A5100335780- Intracranial Aneurysms: Treatment and Complications
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Cerebrovascular and Carotid Artery Diseases
- Electrospun Nanofibers in Biomedical Applications
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Congenital Heart Disease Studies
- Moyamoya disease diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Fractures and Fixation Techniques
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Facial Rejuvenation and Surgery Techniques
- Cardiac Arrhythmias and Treatments
- Pelvic and Acetabular Injuries
- Craniofacial Disorders and Treatments
- Wound Healing and Treatments
- Coronary Interventions and Diagnostics
- Reconstructive Surgery and Microvascular Techniques
- Bone Tumor Diagnosis and Treatments
Hebei Medical University
2014-2025
Fujian Medical University
2021-2025
Shanghai Children's Medical Center
2021-2025
Chinese PLA General Hospital
2013-2024
Wuhan University of Technology
2021-2024
China Pharmaceutical University
2024
China Southern Power Grid (China)
2024
Chinese People's Liberation Army
2016-2023
Wuhan University
2005-2023
Renmin Hospital of Wuhan University
2022-2023
Synthetic chemotactic micro/nanomotors are envisioned to actively 'seek out' targets by following specific chemicals, but they mainly powered bioincompatible fuels and only show pseudochemotaxis (or advanced chemokinesis) due their weak self-reorientation capabilities. Here we demonstrate that synthetic ZnO-based Janus micromotors can be the alternative biocompatible fuel of CO2, further provide first example self-reorientation-induced biomimetic chemotaxis using them. The highly sensitive...
The poor survival rate of transplanted stem cells in ischemic myocardium has limited their therapeutic efficacy. Curcumin potent antioxidant property. This study investigates whether prior curcumin treatment protects from oxidative stress injury and improves myocardial recovery following transplantation. Autologous Sprague-Dawley rat adipose derived mesenchymal (ADSCs) were pretreated with or without curcumin. hydrogen peroxide/serum deprivation (H2O2/SD) medium was used to mimic the...
Myocardial infarction (MI) is a major cause of death and disability worldwide. In the last decade, mesenchymal stem cells (MSCs) based cell therapy has emerged as promising therapeutic strategy. Although great advance have been made using MSCs to treat MI, low viability transplanted severely limits efficiency therapy. Here, we show evidence that ex vivo pre-treatment with melatonin, an endogenous hormone newly found anti-oxidative activity, could improve survival function adipose tissue...
Nonoperative treatments for Stress Urinary Incontinence (SUI) represent an ideal treatment method. Mesenchymal stem cell (MSCs) is a new modality, but there lack of research in the field gynecological pelvic floor and no good method to induce internal MSC homing improve SUI. Herein, we develop injectable self-healing hydrogel derived from β-chitin which consists amino group quaternized (QC) aldehyde oxidized dextran (OD) between dynamic Schiff base linkage.it can carry bFGF SDF-1a be...
Objectives/Hypothesis The eustachian tube (ET) is an important landmark in skull base surgery, which has a close relationship with the petrous segment of internal carotid artery (ICA). goal current study was to establish detailed anatomic ET and ICA. Study Design Anatomical study. Methods Six silicon-injected adult cadaveric heads (12 sides) were dissected using lateral infratemporal fossa approach (type C) endoscopic endonasal approach. ICA exposed; their relationships demonstrated....
Abstract Background Major depressive disorder is a worldwide neuropsychiatric associated with various symptoms, but current antidepressants used in clinical practice have side effects and high failure rates. Andrographolide the main bioactive ingredient of Andrographis paniculata exhibits numerous pharmacological actions. This study aimed to evaluate antidepressant-like andrographolide male C57BL/6J mice. Methods The mice were explored forced swim test, tail suspension chronic unpredictable...
Stimuli-responsive nanoparticles (NPs), so-called "smart" NPs, possess great potentials in drug delivery. Presently, the intelligence of smart NPs is mainly based on their chemical or physical changes to stimuli, which are usually "mechanical" and fundamentally different from biological intelligence. Inspired by mitochondria (MT), a biosmart nanoparticle with microenvironment targeting self-adaptive capacity (MTSNP) was fabricated for ischemic tissue repair. The were designed as...
Abstract Background The niche of tissue development in vivo involves the growth matrix, biophysical cues and cell-cell interactions. Although natural extracellular matrixes may provide good supporting for seeding cells vitro, it is evitable to destroy during decellularization. Reconstructing bioactivities matrix-based scaffolds essential their usage repair. Results In study, a hybrid hydrogel was developed by incorporating single-wall carbon nanotubes (SWCNTs) into heart-derived matrixes....
