A5050640186- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Pulmonary Hypertension Research and Treatments
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoacoustic and Ultrasonic Imaging
- Cerebrospinal fluid and hydrocephalus
- Spinal Fractures and Fixation Techniques
- Fuel Cells and Related Materials
- Metal-Organic Frameworks: Synthesis and Applications
- Cell Image Analysis Techniques
- Facial Trauma and Fracture Management
- Adsorption and biosorption for pollutant removal
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Thermoregulation and physiological responses
- Advanced Radiotherapy Techniques
- MXene and MAX Phase Materials
- Nuclear Receptors and Signaling
- Cardiac electrophysiology and arrhythmias
- Neuroscience of respiration and sleep
- Single-cell and spatial transcriptomics
- Optical Coherence Tomography Applications
State Key Laboratory of Pollution Control and Resource Reuse
2021-2025
Sichuan University
2014-2025
Renmin Hospital of Wuhan University
2025
Wuhan University
2025
Nanjing University
2014-2025
First Affiliated Hospital of Xi'an Jiaotong University
2024
State Key Laboratory of Food Science and Technology
2024
Jiangnan University
2024
Shenyang Institute of Automation
2024
Chinese Academy of Sciences
2018-2024
Photodynamic therapy (PDT) is an emerging effective treatment for cancer. However, the great promise of PDT bladder cancer has not yet been realized because tumor hypoxia. To address this challenge, we fabricated O2-generating HSA-MnO2-Ce6 NPs (HSA human serum albumin, Ce6 chlorin e6, and nanoparticles) to overcome hypoxia thus enhance photodynamic effect therapy. Methods: The were prepared. We investigated O2 generation in vitro vivo. orthotopic model C57BL/6 mice was established vivo...
Patients with asthma experience circadian variations in their symptoms. However it remains unclear how specific aspects of this common airway disease relate to clock genes, which are critical the generation rhythms mammals. Here, we used a viral model acute and chronic examine disruption affects asthmatic lung phenotypes. Deletion core gene bmal1 or environmental function by jet lag exacerbated bronchiolitis caused Sendai virus (SeV) influenza A mice. Post-natal deletion was sufficient...
Haploinsufficiency of the SLC2A1 gene and paucity its translated product, glucose transporter-1 (Glut1) protein, disrupt brain function cause neurodevelopmental disorder, Glut1 deficiency syndrome (Glut1 DS). There is little to suggest how reduced causes cognitive dysfunction no optimal treatment for DS. We used model mice demonstrate that low protein arrests cerebral angiogenesis, resulting in a profound diminution microvasculature without compromising blood-brain barrier. Studies define...
Abstract Neurovascular coupling, cerebrovascular remodeling and hemodynamic changes are critical to brain function, dysregulated in neuropathologies such as tumors. Interrogating these phenomena freely behaving animals requires a portable microscope with multiple optical contrast mechanisms. Therefore, we developed miniaturized with: fluorescence (FL) channel for imaging neural activity (e.g., GCaMP) or fluorescent cancer cells 9L-GFP); an intrinsic signal (IOS) hemoglobin absorption (i.e.,...
Adsorption as a desalination approach has the advantages of energy efficiency, low cost, and operational convenience, but its practical application is limited by capacity, consumption/disposal strong acids/bases regeneration reagents, poor reusability. Herein, we synthesized thermo-regenerable salt absorbent grafting ethylenediaminetetraacetic acid (EDTA) onto metal–organic framework (MOF), MOF-808-EDTA, which could rapidly adsorb NaCl within 30 min from saline water at 25 °C with capacity...
Artificial ion channel membranes hold high promise in water treatment, nanofluidics, and energy conversion, but it remains a great challenge to construct such smart with both reversible ion-gating capability desirable selectivity. Herein, we constructed MXene-based membrane via p-phenylenediamine functionalization (MLM-PPD) highly stable aligned two-dimensional subnanochannels, which exhibits ultrahigh metal selectivity similar biological channels. The pH-sensitive groups within the MLM-PPD...
Fibroblast growth factor homologous factors (FHFs), among other fibroblast factors, are increasingly found to be important regulators of ion channel functions. Although FHFs have been link several neuronal diseases and arrhythmia, its role in inflammatory pain still remains unclear. This study aimed investigate the mechanism FGF13 pain. Fgf13 conditional knockout mice were generated CFA-induced chronic model was established measure threshold. Immunostaining, western blot quantitative...
Abstract Carotene hydroxylases catalyze the hydroxylation of α‐ and β‐carotene hydrocarbons into xanthophylls. In red algae, is a ubiquitously distributed carotenoid, hydroxylated carotenoids such as zeaxanthin lutein are also found. However, no enzyme with carotene hydroxylase activity had been previously identified in algae. Here, we report isolation gene encoding cytochrome P450‐type ( PuCHY1 ) from Porphyra umbilicalis , alga an ancient origin. Sequence comparisons found belongs to...
Mild hypothermia (MH) and edaravone (EDA) exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury through activation of the nuclear factor erythroid 2‑related 2 (Nrf2) pathway. However, whether MH EDA synergistic I/R remains unknown. The aim present study was to investigate mechanism action in combination with injury. A rat model constructed by middle artery occlusion (MCAO) followed reperfusion, mice were treated MH, or inhibitor Nrf2 signaling pathway brusatol...
Paucity of the glucose transporter-1 (Glut1) protein resulting from haploinsufficiency SLC2A1 gene arrests cerebral angiogenesis and disrupts brain function to cause Glut1 deficiency syndrome (Glut1 DS). Restoring DS model mice prevents disease, but precise cellular sites action transporter, its temporal requirements, mechanisms linking scarcity cell dysfunction remain poorly understood. Here, we show that functions in a cell-autonomous manner microvasculature affect endothelial tip cells...
Objective: To evaluate the altered expression of peripheral clock genes, circulating melatonin levels, and their correlations with sleep-wake phenotypes including probable rapid eye movement sleep behavior disorder (pRBD) symptoms in a relatively large population Parkinson's disease (PD) patients. Methods: We determined profiles five principal BMAL1, CLOCK, CRY1, PER1, PER2, blood mononuclear cells (PBMCs) PD patients (n = 326), healthy controls (HC, n 314) using quantitative real-time PCR....