A5048211064- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Magnesium Alloys: Properties and Applications
- Dental materials and restorations
- Additive Manufacturing and 3D Printing Technologies
- biodegradable polymer synthesis and properties
- Aluminum Alloys Composites Properties
- RNA modifications and cancer
- Dental Implant Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing Materials and Processes
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- MXene and MAX Phase Materials
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Advanced Photocatalysis Techniques
- Laser-Ablation Synthesis of Nanoparticles
- Titanium Alloys Microstructure and Properties
Central South University
2016-2025
Xiangya Hospital Central South University
2016-2025
Jiangxi University of Science and Technology
2020-2025
Hunan Cancer Hospital
2014-2024
Bengbu Medical College
2024
Zhejiang University of Technology
2023
Ministry of Education of the People's Republic of China
2021-2023
Third Xiangya Hospital
2013-2022
Huawei Technologies (United Kingdom)
2022
Henan University of Traditional Chinese Medicine
2022
Mg and its alloys have been identified as promising bone implant materials owing to their natural degradability, good biocompatibility favorable mechanical properties. Nevertheless, the too fast degradation rate usually results in a premature disintegration of integrity local hydrogen accumulation, which limit clinical repair application. In this work, current research status regarding implants was systematically reviewed. The relevant strategies enhance corrosion resistance, including...
The incorporation of hydroxyapatite (HAP) into poly-l-lactic acid (PLLA) matrix serving as bone scaffold is expected to exhibit bioactivity and osteoconductivity those the living bone. While too low degradation rate HAP/PLLA hinders activity because embedded HAP in PLLA difficult contact exchange ions with body fluid. In this study, biodegradable polymer poly (glycolic acid) (PGA) was blended fabricated by laser 3D printing accelerate degradation. results indicated that PGA enhanced weight...
Zinc (Zn) possesses desirable degradability and favorable biocompatibility, thus being recognized as a promising bone implant material. Nevertheless, the insufficient mechanical performance limits its further clinical application. In this study, reduced graphene oxide (RGO) was used reinforcement in Zn scaffold fabricated via laser additive manufacturing. Results showed that homogeneously dispersed RGO simultaneously enhanced strength ductility of scaffold. On one hand, ascribed to (i) grain...
Abstract It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, short life function replacement permanent regeneration repair. At present, bone transplantation has become the second largest surgery after blood transfusion, and artificial generates great hope for treatment of defect. In order defect, must have good biological properties sufficient mechanical properties, it should also shape matching site connected porous structure. For...
Poly (lactic acid) (PLA) with good biodegradability, biocompatibility and processability has a wide application prospect in bone tissue engineering. However, PLA exhibits very slow degradation rate, hindering the regeneration of new bone. In this study, mechanisms scaffold, including autocatalysis non-catalysis, end-chain random chain breaking, surface bulk degradation, were analyzed systematically, influence factors crystallinity, molecular weight, pH, so on, introduced. On basis,...
Photodynamic therapy (PDT) presented tremendous potential for combating implant-related infections, but its antibacterial efficacy was constrained by rapid electron–hole pair recombination of photosensitizers and barrier action a dense biofilm on reactive oxygen species (ROS). Herein, cascade phototherapeutic AuKN-LA nanosystem constructed depositing Au nanoparticles l-arginine (LA) potassium niobate (KN) photosensitizer. In the nanosystem, with lower Fermi levels could capture...
Lin28 acts as a repressor of microRNA processing and post-transcriptional regulatory factor for subset mRNAs. Here we report that in human embryonic stem cells facilitates the expression pivotal pluripotency Oct4 at level. We provide evidence binds mRNA directly through high affinity sites within its coding region an interaction between RNA helicase A (RHA) may play part observed regulation. further demonstrate decreasing RHA levels impairs Lin28-dependent stimulation translation reporter...
Lin28 inhibits the expression of let-7 microRNAs but also exhibits let-7-independent functions. Using immunoprecipitation and deep sequencing, we show here that preferentially associates with a small subset cellular mRNAs. Of particular interest are those for ribosomal proteins metabolic enzymes, levels which known to be coupled cell growth survival. Polysome profiling reporter analyses suggest stimulates translation many or most these targets. Moreover, Lin28-responsive elements were found...
Graphene is a novel material and currently popular as an enabler for the next-generation nanocomposites. Here, we report use of graphene to improve mechanical properties nano-58S bioactive glass bone repair regeneration. And composite scaffolds were fabricated by homemade selective laser sintering system. Qualitative quantitative analysis demonstrated successful incorporation into scaffold without obvious structural damage weight loss. The optimum compressive strength fracture toughness...
In this study, nano-hydroxyapatite scaffolds with high mechanical strength and an interconnected porous structure were prepared using NTSS for the first time. The step was performed a laser characterized by rapid heating to skip surface diffusion obtain driving force grain boundary diffusion. Additionally, achieved SLS. second consisted of isothermal in furnace at lower temperature (T2) than that beam further increase density suppress growth exploiting difference kinetics between...
Long noncoding RNAs (lncRNAs) have emerged as a major regulator of cancer. Significant fraction lncRNAs is represented on widely used microarray platforms; however, many which no known function. To discover novel lung cancer-related lncRNAs, we analyzed the lncRNA expression patterns in five sets previously published cancer gene profile data that were Affymetrix HG-U133 Plus 2.0 array, and identified dysregulated One lncRNA, actin filament associated protein 1 antisense RNA1 (AFAP1-AS1), was...
MicroRNAs have been considered as a kind of potential novel biomarker for cancer detection due to their remarkable stability in the blood and characteristics expression profile many diseases.We performed microarray-based serum miRNA profiling on twenty nasopharyngeal carcinoma patients at diagnosis along with 20 non-cancerous individuals controls. This was followed by real-time quantitative Polymerase Chain Reaction (RT-qPCR) separate cohort thirty age- matched volunteers. A model...
In present study, a strategy is presented to construct magnetic micro-environment in poly-l-lactide/polyglycolic acid (PLLA/PGA) scaffolds fabricated via selective laser sintering by incorporating Fe3O4 nanoparticles (MNPs), aiming enhance cell viability and promote bone regeneration. the micro-environment, each nanoparticle provides nanoscale field activate cellular responses. The results vitro demonstrated that not only stimulated adhesion viability, but also enhanced proliferation rate...