A5078678246- Inflammatory Bowel Disease
- Prostate Cancer Treatment and Research
- Plant-based Medicinal Research
- Ginger and Zingiberaceae research
- Cancer-related molecular mechanisms research
- Natural product bioactivities and synthesis
- Spondyloarthritis Studies and Treatments
- Nanoparticle-Based Drug Delivery
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Gut microbiota and health
- Rheumatoid Arthritis Research and Therapies
- Chromatography in Natural Products
- Cancer Research and Treatments
- Cancer-related gene regulation
- X-ray Diffraction in Crystallography
- RNA Interference and Gene Delivery
- Crystallization and Solubility Studies
- Cancer, Lipids, and Metabolism
- Microscopic Colitis
- MicroRNA in disease regulation
- Advanced Drug Delivery Systems
- Drug Transport and Resistance Mechanisms
- Immune Response and Inflammation
- Plant Molecular Biology Research
Yunnan Agricultural University
2023-2025
Georgia State University
2014-2024
Binzhou University
2015-2024
Binzhou Medical University
2015-2024
Veterans Health Administration
2021-2024
Jiangxi Academy of Sciences
2024
Nanchang University
2024
Target (United States)
2024
China Academy of Building Research
2024
Second Affiliated Hospital of Nanchang University
2024
MicroRNA319 (miR319) is one of the first characterized and conserved microRNA families in plants has been demonstrated to target TCP (for TEOSINTE BRANCHED/CYCLOIDEA/PROLIFERATING CELL FACTORS [PCF]) genes encoding plant-specific transcription factors. MiR319 expression regulated by environmental stimuli, suggesting its involvement plant stress response, although experimental evidence lacking underlying mechanism remains elusive. This study investigates role that miR319 plays response...
MicroRNA319 (miR319) family is one of the conserved microRNA (miRNA) families among diverse plant species. It has been reported that miR319 regulates development in dicotyledons, but little known at present about its functions monocotyledons. In rice (Oryza sativa L.), MIR319 gene comprises two members, Osa-MIR319a and Osa-MIR319b. Here, we report an expression pattern analysis a functional characterization Osa-MIR319 genes rice. We found overexpressing Osa-MIR319b both resulted wider leaf...
Plant-derived edible nanoparticles (PDNPs) are nano-sized membrane vesicles released by plants, such as grapefruit, ginger, broccoli, and lemon.
Phytochemical complexity of plant extracts may offer health-promoting benefits including chemotherapeutic and chemopreventive effects. Isolation 'most-active fraction' or single constituents from whole not only compromise the therapeutic efficacy but also render toxicity, thus emphasizing importance preserving natural composition extracts. The leaves Annona muricata, commonly known as Graviola, are to be rich in flavonoids, isoquinoline alkaloids annonaceous acetogenins. Here, we demonstrate...
Conditionally replicating adenoviruses have emerged as novel therapeutic agents for cancer. This study aimed to evaluate synergistic antitumor activity of replication-competent adenovirus armed with interleukin (IL)-18 (ZD55-IL-18) and dacarbazine (DTIC) against melanoma. Melanoma A375 cells or nude mouse tumor xenografts were treated ZD55-IL-18 alone together DTIC. The results showed that competently replicated in expressed IL-18, these not affected by enhanced the cytotoxicity DTIC...
The shape of grass leaves possesses great value in both agronomy and developmental biology research. Leaf rolling is one the important traits rice (Oryza sativa L.) breeding. MYB transcription factors are largest gene families have roles plant development, metabolism stress responses. However, little known about their functions rice. In this study, we report functional characterization a gene, OsMYB103L, which encodes an R2R3-MYB factor. OsMYB103L was localized nucleus with transactivation...
Docetaxel is the only FDA-approved first-line treatment for castration-resistant prostate cancer (CRPC) patients. inevitably leads to tumour recurrence after an initial therapeutic response with generation of multinucleated polyploid (MP) cells. Here we investigated role MP cells in clinical relapse CRPC.Prostate (PC-3) were treated docetaxel (5 nM) 3 days followed by a washout and samples collected at close intervals over 35 post drug washout. The tumorigenic potential giant was studied...
Ulcerative colitis (UC), a subtype of inflammatory bowel disease (IBD), has evolved into global burden given its high incidence. There is clinical need to create better diagnostic and therapeutic approaches UC.We fabricated P-selectin binding peptide-decorated poly lactic-co-glycolic acid (PBP-PLGA-NP) doped with two lipophilic dyes, DiL DiD. Meanwhile, low-toxic anti-inflammatory natural products (betulinic [BA] resveratrol [Res]) were co-loaded in the PBP-PLGA-NP system. The BA/Res-loaded...
In order to solve the problem of precise identification and counting tea pests, this study has proposed a novel pest method based on improved YOLOv7 network.
Nanoparticles (NPs) have been utilized to deliver drugs the intestinal epithelium in vivo. Moreover, NPs derived from edible plants are less toxic than synthetic NPs. Here, we ginger NP-derived lipid vectors (GDLVs) a proof-of-concept investigation test hypothesis that inhibiting expression of divalent metal-ion transporter 1 (Dmt1) would attenuate iron loading mouse model hereditary hemochromatosis (HH). Initial experiments using duodenal epithelial organ cultures intestine-specific Dmt1...
Inflammatory bowel diseases (IBD) etiology is multifactorial. Luminal microRNAs (miRNAs) have been suspected to play a role in the promotion of chronic inflammation, but extent which fecal miRNAs are interacting with intestinal ecosystem way that contribute diseases, including IBD, remains unknown. Here, let-7b and miR-21 were found elevated, associated correlating multiple bacteria IBD patients IL-10–/– mice, model spontaneous colitis. Using an vitro microbiota modeling system, we revealed...
Objective. To submit serum levels of matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) to statistical analyses test their exact degrees clinical usefulness as biomarkers for detecting high disease activity in ankylosing spondylitis (AS), comparing them with erythrocyte sedimentation rate (ESR) C-reactive protein (CRP).
Abstract Background Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as the global chromatin organizer to regulate structure and gene expression expression. SATB1 has been shown be abnormally expressed in various types of cancer. However, role prostate cancer remain unclear. Methods 120 cases prostatic carcinoma 60 benign hyperplasia were analyzed for by immunohistochemistry. LNCaP, DU-145, PC3 cells examined Western blot analysis. Cell proliferation...