A5101608292- Catalytic C–H Functionalization Methods
- RNA Interference and Gene Delivery
- Sulfur-Based Synthesis Techniques
- Nanoparticle-Based Drug Delivery
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Medicinal Plant Pharmacodynamics Research
- Advanced biosensing and bioanalysis techniques
- Hydrogels: synthesis, properties, applications
- Bone Tissue Engineering Materials
- Supramolecular Self-Assembly in Materials
- Cyclopropane Reaction Mechanisms
- Virus-based gene therapy research
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Oxidative Organic Chemistry Reactions
- Genomics and Phylogenetic Studies
- Bone Metabolism and Diseases
- Lichen and fungal ecology
- Advancements in Solid Oxide Fuel Cells
- Advanced Synthetic Organic Chemistry
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Plant and fungal interactions
- Plant Toxicity and Pharmacological Properties
Hangzhou First People's Hospital
2023-2025
Westlake University
2024-2025
Inner Mongolia University of Science and Technology
2025
Zhejiang University
2020-2024
Hong Kong Polytechnic University
2018-2024
Fujian Medical University
2023
East China University of Science and Technology
2023
Zhengzhou University
2022-2023
Zhejiang University of Science and Technology
2022
China Pharmaceutical University
2017-2020
Orally administrable anticancer nanomedicines are highly desirable due to their easy and repeatable administration, but not yet feasible because the current nanomedicine cannot simultaneously overcome strong mucus villi barriers thus have very low bioavailability (BA). Herein, this work presents first polymeric micelle capable of fast permeation absorption delivering paclitaxel (PTX) efficiently tumors with therapeutic efficacy even better than intravenously administered polyethylene glycol...
Ionizable cationic lipids are recognized as an essential component of lipid nanoparticles (LNPs) for messenger RNA (mRNA) delivery but can be confounded by low lipoplex stability with mRNA during storage and in vivo delivery. Herein, the rational design combinatorial synthesis esterase-triggered decationizable quaternium lipid-like molecules (lipidoids) reported to develop new LNPs high efficiency improved stability. This top lipidoid carries positive charges at physiological condition...
Abstract Cationic polymers dynamically complex DNA into complexes (polyplexes). So, upon dilution, polyplexes easily dissociate and lose transfection ability, limiting their in vivo systemic gene delivery. Herein, it is found that polyplex's stability endocytosis pathway determine its dose‐dependence. The of hydrophilic polycations have dose‐dependent integrity lysosome‐trafficking endocytosis; at low doses, most these dissociate, the remaining few are internalized trapped lysosomes,...
An efficient and convenient method of C5-selective halogenation quinoline derivatives was developed.
Hepatocellular carcinoma (HCC) is a highly malignant tumor that resistant to chemotherapy and immunotherapy. Icaritin (ICT), traditional Chinese medicine, has been reported as an immunoregulatory agent for treating advanced unresectable HCC. ICT induces mitophagy cause immunogenic cell death (ICD); however, the poor bioavailability of limits its therapeutic efficacy clinical use. Therefore, this study aimed assess effect using poly(2-(
23-Hydroxybetulinic acid (23-HBA) is a complex lupane triterpenoid, which has attracted increasing attention as an anticancer agent. However, its detailed mechanism of action remains elusive so far. To reveal mode action, series fluorescent 23-HBA derivatives conjugated with coumarin dyes were designed, synthesized, and evaluated for their antiproliferative activities. Subcellular localization uptake profile studies representative probe 26c performed in B16F10 cells, the results suggested...
The poor bioavailability of curcumin and its derivatives limits their antitumor efficacy clinical translation. Although derivative C210 has more potent activity than curcumin, it a similar deficiency to curcumin. In order improve accordingly enhance in vivo, we developed redox-responsive lipidic prodrug nano-delivery system C210. Briefly, synthesized three conjugates oleyl alcohol (OA) via different linkages containing single sulfur/disulfide/carbon bonds prepared nanoparticles using...
F-doped PrBa0.8Sr0.2Co2O5+δ-xFx (PBSCFx, x = 0, 0.025, 0.05, 0.075, 0.1) cathode powder was synthesized by the sol-gel method. X-ray diffraction results showed that all samples doped with F exhibited a typical tetragonal perovskite structure without heterophase. doping can effectively reduce thermal expansion coefficient (TEC) of materials, which decreased from 25.3699 × 10-6 K-1 PBSC to 23.5295 PBSCF0.1. The area-specific resistance (ASR) PBSCF0.05 0.0207 Ω·cm2 at 800 °C, conductivity...
