A5111922068- Neuroendocrine regulation and behavior
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Hypothalamic control of reproductive hormones
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Circadian rhythm and melatonin
- Nuclear Receptors and Signaling
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Digital Innovation in Industries
- Medical Imaging Techniques and Applications
- Developmental Biology and Gene Regulation
- Libraries and Information Services
- Neurogenesis and neuroplasticity mechanisms
- Cellular transport and secretion
- Digital Games and Media
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Biochemical Analysis and Sensing Techniques
- Genetic Mapping and Diversity in Plants and Animals
IU International University of Applied Sciences
2022-2025
University Medical Center Utrecht
2007-2023
Utrecht University
1987-2015
Marine Biological Laboratory
2015
National Institute of Neurological Disorders and Stroke
2001
National Institutes of Health
1997-2001
Boston University
1997
Goethe University Frankfurt
1997
National Institute of Allergy and Infectious Diseases
1997
Alfried Krupp Hospital
1974
Forkhead transcription factors of the FoxO-group are associated with cellular processes like cell cycle progression and DNA-repair. FoxO function is regulated by protein kinase B (PKB) via phosphatidylinositol 3-kinase/PKB survival pathway. Phosphorylation serine threonine residues in specific PKB phosphorylation motifs leads to exclusion FoxO-proteins from nucleus, which excludes them exerting transactivating activity. Members have three highly conserved regions containing a motif. This...
Dopaminergic neurons in the mesodiencephalon (mdDA neurons) make precise synaptic connections with targets forebrain via mesostriatal, mesolimbic, and mesoprefrontal pathways. Because of functional importance these remarkably complex ascending axon pathways their implication human disease, mechanisms underlying development are considerable interest. Despite extensive vitro studies, molecular determinants that ensure perfect formation vivo remain mostly unknown. Here, we determine embryonic...
Today, PET and SPECT tracers cannot be imaged simultaneously at high resolutions but require 2 separate imaging systems. This paper introduces a Versatile Emission Computed Tomography system (VECTor) for radionuclides that enables simultaneous submillimeter of single-photon positron-emitting radiolabeled molecules. <b>Methods:</b> γ-photons produced both by electron–positron annihilation emitters are projected onto the same detectors means novel cylindric high-energy collimator containing...
Forkhead members of the ‘O’ class (FoxO) are transcription factors crucial for regulation metabolism, cell cycle, death and survival. FoxO regulated by insulin-mediated activation PI3K (phosphoinositide 3-kinase)–PKB (protein kinase B) signalling. Activation PI3K–PKB signalling results in phosphorylation on three conserved motifs, which essential translocation from nucleus to cytosol. FoxO6, however, remains mostly nuclear due fact that its shuttling ability is dramatically impaired. FoxO1,...
The potency of various C-terminal fragments the neurohypophyseal hormone [Arg8]vasopressin [AVP-(1-9)] was determined using different avoidance behavioral test procedures in rats. Passive behavior facilitated by these peptides. [Cyt6]AVP-(5-8) and [Cyt6]AVP-(5-9) were most potent peptides tested after postlearning injection (consolidation) preretention treatment (retrieval), respectively, s.c. treatment. Comparable results found when injected into lateral brain ventricle, but this route...
Abstract Neurodevelopmental and neuropsychiatric disorders, such as autism spectrum disorders (ASD), anorexia nervosa (AN), Alzheimer’s disease (AD), schizophrenia (SZ), are heterogeneous brain with unknown etiology. Genome wide studies have revealed a variety of risk genes for these indicating biological link between genetic signaling pathways pathology. A unique gene is Contactin 4 ( Cntn4 ), an Ig cell adhesion molecule (IgCAM) gene, which has been associated several including ASD, AN,...
Mutations in DNA underlie carcinogenesis, inherited pathology, and aging are generally thought to be introduced during meiosis mitosis. Here we report that post-mitotic neurons specific frameshift mutations occur at high frequency. These were identified vasopressin transcripts magnocellular of the homozygous Brattleboro rat predominantly consist a GA deletion GAGAG motifs. Immunocytochemistry provides evidence for similar events wild-type rats. However, diseased state rat, resulting...
Animal models for neurodevelopmental disorders (NDD) generally rely on a single genetic mutation fixed background. Recent human studies however indicate that clinical diagnosis with Autism Spectrum Disorder (ASD) is almost always associated multiple fore- and background changes. The translational value of animal model would be greatly enhanced if insults could studied in more quantitative framework across backgrounds. We used the Collaborative Cross (CC), novel mouse reference population, to...
Autism spectrum disorder (ASD) refers to a large set of neurodevelopmental disorders, which have in common both repetitive behavior and abnormalities social interactions communication. Interestingly, most forms ASD strong genetic contribution. However, the molecular underpinnings this remain elusive. The SHANK3 gene (and lesser degree SHANK2) encode for postsynaptic density (PSD) proteins SHANK3/SHANK2 CONTACTIN 4 encodes neuronal glycoprotein CONTACTIN4 (CNTN4) exhibit mutated variants are...
In diesem Paper untersuchen wir die besonderen Potenziale und Herausforderungen von Advergames – digitalen Spielen mit primärer Werbefunktion. Im Fokus stehen Auswirkungen auf Spieler:innen, Anforderungen an Entwickler:innen sowie strategische Nutzung durch Werbetreibende. Neben der Analyse gestalterischer, wirtschaftlicher ethischer Aspekte diskutieren wir, wie als Format zwischen Unterhaltung, Markeninszenierung gesellschaftlicher Verantwortung positioniert sind.
We have established a differential peptide display method, based on mass spectrometric technique, to detect peptides that show semiquantitative changes in the neurointermediate lobe (NIL) of individual rats subjected salt-loading. employed matrix-assisted laser desorption/ionization spectrometry, using single-reference combination with careful scanning whole crystal rim matrix-analyte preparation, manner molecular ions present unfractionated NIL homogenate. Comparison spectra generated from...