A5102704969- Advanced Nanomaterials in Catalysis
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Research and Splicing
- Hepatitis C virus research
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Bone Tissue Engineering Materials
- Nanocluster Synthesis and Applications
- Photodynamic Therapy Research Studies
- Electrochemical sensors and biosensors
- Chronic Myeloid Leukemia Treatments
- Cancer and Skin Lesions
- Epigenetics and DNA Methylation
- Graphene and Nanomaterials Applications
- Cancer, Lipids, and Metabolism
- Virus-based gene therapy research
- Advanced biosensing and bioanalysis techniques
- Hematopoietic Stem Cell Transplantation
- Breast Lesions and Carcinomas
- Circular RNAs in diseases
- Diet and metabolism studies
- RNA modifications and cancer
- Breast Cancer Treatment Studies
China Medical University
2024
Second Xiangya Hospital of Central South University
2014-2024
Central South University
2014-2024
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2024
Southern Medical University
2021
Nanjing University
2009-2021
Collaborative Innovation Center of Advanced Microstructures
2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Shanghai Blood Center
2009-2017
Haikou City People's Hospital
2015-2016
Reactive oxygen species (ROS)-induced oxidative stress is linked to various diseases, including cardiovascular disease and cancer. Though highly efficient natural ROS scavenging enzymes have been evolved, they are sensitive environmental conditions hard mass-produce. Therefore, enormous efforts devoted developing artificial with activities. Among them, nanozymes recently attracted great interest owing their enhanced stability, multi-functionality, tunable activity. It has implicated that...
Catalytic nanomaterials with intrinsic enzyme-like activities, called nanozymes, have recently attracted significant research interest due to their unique advantages relative natural enzymes and conventional artificial enzymes.Among the nanozymes developed, particular interests been devoted peroxidase mimicking activities because of promising applications in biosensing, bioimaging, biomedicine, etc. Till now, lots functional used mimic peroxidase.However, few studies focused on Ni-based for...
Abstract P73 antisense RNA 1T (TP73‐AS1 or PDAM) is a long non‐coding RNA, which can regulate apoptosis through regulation of p53 signaling‐related anti‐apoptotic genes. An abnormal change TP73‐AS1 expression was noticed in cancers. The effects breast cancer (BC) growth and the underlying mechanism remain unclear so far. In present study, effect BC cell lines clinical tumor samples detected as to reveal its role function. specifically upregulated tissues correlated poorer prognosis patients...
Breast cancer (BC) is one of the leading causes deaths worldwide and most common among women. In our previous study, we revealed that lncRNA TP73-AS1 promotes breast cell proliferation through directly binding to miR-200a. Herein, evaluated effect in invasion migration, further demonstrated direct between miR-200a, miR-200a 3'UTR ZEB1, an essential metastasis-related transcription factor. promoted ZEB1 expression via competing with for binding. Moreover, could bind promoter region activate...
Abstract Recently, reactive oxygen species (ROS) scavenging nanozymes have been developed as natural enzyme alternatives to treat inflammatory bowel disease (IBD) well other diseases. Among them, manganese oxide are advantageous because of remarkable biocompatibility and their good biodegradability. It is herein reported that phospholipid coated Mn 3 O 4 mimic both superoxide dismutase (SOD) catalase (CAT) effectively eliminate ROS exacerbate inflammation cause damages tissues organs. With...
A synergistic antibacterial system for polyglycolic acid scaffolds was constructed by cation exchange of montmorillonite (MMT) with Cu 2+ and then intercalation cetyltrimethylammonium bromide (CTAB) into the interlayer MMT.
microRNAs (miRNAs) are endogenous 19-25 nucleotide noncoding single-stranded RNAs that regulate gene expression by blocking the translation or decreasing stability of mRNAs. In this study, we showed miR-200a levels were decreased while mitochondrial transcription factor A (TFAM) mRNA increased in breast cancer (BC) tissues and cell lines, identified TFAM as a novel direct target miR-200a. Overexpression suppressed protein expression, mtDNA copy number, attenuated proliferation. Forced can...
Long non‑coding RNA (lncRNA) small nucleolar host gene 1 (SNHG1) was reported to be a critical regulator of tumorigenesis and is frequently deregulated in several cancer types. However, the exact mechanism by which SNHG1 contributes breast progression has not been fully elucidated. The identification molecular important for understanding development improving prognosis patients with this disease. In present study, increased expression levels were noted tumors following analysis...
The Dickkopf 3 (DKK3) protein antagonizes the Wnt receptor complex in signaling pathway; however, to date, there have been no relevant studies investigating its upstream regulatory mechanism breast cancer (BC), best of our knowledge. present study aimed explore whether long non‑coding RNA MICAL2‑1 (lnc‑MICAL2‑1) sponged microRNA (miR)‑25 regulate DKK3 and inhibit activation Wnt/β‑catenin pathway. Atlas Cancer database was used measure expression levels lnc‑MICAL2‑1 their correlation with...
It is controversial for prognosis of invasive micropapillary carcinoma (IMPC) compared with ductal (IDC) the breast. To better understand difference between IMPC and IDC prognoses, we conducted this retrospective study. Data from 33 patients were retrospectively reviewed, clinicopathologic characteristics survival status those 347 who treated during same period. The cases larger tumor size, greater proportion nodal involvement, an increased incidence lymphovascular invasion cases. overall...
The aim of the present study was to determine expression adenosine triphosphate binding cassette subfamily B member 1 (ABCB1) gene and its protein P‑glycoprotein (PGP) in bone marrow mononuclear cells from chronic myeloid leukemia (CML) patients with imatinib mesylate (IM) resistance, or IM‑resistant CML K562 cells. In addition, molecular mechanism action microRNA (miR)‑214 on ABCB1 IM resistance investigated. A total 26 were included study. 31 who did not have as control group. Bone...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies in humans, and its prognosis generally poor even after surgery. Many advances have been made to understand pathogenesis HCC; however, molecular mechanisms that lead hepatocarcinogenesis progression are still not clearly understood. Methods The expression DACT2 specimens from 30 paired HCCs an additional 61 HCC patients liver transplantation was evaluated by quantitative RT-PCR immunohistochemical...
Black phosphorous (BP) is recognized as an effective reinforcement for polymer scaffold because of its excellent mechanical property and biocompatibility. Nevertheless, poor stability in physiological environment limits application bone repair. In this work, BP was modified with dopamine by self-polymerization approach (donated BP@PDA) to improve stability, then introduced into poly-L-lactic acid (PLLA) fabricated selective laser sintering technology. Results showed the compressive tensile...
Background: Patient immune response is one of the main factors influencing hepatitis virus (HBV) eradication or chronicity. Our study aimed to investigate relationship between nutritional status and function, provide appropriate clinical diagnosis data for treatment patients with chronic B (CHB) cirrhosis. Methods: T lymphocyte subsets were tested using flow cytometry in 100 (48 CHB, 52 cirrhosis) 26 healthy individuals. Nutritional parameters analyzed including body mass index (BMI), blood...