A5102919303- Atomic and Subatomic Physics Research
- Congenital Diaphragmatic Hernia Studies
- Advanced MRI Techniques and Applications
- Scoliosis diagnosis and treatment
- Lung Cancer Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Cardiac electrophysiology and arrhythmias
- Epilepsy research and treatment
- Cancer-related molecular mechanisms research
- Medical Image Segmentation Techniques
- Transplantation: Methods and Outcomes
- Reproductive Biology and Fertility
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastroesophageal reflux and treatments
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Ultrasound in Clinical Applications
- MicroRNA in disease regulation
- Neural dynamics and brain function
- Advanced Neural Network Applications
- Liver Disease and Transplantation
- Epigenetics and DNA Methylation
University of Pennsylvania
2016-2025
First Hospital of Qinhuangdao
2025
Nanjing Medical University
2017-2024
First Affiliated Hospital of Anhui Medical University
2021-2024
Anhui Medical University
2021-2024
Ministry of Education of the People's Republic of China
2024
Nanjing Brain Hospital
2017-2024
Zhejiang University of Technology
2023-2024
Children's Hospital of Philadelphia
2024
California University of Pennsylvania
2017-2024
The International Council on Harmonization (ICH) S7B and E14 regulatory guidelines are sensitive but not specific for predicting which drugs pro‐arrhythmic. In response, the Comprehensive Vitro Proarrhythmia Assay (Ci PA ) was proposed that integrates multi‐ion channel pharmacology data in vitro into a human cardiomyocyte model silico proarrhythmia risk assessment. Previously, we reported optimization metric selection based Ci training drugs. this study, report application of prespecified to...
Background and Aim Circulating microRNAs (miRNAs) are potential biomarkers for cancer detection; however, little is known about their prognostic impact on oesophageal squamous cell carcinoma (ESCC). The current study aims to uncover novel miRNAs in ESCC patients. Patients Methods We initially screened the expression of 754 serum using TaqMan Low Density Array two pooled samples respectively from 28 normal controls. Markedly upregulated some reported be differently expressed tissue were then...
The incidence and mortality rate of renal cell carcinoma (RCC) have been significantly increasing; however, the mechanisms involved in RCC development progression are unclear. In this study, we found that miR-28-5p was decreased tumor specimens several lines. By using a combination luciferase reporter assays western blotting, identified RAP1B, Ras-related small GTP-binding oncoprotein implicated variety tumors, as direct target RCC. RAP1B protein level increased lines, inversely correlated...
hERG block potency is widely used to calculate a drug's safety margin against its torsadogenic potential. Previous studies are confounded by use of different patch clamp electrophysiology protocols and lack statistical quantification experimental variability. Since the new cardiac paradigm being discussed International Council for Harmonisation promotes tighter integration nonclinical clinical data risk assessment, more systematic approach estimate needed. A cross-industry study was...
Background Available methods to quantify regional dynamic thoracic function in insufficiency syndrome (TIS) are limited. Purpose To evaluate the use of quantitative MRI depict changes before and after surgical correction TIS. Materials Methods Images from free-breathing pediatric patients with TIS (July 2009-August 2015) were retrospectively evaluated by using vertical expandable prosthetic titanium rib (VEPTR). Eleven volumetric parameters derived lung, chest wall, diaphragm segmentations,...
We applied a set of in silico and vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess risk chloroquine (CLQ) or hydroxychloroquine (OH-CLQ)-mediated QT prolongation Torsades de Pointes (TdP), alone combined erythromycin (ERT) azithromycin (AZI), drugs repurposed during first wave coronavirus disease 2019 (COVID-19). Each drug combination was tested patch clamp assays on seven cardiac ion channels, models human ventricular electrophysiology...
Novel 2-arylmethoxy-4-(2,2′-dihalogen-substituted biphenyl-3-ylmethoxy) benzylamine derivatives were designed, synthesized, and evaluated in vitro vivo against cancers as PD-1/PD-L1 inhibitors. Through the computer-aided structural optimization homogeneous time-resolved fluorescence (HTRF) assay, compound A56 was found to most strongly block interaction with an IC50 value of 2.4 ± 0.8 nM showed potent activity. 1H NMR titration results indicated that can tightly bind PD-L1 protein KD < 1 μM....
Purpose To investigate free-breathing thoracic bright-blood four-dimensional (4D) dynamic MRI (dMRI) to characterize aeration of parenchymal lung tissue in healthy children and patients with insufficiency syndrome (TIS). Materials Methods All dMR images TIS were collected from July 2009 June 2017. Standardized signal intensity (sSI) was investigated, first using a phantom establish feasibility sensitivity then retrospective research study 40 (16 male, 24 female; mean age, 9.6 years ± 2.1...
Primary sarcomatoid carcinoma of the uterus is a rare and highly malignant neoplasm with poor prognosis. Herein, we reported case uterine in 55-year-old woman colporrhagia for 1 month. 18 F-FDG PET/CT showed intense uptake tumor hypermetabolic pelvic lymph node pulmonary nodules. Histopathology immunohistochemistry lesion tissue confirmed diagnosis after needle biopsy.
Overweight and underweight conditions are considered relative contraindications to lung transplantation due their association with excess mortality. Yet, recent work suggests that body mass index (BMI) does not accurately reflect adipose tissue in adults advanced diseases. Alternative more accurate measures of adiposity needed. Chest fat estimation by routine computed tomography (CT) imaging may therefore be important for identifying high-risk transplant candidates. In this paper, an...
Quantitative analysis of the regional motion left hemi-diaphragm (LHD) and right (RHD) can provide information regarding distribution severity abnormalities in individual patients with conditions that affect respiration such as thoracic insufficiency syndrome (TIS). Such be captured effectively from dynamic magnetic resonance imaging (dMRI) which does not involve ionizing radiation obtained under free-breathing conditions. The performed on diaphragm using 4D images constructed dMRI, turn...
This retrospective study aims to assess the adjunctive efficacy of warm needle moxibustion and gua sha care in treatment eszopiclone tablets on sleep quality psychological stress insomnia patients. Data 138 patients from Gansu Baoshihua hospital between January December 2022 were collected. Patients bifurcated into 2 groups: those solely treated with (n = 71) administered a combined regimen eszopiclone, moxibustion, 67). Sleep quality, stress, daytime drowsiness assessed using Pittsburgh...