A5009831782- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- IL-33, ST2, and ILC Pathways
- Bone and Joint Diseases
- Skin Diseases and Diabetes
- Immune cells in cancer
- Immune Cell Function and Interaction
- Musculoskeletal synovial abnormalities and treatments
- Cytokine Signaling Pathways and Interactions
- Reproductive System and Pregnancy
- Osteoarthritis Treatment and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- S100 Proteins and Annexins
- Aerogels and thermal insulation
- Drug-Induced Hepatotoxicity and Protection
- TGF-β signaling in diseases
- Gas Sensing Nanomaterials and Sensors
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nanomaterials for catalytic reactions
University Medical Center Groningen
2024-2025
Shandong University of Traditional Chinese Medicine
2025
Sichuan Agricultural University
2025
Ministry of Agriculture and Rural Affairs
2025
Southern Medical University
2015-2024
Nanfang Hospital
2014-2024
Peking University People's Hospital
2023
Peking University
2023
University of Tasmania
2020
University of British Columbia
2019
Gouty arthritis (GA) is a common inflammatory disease with pain caused by the deposition of monosodium urate (MSU) crystals into joints and surrounding tissues. Resveratrol (Res), derived from grapes peanuts traditional Chinese medicine (TCM) Reynoutria japonica for GA, acts against oxidation inflammation. The present study aimed to investigate therapeutic effect mechanism Res on GA.Arthritis rat models, MSU-induced peritonitis mouse models bone marrow-derived macrophage (BMDM) were used in...
The aim of this study was to discuss the diagnostic value dual-energy computed tomography (DECT) in patients with gout during different disease phases. Two hundred twenty-one (136 and 85 other arthritic diseases) were recruited study. Arthrosis pain evaluated all by DECT scans. We calculated sensitivity specificity for diagnosis gout, including first onset period, less than 24 months more period. then investigated related risk factors urate crystals volume foot. onset, months, groups 35.71,...
Although elevated levels of neutrophil extracellular traps (NETs) have been reported in patients with rheumatoid arthritis (RA), the role NETs RA and relationship between macrophages pathogenesis requires further research. Here, we sought to determine reveal potential mechanism.
Abstract Objectives While myeloid-derived suppressor cells (MDSCs) were previously shown to promote a proinflammatory T helper (Th) 17 response in autoimmune conditions, potential impact of the MDSC-Th17 immune axis on abnormal bone destruction RA remains largely unknown. Methods We investigated correlation between frequency MDSCs or its subsets and joint patients. The reciprocal actions patient-derived Th17 studied using osteoclast (OC) differentiation resorption assays vitro, which further...
The reproductive and economic performance of male poultry depends on the testicular development semen quality. However, most previous studies duck reproduction have focused environmental impacts or developmental dynamics within a single breed, so mechanisms remain poorly understood. In this study, by taking total 240 males from 3 different lines (GF1, BGF2, MC) Tianfu Nonghua during first 24 post-hatch weeks as experimental objects, we comprehensively analyzed age-dependent variations in...
Abstract Background Phospholamban (PLN) p.Arg14del (R14del, R14Δ/+) is a pathogenic variant that can cause cardiomyopathy, characterized by abnormal sarcoplasmic reticulum (SR) clustering, ultimately leading to heart failure (HF). The exact pathophysiology unknown. We aim uncover R14Δ/+ disease mechanisms studying the (phospho-)proteome. Methods Proteomics and phosphoproteomics was performed on explanted human tissue from end-stage patients (N=6) versus other etiologies of HF (N=10). To...
The objective of the present study is to evaluate inhibitory effects taxol (PTX) on angiogenesis in a collagen-induced arthritis (CIA) mouse model. Collagen II (C II) and complete Freund's adjuvant (CFA) were used C57BL/6 (H-2b) mice generate CIA Random grouping was performed normal control group, model PTX 1.5 mg/kg 1.0 0.5 group. Arthritis index scores, tissue pathology synovium microvessel density (MVD) analysis performed. Immunohistochemistry enzyme-linked immunosorbent assay detect...
Although CD3-CD56+NKp44+ natural killer (NKp44+NK) cells have been linked to autoimmune diseases including inflammatory bowel disease, ankylosing spondylitis, and primary Sjogren syndrome, the expansion role of those in patients with rheumatoid arthritis (RA) remain less defined. Here, we investigate proportion pathogenesis NKp44+NK RA. The results show significantly expanded RA peripheral blood synovial fluid, which were correlated positively disease activity. They also highly expressed...
Background and Objective Emerging evidence shows that tooth loss is associated with cognitive impairment dementia. Vascular ( VCI ) a common consequence of ischemic stroke. This study investigated the association in patients acute Material Methods A total 161 subjects stroke were recruited. Within 1 wk after admission, fasting blood tests undertaken number teeth present was recorded. evaluated Montreal Cognitive Assessment (Mo CA ). Results The ≥ 8 exhibited significantly lower Mo values as...
We investigated the proportion of myeloid-derived suppressor cells (MDSCs) and their subsets in patients with rheumatic diseases clarified association between these patient clinical data.Patients healthy controls were recruited. The characteristics obtained. MDSCs marked fluorescently labelled antibodies then analyzed flow cytometry.The included 31 RA, 21 AS, 14 OA, 11 SLE arthritis, 13 without 9 Gout, 10 HUA, 25 controls. proportions MDSCs, M-MDSCs, G-MDSCs higher RA than (6.56±6.77% versus...
The aim of this study was to investigate the effects miR-92b-5p inhibitor and interleukin-18-binding protein (IL-18BP) on interleukin-18 (IL-18)-mediated inflammatory response after spinal cord injury (SCI).In work, microglia isolated from newborn C57/B6J mice in vitro culture. expression IL-18BP IL-18 measured by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) transfection into activated microglia. determined following treatment. In addition, model established mice. expressions...
Activated fibroblast-like synoviocytes (FLSs) play a crucial role in the pathogenesis and progression of rheumatoid arthritis (RA). It is urgent to develop new drugs that can effectively inhibit abnormal activation RA-FLS. In our study, RA-FLS cell line, MH7A, mice with collagen-induced (CIA) were used evaluate effect paclitaxel (PTX). Based on results, PTX inhibited migration dose-dependent manner significantly reduced spontaneous expression IL-6 , IL-8 RANKL mRNA TNF- α -induced...
Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in western world. Oridonin (OD), which major active ingredient traditional Chinese medicine Rabdosia rubescens , reportedly exerts anti‐inflammatory and antioxidative effects. Here, we first find that OD protects against APAP‐induced hepatotoxicity. The results hepatic tissue‐associated RNA‐seq metabolomics showed protective effects were dependent upon urea cycle regulation. And such regulation gut microbiota...
Previous studies have revealed that ankylosing spondylitis (AS), as the progenitor of axial spondyloarthritis (AxSpA), has been characterized by insidiously progressive nature sacroiliitis and spondylitis. Dual-energy computed tomography (DECT) recently used to analyse deposition monosodium urate (MSU) crystals with higher sensitivity specificity. However, it remains unclear whether existence MSU crystal detected DECT at sacroiliac joint in patients AxSpA also is associated existing...