Abstract Abnormal friction forces, compact matrix structure, and dynamic acidic microenvironment in osteoarthritis (OA) make it difficult to remodel cartilage regeneration by integrating prominent inflammatory responses anabolism. Here, pH‐responsive PSBMA‐ b ‐PColBP@KGN nanoparticles (PSPK NPs) are developed a simple supramolecular assembly process. PSPK NPs found reduce the coefficient of (0.028) under high loading pressure (10.41 MPa). The synergistic effect KGN release coupling deep...
Abstract A scalable catalytic synthesis method using commodity chemicals for constructing diaryl thioethers directly from sodium arylsulfinates and iodoarenes is reported in this study. In the presence of CuO or other copper salts such as Cu(OAc) 2 well palladium catalysts, DABCO demonstrated to be essential promote transformation. Various aryl sulfinates were examined viability method. The mechanistic study showed that radical reactions occurred, while N ‐oxide can observed by mass...
The TBHP/TBAI-mediated synthesis of N-(pyridine-2-yl)amides in water from ketones and 2-aminopyridine via direct oxidative C–C bond cleavage has been developed. A series ketones, including more challenging inactive aromatic substituted with diverse long-chain alkyl groups, were selectively converted to N-(pyridine-2-yl)amides. Furthermore, the protocol can be applied aryl carbinols afford corresponding amides moderate good yields.
<italic>N</italic>-(Pyridin-2-yl)amides and 3-bromoimidazo[1,2-<italic>a</italic>]pyridines were synthesized respectively from α-bromoketones 2-aminopyridine under different reaction conditions.
Hydrogen sulfide (H2S) is an important signaling molecule with promising protective effects in many physiological and pathological processes. However, the study of H2S has been impeded by lack appropriate donors that could mimic its slow-releasing process vivo. Herein, we report rational design, synthesis, biological evaluation a series thioester-based donors. These cysteine-activated release slow controllable manner. Most comprising allyl moiety showed significant cytoprotective H9c2...
A visible-light-induced oxidative carboazidation of arylacrylamides by cascade C−N and C−C bond-forming strategy is reported. Various functional groups are tolerated to afford the desired azide oxindoles in 22–86% yields under standard conditions. Mechanistic studies demonstrate that reaction proceeded via a radical pathway. As service our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be re-organized for online delivery, but...
The common pathological characteristic of osteoporosis and hypercalcemia is the disorder calcium homeostasis. Currently, salmon calcitonin (sCT), a clinical regenerative medicine, an attractive chioice to regulate metabolism for alleviation hypercalcemia. Unfortunately, serum sCT quickly cleared in vivo, leading its short half-life. Here, we designed versatile hydrogel, based on calcitonin-oxidized alginate (sCT-OCA) conjugate hydroxypropyl chitin (HPCH). release profile showed that could be...
The application of plant growth regulators (PGRs), such as abscisic acid (ABA), putrescine (Put), and 2,4-epibrassinolide (EBR), has been shown to enhance a plant's resistance various abiotic stresses. However, the protective effects these PGRs on tomato ( Solanum lycopersicum ) seedlings under suboptimal temperature stress have not yet evaluated. We also do know most effective method for cultivars. studied three rates exogenous ABA, Put, or EBR in limiting damage from two cultivars,...
Peritoneal metastasis is very common in gastrointestinal, reproductive, and genitourinary tract cancers late stages or postsurgery, causing poor prognosis, so effective nontoxic prophylactic strategies against peritoneal are highly imperative. Herein, we demonstrate the first gene transfection as a prophylaxis preventing operative metastatic dissemination. Lipopolyplexes of TNF-related-apoptosis-inducing-ligand (TRAIL) transfected peritonea macrophages to express TRAIL for over 15 days. The...
Abstract Messenger RNA (mRNA)‐based therapies have emerged as a revolutionary strategy for treating various diseases. In autoimmune diseases like rheumatoid arthritis (RA), targeted mRNA delivery provides potential intervention to modulate immune responses. However, achieving specific and efficient in vivo modulation of regulators, such the inhibitory Fc gamma receptor, FcγRIIB, on B cells remains challenging. this study, lipid polymer nanoparticles (LPNs) formulated with AMB‐POC18 lipidoid...
The first metal-free method for alkylation of quinoxalinones using cheap and stable aryl alkyl ketones as nucleophilic reagents is reported.
Abstract A visible‐light‐induced direct C( sp 2 )−H amination of quinoxalin‐2(1 H )‐ones toward the synthesis substituted 3‐aminoquinoxalin‐2(1 with TMSN 3 has been firstly developed. This transformation achieved )−H/N−H coupling in absence external ligand and oxidant. Notably, this methodology features mild reaction conditions, broad substrate scope operational simplicity. magnified image