Abstract Single‐atom catalysts (SACs), where individual metal atoms are anchored on support, hold great promise for electrocatalytic hydrogen evolution reactions (HERs). The inherent simplicity of the single‐atom center restricts opportunities further enhancement. Binuclear SACs, incorporating two different sites, can improve HER kinetics. However, underlying mechanisms at binuclear sites complex and not fully understood, hampering design new efficient catalyst structures. Here, a...
To analyze the echocardiography characteristics of pulmonary artery sling (PAS) and explore diagnostic value distance between bifurcation left right arteries valve annulus (DBP) in diagnosing PAS children. This retrospective study analyzed echocardiographic data from 27 children diagnosed with at our hospital March 2014 to December 2022. The were compared those 77 normal examined statistical differences two groups diameters arteries, main diameter, DBP, both uncorrected corrected for body...
Adipose tissue-derived stem cells (ADSCs) are a promising source of autologous that used for regeneration and repair infracted heart. However, the efficiency their transplantation is under debate. One possible reasons marginal improvement in ADSCs significant cell death rate implanted after being grafted into injured Therefore, overcoming poor survival may improve therapy. Due to limited concerning direct therapy, gene-transfer methods enhance cellular cardiomyoplasty efficacy. Heme...
Background High-density porous polyethylene (Medpor) has long been used in cranioplasty and is still one of the best materials for calvarial reconstruction. Calvarial defects can be effectively reconstructed with fewer complications by using Medpor. This article reports our study on use Medpor reconstructing defects. Methods Twenty-three patients who underwent from 1999 to 2011 were included this study. In all patients, was defect reconstruction, followed up at least 6 months. Results Most...
Abstract The poor survival of cells in ischaemic myocardium is a major obstacle for stem cell therapy. Exendin‐4 holds the potential cardioprotective effect based on its pleiotropic activity. This study investigated whether E xendin‐4 conjunction with adipose‐derived ( ADSC s) could improve and contribute to myocardial repairs after infarction. Myocardial infarction MI ) was induced by left anterior descending artery ligation adult male S prague‐ D awley rats. s carrying double‐fusion...
Omentin is a novel adipokine, which expressed in and released from omental adipose tissue. In the present study, effect of omentin on neural stem cells (NSCs) was investigated. NSCs are subtype cell nervous system, able to self‑renew generate neurons glia for repairing lesions. Mouse were isolated cultured vitro. Treatment with recombinant 3 5 days significantly increased size NSC neurospheres (P<0.01) enhanced viability normal conditions. addition, protected against decrease induced by...
Abstract Myocardial ischaemia is pathologically complicated; various changes in intracellular and extracellular microenvironments make it essential to develop a smart drug system with multiple stimulus responses adapt the complex process. Inspired by cobweb, this study designs microreticular nanosystem that adheres tissue sequentially responsive stimuli ischaemic microenvironment. The fabricated from hyaluronic acid (HA), ROS‐responsive B‐PDEA, hypoxia‐sensitive VEGF‐expressing plasmids...
Multiple intracranial aneurysms are difficult to treat. In order investigate the effect and safety of endovascular treatment for multiple aneurysms, 54 consecutive patients with 116 treated embolization were retrospectively enrolled. Angiography was performed immediately after at each follow-up. All clinical data analyzed. Of 56 (48.3%) embolized coiling alone, 19 (16.4%) stent-assisted coiling, 31 (26.7%) stenting 10 (8.6%) flow diverters plus coiling. After embolization, (27.6%) alone had...
Acute paraquat poisoning resulting from multiple organ failure usually has a high mortality rate. Liver and kidney, as the key oranges of detoxification elimination, their injuries may suppress toxin excretion enhance toxicity in other organs worsen prognosis. Therefore, we intended to explore prognostic value liver kidney function parameters, further evaluate correlation with more stable index urine-to-plasma (urine concentrations/plasma concentrations) instead considering concentrations...
The male-germ-cell Rac GTPase-activating protein gene (MgcRacGAP) was initially described as a human RhoGAP highly expressed in male germ cells at spermatocyte stage, but exhibits significant levels of expression most cell types. In somatic cells, MgcRacGAP found to both concentrate the midzone/midbody and be required for cytokinesis. As RhoGAP, has been proposed down-regulate RhoA, which is localized cleavage furrow midbody during Due embryonic lethality MgcRacGAP-null mutant mice lack an...