anti-inflammatory mediator in various inflammatory conditions. Herein, we explored effects and mechanisms of sodium hydrosulfide (NaHS, a H2S donor) on tumor necrosis factor (TNF)-α-induced human umbilical vein endothelial cells (HUVEC) dysfunction. Methodology Principal Findings Application NaHS concentration-dependently suppressed TNF-α-induced mRNA proteins expressions...
Abstract Defective centrosome duplication is implicated in microcephaly and primordial dwarfism as well various ciliopathies cancers. Yet, how the biogenesis regulated remains poorly understood. Here we report that X-linked deubiquitinase USP9X physically associated with centriolar satellite protein CEP131, thereby stabilizing CEP131 through its activity. We demonstrate an integral component of required for biogenesis. Loss-of-function impairs gain-of-function promotes amplification...
Abstract Background: Exposure to arsenic (As) is associated with an increased risk of several cancers as well cardiovascular disease, and childhood neuro-developmental deficits. Arsenic compounds are weakly mutagenic, alter gene expression posttranslational histone modifications (PTHMs) in vitro. Methods: Water urinary As concentrations global levels 3 lysine 9 di-methylation acetylation (H3K9me2 H3K9ac), 27 tri-methylation (H3K27me3 H3K27ac), 18 (H3K18ac), 4 trimethylation (H3K4me3) were...
Abstract Hydrogen sulfide exists widely in mammalian tissues and plays a vital role physiological pathophysiological processes. However, striking differences with orders of magnitude were observed for the detected hydrogen concentrations biological matrices among different measurements literature, which lead to uncertainty examination relevance sulfide. Here, we developed validated liquid chromatography- mass spectrometry (LC-MS/MS) method determination various by derivative monobromobimane...
Cellular senescence has been viewed as a tumor suppression mechanism and also contributor to individual aging. Widespread shortening of 3' untranslated regions (3' UTRs) in messenger RNAs (mRNAs) by alternative polyadenylation (APA) recently discovered cancer cells. However, the role APA process cellular remains elusive. Here, we found that hundreds genes senescent cells tended use distal poly(A) (pA) sites, leading global lengthening UTRs reduced gene expression. Genes harbor longer were...
Central to the recognition, signaling, and repair of DNA double-strand breaks (DSBs) are MRE11-RAD50-NBS1 (MRN) complex mediator damage checkpoint protein 1 (MDC1), interplay which is essential for initiation amplification response (DDR). The intrinsic rule governing regulation function this molecular machinery remains be investigated. We report here that ubiquitin-specific protease USP7 was physically associated with MRN-MDC1 acted as a platform efficiently deubiquitinate stabilize MDC1,...
Molecular and traditional epidemiology studies have indicated a possible relationship between in utero environmental exposures increased risk for childhood cancers, especially acute leukemias. Chromosomal aberrations been associated with cancer adults. In order to more clearly define the association prenatal carcinogenic polycyclic aromatic hydrocarbons (PAH) chromosomal aberrations, aberration frequencies were measured subset of 60 newborns from Columbia Center Children's Environmental...
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder. Hydrogen sulfide (H2S), the third physiological gasotransmitter, well recognized as an anti-inflammatory mediator in various conditions. Herein, we explored protective effects of S-propargyl-cysteine (SPRC, also known ZYZ-802), endogenous H2S modulator, on RA and determined underlying mechanisms. In present study, SPRC concentration-dependently attenuated expression, reactive oxidase species generation, expression...