A5049162665- Renal cell carcinoma treatment
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Pediatric Urology and Nephrology Studies
- Nanocluster Synthesis and Applications
- MRI in cancer diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Renal and Vascular Pathologies
- MicroRNA in disease regulation
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Urological Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Extracellular vesicles in disease
- AI in cancer detection
- Cancer Research and Treatments
- Photodynamic Therapy Research Studies
- Urologic and reproductive health conditions
Nanjing University
2015-2025
Nanjing Drum Tower Hospital
2016-2025
Shanghai East Hospital
2025
State Key Laboratory of Cardiovascular Disease
2025
Nanjing University of Chinese Medicine
2022-2024
Ludong University
2023
Beijing Chao-Yang Hospital
2023
Capital Medical University
2023
Anhui University of Science and Technology
2023
Tsinghua University
2021
Gold nanoparticles (AuNPs) with simultaneous plasmonic and biocatalytic properties provide a promising approach to developing versatile bioassays. However, the combination of AuNPs' intrinsic enzyme-mimicking their surface-enhanced Raman scattering (SERS) activities has yet be explored. Here we designed peroxidase-mimicking nanozyme by in situ growing AuNPs into highly porous thermally stable metal–organic framework called MIL-101. The obtained AuNPs@MIL-101 nanozymes acted as peroxidase...
Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This mimics superoxide dismutase by incorporation Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable transforming radicals hydrogen peroxide. The second mimicked functionality that catalase Pt nanoparticles, which catalyze peroxide disproportionation water and oxygen. Both in vitro vivo experimental...
Photodynamic therapy (PDT) is an emerging effective treatment for cancer. However, the great promise of PDT bladder cancer has not yet been realized because tumor hypoxia. To address this challenge, we fabricated O2-generating HSA-MnO2-Ce6 NPs (HSA human serum albumin, Ce6 chlorin e6, and nanoparticles) to overcome hypoxia thus enhance photodynamic effect therapy. Methods: The were prepared. We investigated O2 generation in vitro vivo. orthotopic model C57BL/6 mice was established vivo...
Circular RNAs (circRNAs) are a novel class of endogenous noncoding formed by covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expression. CircSLC8A1 is circRNA generated from the SLC8A1 gene. Currently, role underlying molecular mechanisms circSLC8A1 bladder cancer remain unknown.The differentially expressed were identified RNA-sequencing data, was determined as new candidate circRNA. qRT-PCR used to detect expression...
Metal–organic framework (MOF) nanosheets are a class of two-dimensional (2D) porous and crystalline materials that hold promise for catalysis biodetection. Although 2D MOF have been utilized in vitro assays, ways engineering them into diagnostic tools live animals much less explored. In this work, series successfully engineered highly sensitive selective platform vivo monitoring heparin (Hep) activity. The iron-porphyrin derivative is selected as ligand to synthesize archetypical with...
Abstract The global tobacco epidemic is still a devastating threat to public health. Toxic reactive oxygen species (ROS) in the cigarette smoke cannot be efficiently eliminated by currently available filters. resultant oxidative stress causes severe lung injury and further diseases. To tackle this challenge, herein, novel copper tannic acid coordination (CuTA) nanozyme reported as highly active thermostable ROS scavenger. CuTA exhibits intrinsic superoxide dismutase‐like activity,...
Glutathione peroxidase (GPx) plays an important role in maintaining the reactive oxygen metabolic balance, yet limited GPx-mimicking nanozymes are currently available for vivo therapy. Herein, a ligand engineering strategy is developed to modulate activity of metal-organic framework (MOF) nanozyme. With different substituted ligands, activities MIL-47(V)-X (MIL stands Materials Institute Lavoisier; X=F, Br, NH2 , CH3 OH, and H) MOFs rationally regulated. best one as example, both vitro...
Abstract Antioxidant treatment strategy by scavenging reactive oxygen species (ROS) is a highly effective disease option. Nanozymes with multiple antioxidant activities can cope the diverse ROS environment. However, lack of design strategies and limitation negative correlation for nanozymes hindered their development. To overcome these difficulties, here we used ZnMn 2 O 4 as model to explore role Mn valency at octahedral site via valence‐engineered strategy, found that its are positively...
