A5102000748- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- PARP inhibition in cancer therapy
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Viral Infectious Diseases and Gene Expression in Insects
- Dental Implant Techniques and Outcomes
- Carbon and Quantum Dots Applications
- Dental materials and restorations
- Nanoparticle-Based Drug Delivery
- Inhalation and Respiratory Drug Delivery
- Antimicrobial Peptides and Activities
- CAR-T cell therapy research
Nanjing Drum Tower Hospital
2019-2025
Nanjing University of Chinese Medicine
2022-2025
Nanjing University
2015-2024
Changchun Institute of Applied Chemistry
2024
State Key Laboratory of Polymer Physics and Chemistry
2024
Chinese Academy of Sciences
2024
Nanjing Medical University
2019-2022
State Key Laboratory of Pharmaceutical Biotechnology
2016-2022
State Key Laboratory of Analytical Chemistry for Life Science
2016-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Abstract Bladder cancer ranks as the 10th most common worldwide, with deteriorating prognosis disease advances. While immune checkpoint inhibitors (ICIs) have shown promise in clinical therapy both operable and advanced bladder cancer, identifying patients who will respond is challenging. Anoikis, a specialized form of cell death that occurs when cells detach from extracellular matrix, closely linked to tumor progression. Here, we aimed explore anoikis-based biomarkers for immunotherapeutic...
Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for deregulation of oncogenes and tumour suppressors in CRC vital its diagnosis, treatment, prognosis prevention. Hu antigen R (HuR), which highly upregulated CRC, functions as pivotal oncogene to promote progression. However, underlying cause dysregulation poorly understood. In tissue sample pairs, HuR protein levels were measured by Western blot immunohistochemical (IHC) staining, respectively. mRNA...
Conditionally replicating adenoviruses have emerged as novel therapeutic agents for cancer. This study aimed to evaluate synergistic antitumor activity of replication-competent adenovirus armed with interleukin (IL)-18 (ZD55-IL-18) and dacarbazine (DTIC) against melanoma. Melanoma A375 cells or nude mouse tumor xenografts were treated ZD55-IL-18 alone together DTIC. The results showed that competently replicated in expressed IL-18, these not affected by enhanced the cytotoxicity DTIC...
Treatment of bacterial biofilms remains a great challenge in the clinic. Recently, ultrasound (US)-driven antimicrobial sonodynamic therapy (aSDT) has been considered as an emerging therapeutic strategy for treatment biofilm infections. However, hypoxic microenvironment and restricted diffusion sonosensitizers within substantially reduce efficacy aSDT. Herein, microenvironment-responsive nanoplatform was proposed to promote degradation sonosensitizer penetration, relieve microenvironment,...
In this review, we summarize the recent advance of nanozymes in treatment bacterial infection.
Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), two immunosuppressive myeloid components within the tumor microenvironment (TME), represent fundamental barriers in cancer immunotherapy, whereas current nanomedicines rarely exert dual modulatory roles on these cell types simultaneously. Reactive oxygen species (ROS) not only mediates MDSC-induced immunosuppression but also triggers differentiation polarization of M2-TAMs. Herein, an ROS scavenging nanozyme,...
Traditional dendritic cell (DC)-mediated immunotherapy is usually suppressed by weak immunogenicity in tumors and generally leads to unsatisfactory outcomes. Synergistic exogenous/endogenous immunogenic activation can provide an alternative strategy for evoking a robust immune response promoting DC activation. Herein, Ti
Photocatalysis offers a direct, yet robust, approach to eradicate pathogenic bacteria. However, the practical implementation of photocatalytic disinfection faces significant challenge due low-efficiency photogenerated carrier separation and transfer. Here, we present an effective improve performance by exploiting pyro-phototronic effect through synergistic combination pyroelectric properties processes. A set comprehensive studies reveals that temperature fluctuation-induced field promotes...
Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, reduce for wound treatment is presented. These findings reveal Ag/PDAs exhibit broad‐spectrum...
The Pseudomonas aeruginosa biofilm in recalcitrant chronic lung infections not only develops high antimicrobial tolerance but also induces an aberrant host inflammatory response. metabolic condition plays a vital role both the susceptibility of bacteria and response immune cells, thereby offering potential therapeutic target. Herein, we described modulation strategy by using ultrasound-responsive liposomal nanoparticles containing sonosensitizer hypoxia-activated prodrug against...
Antimicrobial phototherapy has gained recognition as a promising approach for addressing bacterial biofilms, however, its effectiveness is often impeded by the robust physical and chemical defenses of biofilms. Traditional antibacterial nanoplatforms face challenges in breaching extracellular polymeric substances barrier to efficiently deliver photosensitizers deep into Moreover, prevalent hypoxia within biofilms restricts success oxygen-reliant phototherapy. In this study, we engineered...
Highlights•A multiethnic, multicentric, case–control study was conducted to identify serum miRNA signature for diagnosing NSCLC.•A five-miRNA-based classifier accurate diagnosis of NSCLC among patients Chinese and America constructed.•The five-miRNA panel allowed detection especially stage I–II cases from normal benign nodule subjects.Wang et al. constructed a which provides the potential study. More importantly, subjects. These results suggest that might be useful biomarker in ethnically...
Infection of H5N1 influenza virus causes the highest mortality among all viruses. The mechanisms underlying such high viral pathogenicity are incompletely understood. Here, we report that encodes a microRNA-like small RNA, miR-HA-3p, which is processed from stem loop-containing RNA precursor by Argonaute 2, and plays role in enhancing cytokine production during infection. Mechanistic study shows miR-HA-3p targets poly(rC)-binding protein 2 (PCBP2) suppresses its expression. Consistent with...
The incidence and mortality rate of renal cell carcinoma (RCC) have been significantly increasing; however, the mechanisms involved in RCC development progression are unclear. In this study, we found that miR-28-5p was decreased tumor specimens several lines. By using a combination luciferase reporter assays western blotting, identified RAP1B, Ras-related small GTP-binding oncoprotein implicated variety tumors, as direct target RCC. RAP1B protein level increased lines, inversely correlated...
BackgroundUrinary exosomal miRNAs are gaining increasing attention for their potential as ideal non-invasive biomarkers kidney diseases; however, little is known about diagnostic ability paediatric nephrotic syndrome (NS). This study explored the clinical value of urinary idiopathic NS.MethodsUrine samples were collected from 129 NS children and 126 age−/sex-matched healthy controls. The miRNA profile exosomes was analysed by high-throughput Illumina sequencing via synthesis (SBS) technology...
Abstract Background Bladder cancer is the most common malignant tumor of urinary system. Surgical resection and chemotherapy are two mainstream treatments for bladder cancer. However, outcomes not satisfactory patients with advanced There a need to further explore more effective targeted therapeutic strategies. Methods Proteomics were performed compare protein expression differences between human tissues adjacent normal tissues. The function GPD1 on cells confirmed through in vivo vitro...