A5073796326- Nanoplatforms for cancer theranostics
- Catalytic C–H Functionalization Methods
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Natural product bioactivities and synthesis
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Catalytic Cross-Coupling Reactions
- Plant-based Medicinal Research
- Carbohydrate Chemistry and Synthesis
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Chemical synthesis and alkaloids
- 3D Printing in Biomedical Research
- Bioactive Natural Diterpenoids Research
- Synthesis and Catalytic Reactions
- RNA Interference and Gene Delivery
- Hemoglobin structure and function
- Aquaculture Nutrition and Growth
- Cancer Immunotherapy and Biomarkers
- Biological Activity of Diterpenoids and Biflavonoids
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Synthesis and biological activity
- Asymmetric Synthesis and Catalysis
China Pharmaceutical University
2016-2025
Nanjing University
2016-2025
Xinjiang Medical University
2025
Nanjing Drum Tower Hospital
2015-2025
Nanjing General Hospital of Nanjing Military Command
2025
Harvard–MIT Division of Health Sciences and Technology
2010-2025
Massachusetts Institute of Technology
2010-2025
Brigham and Women's Hospital
2010-2025
Harvard University
2010-2025
First Affiliated Hospital of Henan University
2025
Photodynamic therapy (PDT) kills cancer cells by converting tumour oxygen into reactive singlet ((1)O2) using a photosensitizer. However, pre-existing hypoxia in tumours and consumption during PDT can result an inadequate supply, which turn hampers photodynamic efficacy. Here to overcome this problem, we create self-enriching (Oxy-PDT) loading photosensitizer perfluorocarbon nanodroplets. Because of the higher capacity longer (1)O2 lifetime perfluorocarbon, effect loaded is significantly...
Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers. Oxygen is crucial to wound healing by regulating cell proliferation, migration, and neovascularization. However, current oxygen therapies, including hyperbaric (HBO) topical gaseous (TGO), mainly employ delivery, which much less effective penetrating the skin. Here, we introduce an oxygen-producing patch, made living microalgae hydrogel, can produce dissolved oxygen. The superior performance patch...
Abstract Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. Near-infrared dye IR-780 could be used as photosensitizer both for PTT PDT, but its lipophilicity limits practical use in vivo efficiency. Herein, a simple multifunctional IR780-loaded nanoplatform based on transferrin was developed targeted imaging phototherapy cancer...
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced resistance, recent studies have described nanosystems improve oxygenation for immobilizing DNA damage simultaneously initiate oxygen-dependent HIF-1α degradation. However, degradation is incomplete during treatment alone. Therefore, combined with residual HIF-1 functional inhibition crucial optimizing therapeutic outcomes of radiotherapy. Here, a reactive oxygen...
Abstract Radiation therapy can potentially induce immunogenic cell death, thereby priming anti-tumor adaptive immune responses. However, radiation-induced systemic responses are very rare and insufficient to meet clinical needs. Here, we demonstrate a synergetic strategy for boosting death by constructing gadolinium-hemin based nanoscale coordination polymers simultaneously perform X-ray deposition glutathione depletion. Subsequently, is induced sensitized radiation potentiate checkpoint...
The detection of exogenous plant microRNAs in human/animal plasma/sera lies at the foundation exploring their cross-kingdom regulatory functions. It is necessary to establish a standard operation procedure promote study this nascent field. In study, 18 miRNAs were assessed watermelon juice and mixed fruits by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). CT values, no-template controls curves for each miRNA used evaluate specificity sensitivity qRT-PCR obtain...
Abstract Photodynamic therapy (PDT) mediated by near‐infrared (NIR) dyes is a promising cancer treatment modality; however, its use limited significant challenges, such as hypoxic tumor microenvironments and self‐quenching of photosensitizers. These challenges hamper utility in inducing immunogenic cell death (ICD) triggering potent systemic antitumor immune responses. This study demonstrates that molecular dispersion NIR nanocarriers can significantly enhance their ability to produce...
An efficient construction of fused indolines with a 2-quaternary center through palladium-catalyzed intramolecular Heck reaction N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided straightforward access to diverse good functional group tolerance.
Tumors are usually hypoxic, which limits the efficacy of current tumor therapies, especially radiotherapy in oxygen is essential to promote radiation-induced cell damage. Herein, by taking advantage ability perfluorocarbon (PFC) red blood penetration, we developed a simple but effective two-stage delivery strategy modulate hypoxic microenvironment using PFC nanoparticles. Methods: We first examined nanoparticles on relieving hypoxia through platelet inhibition. To evaluate effect radiation...
Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers' attentions. To improve the antitumor efficacy, we developed a targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used drug carrier and DNA aptamer named AS1411, had high affinity to nucleolin, bullet. The HSA nanoparticles (NPs-PTX) were fabricated by novel self-assembly method then modified with AS1411 (Apt-NPs-PTX). resulted Apt-NPs-PTX spherical....
Hypoxia-based agents (HBAs), such as anaerobic bacteria and bioreductive prodrugs, require both a permeable hypoxic intratumoural environment to be fully effective. To solve this problem, herein, we report that perfluorocarbon nanoparticles (PNPs) can used create long-lasting, penetrable tumour microenvironment for ensuring the delivery activation of subsequently administered HBAs. In addition increased permeability enhanced hypoxia caused by PNPs, PNPs retained further achieve long-term...
Spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers was synthesized in one pot without the use of metals.
Photodynamic therapy (PDT) is hampered by poor water solubility and skin phototoxicity of photosensitizers (PSs). Incorporation PSs into nanocarrier (Nano-PDT) has been designed to overcome these problems. However, self-quenching highly condensed in Nano-PDT significantly reduced singlet oxygen (1O2) generation, resulting unsatisfactory PDT efficacy. Here, we developed a novel tripleffect Nano-PDT, which special core-shell nanostructure synergistic integration perfluorotributylamine (PFTBA)...
Oxidative stress induced by hyperglycemia or chronic inflammation can limit diabetic wound healing, resulting in foot ulcers. Hydrogen has the potential to act as an antioxidant and scavenge reactive oxygen species, thereby attenuating these wounds. However, most of reported H2 delivery systems for including hydrogen gas, hydrogen-rich water, saline, are very short-lived low solubility gas. Here, we introduce a hydrogen-producing hydrogel made living Chlorella bacteria within...
The cytotoxicity of the natural ent-kaurene diterpenoid, oridonin, has been extensively studied. However, application oridonin for cancer therapy was hampered primarily by its moderate potency. In this study, a series A-ring modified analogues, and their derivatives bearing various substituents on 14-OH position, were designed, synthesized, evaluated anticancer efficacy. Some significantly more potent than against both drug-sensitive drug-resistant cells. most compound, 13p, 200-fold...