Molecular therapeutics are limited for Candida vaginitis because they damage normal cells and tissues of vagina, aggravating the imbalance vaginal microbiota increasing recurrence. To tackle this limitation, through combination peroxidase-like rGO@FeS2 nanozymes [reduced graphene oxide (rGO)] with Lactobacillus-produced lactic acid H2O2, a responsive hyaluronic (HA) hydrogel rGO@FeS2/Lactobacillus@HA (FeLab) is developed. FeLab has simultaneous anti-Candida albicans microbiota-modulating...
High tumor recurrence is frequently observed in patients with urinary bladder cancers (UBCs), the need for biomarkers of prognosis and drug response.Chemoresistance subsequent are driven by a subpopulation initiating cells, namely cancer stem-like cells (CSCs).However, underlying molecular mechanism chemotherapy-induced CSCs enrichment remains largely unclear.In this study, we found that during gemcitabine treatment lncRNA-Low Expression Tumor (lncRNA-LET) was downregulated chemoresistant...
Abstract The programmed death ligand 1 (PDL1)/programmed (PD1) costimulatory pathway plays an important role in the inhibition of alloimmune responses as well induction and maintenance peripheral tolerance. It has been demonstrated recently that PDL1 also can bind B7.1 to inhibit T cell vitro. Using bm12 into B6 heart transplant model, we investigated functional significance this interaction vivo. PD1 blockade unlike failed accelerate allograft rejection, suggesting a for additional binding...
Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative natural enzymes and conventional artificial enzymes.Among the nanozymes developed, particular interests been devoted peroxidase mimicking activities because of promising applications in biosensing, bioimaging, biomedicine, etc. Till now, lots functional used mimic peroxidase.However, few studies focused on Ni-based for...
Our purpose was to explore whether <sup>68</sup>Ga-PSMA PET/CT alone (PET/CT) or in combination with multiparametric MRI (PET/MRI) can improve the detection of clinically significant prostate cancer (PCa). <b>Methods:</b> We retrospectively enrolled 54 patients who underwent both and before radical prostatectomy. Regions interest on MR images, pathologic images were marked. A lesion defined as a region marked obtained any 3 modalities. All lesions characterized using imaging reporting data...
Highly stable circulating microRNAs (miRNAs) are currently recognized as a novel potential biomarker for clinical cancer diagnosis in the early stage. However, limited by its low concentration, high sequence similarity, well numerous interferences body fluids, detection of miRNA whole blood with sufficient selectivity and sensitivity is still challenging. Herein, we reported integration entropy-driven toehold-mediated DNA strand displacement (ETSD) reaction magnetic beads (MB) toward...
Oxidative stress induced by hyperglycemia or chronic inflammation can limit diabetic wound healing, resulting in foot ulcers. Hydrogen has the potential to act as an antioxidant and scavenge reactive oxygen species, thereby attenuating these wounds. However, most of reported H2 delivery systems for including hydrogen gas, hydrogen-rich water, saline, are very short-lived low solubility gas. Here, we introduce a hydrogen-producing hydrogel made living Chlorella bacteria within...
To evaluate the diagnostic value of 68Ga-PSMA-11 PET-CT with multiparametric magnetic resonance imaging (mpMRI) for lymph node (LN) staging in patients intermediate- to high-risk prostate cancer (PCa) undergoing radical prostatectomy (RP) pelvic dissection (PLND). We retrospectively identified 42 consecutive PCa according D′Amico and without concomitant cancer. Preoperative PET-CT, mpMRI subsequent robot assisted laparoscopic RP PLND were performed all patients. Among assessed, preoperative...
Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), two immunosuppressive myeloid components within the tumor microenvironment (TME), represent fundamental barriers in cancer immunotherapy, whereas current nanomedicines rarely exert dual modulatory roles on these cell types simultaneously. Reactive oxygen species (ROS) not only mediates MDSC-induced immunosuppression but also triggers differentiation polarization of M2-TAMs. Herein, an ROS scavenging nanozyme,...
Several natural Chinese herbal medicines have demonstrated considerable potential in facilitating wound healing, while the primary concern remains centered around optimizing formulation and structure to maximize their efficacy. To address this, a microneedles drug delivery system is proposed that harnesses gelatinized starch key ingredients-aloe vera berberine. After aged well-designed mold, starch-based are fabricated with suitable mechanical strength load components. The resulting hydrogel...