A5101939232- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Immune cells in cancer
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- Complement system in diseases
- Glycosylation and Glycoproteins Research
- Blood groups and transfusion
- Iron Metabolism and Disorders
- Cancer-related gene regulation
- Autoimmune and Inflammatory Disorders Research
- Platelet Disorders and Treatments
- Advanced Vision and Imaging
- Cancer-related molecular mechanisms research
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Parvovirus B19 Infection Studies
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- MicroRNA in disease regulation
Chengdu Medical College
2022-2025
Wuhan Union Hospital
2025
Huazhong University of Science and Technology
2008-2024
Guiyang Medical University
2024
Union Hospital
2019-2024
Shaoxing People's Hospital
2021-2023
Dalian Medical University
2023
Chongqing Medical University
2023
Second Affiliated Hospital of Chongqing Medical University
2023
Union Hospital
2022
Abstract Developing an excellent hemostatic material with good biocompatibility and high blood absorption capacity for rapid hemostasis of deep non‐compressible hemorrhage remains a significant challenge. Herein, novel conjugate electrospinning strategy to prepare ultralight 3D gelatin sponge consisting continuous interconnected nanofibers. This unique fluffy nanofiber structure endows the low density, surface area, compressibility, ultrastrong liquid capacity. In vitro assessments show has...
Summary The frequency and prognostic relevance of translocations t(11;14) t(4;14), the most common involving immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated 128 patients treated with intensive chemotherapy autologous stem cell transplant. Myeloma cells identified by cytoplasmic light immunofluorescence combined fluorescence situ hybridization (cIg‐FISH) for detection t(4;14). Overall, was detected 16 125 (12·8%) t(4;14) 15 120 (12·5%) patients....
Lupus nephritis (LN) is a representative manifestation in systemic lupus erythematosus (SLE). Some studies have shown that myeloid-derived suppressor cells (MDSCs) play vital role the regulation of SLE process. MDSC infiltration kidney as well inflammation and oxidative stress provokes acceleration deterioration LN. Nuclear factor E2-related 2 (Nrf2) thought to be major regulator antioxidant response. Baicalein flavonoid with known anti-inflammatory effects However, baicalein on MDSCs,...
Summary Central nervous system (CNS) involvement is an unusual manifestation in multiple myeloma (MM). The molecular basis of CNS poorly understood. MM characterized by translocations involving the immunoglobulin heavy chain (IgH) locus and frequent 13q deletions. Alterations p53 or c‐myc may represent secondary changes associated with disease progression. We investigated nine patients using interphase fluorescence situ hybridization (FISH) combined immunofluorescence detection cytoplasmic...
Myeloid-derived suppressor cells (MDSCs), including granulocytic (G)-MDSCs and monocytic (M)-MDSCs, play a critical role in tumor-induced T cell tolerance. MDSC immunosuppressive function differentiation are significantly promoted patients B-cell lymphoma model mice. However, the mechanisms regulating these processes remain largely unclear. In present study, we observed increased microRNA (miR)-30a expression both G-MDSCs M-MDSCs from B After transfection with miR-30a mimics, suppressive...
Electronic skin (e-skin) has attracted considerable interests to endow robots the abundant perception abilities like human skin. However, multifunctional tactile feedbacks and poor wearability hinder practical application towards compliant robot manipulations friendly human-robot interaction (HRI). Here, a 3D-shaped e-skin integrated with hierarchically distributed flexible pressure, proximity, humidity sensors, digital conversion circuits been developed via parting casting method. It can...
Abstract Background A series of studies have demonstrated the emerging involvement transfer RNA (tRNA) processing during progression tumours. Nevertheless, roles and regulating mechanisms tRNA genes in neuroblastoma (NB), prevalent malignant tumour outside brain children, are yet unknown. Methods Analysis multi‐omics results was conducted to identify crucial regulators downstream genes. Co‐immunoprecipitation mass spectrometry methods were utilised measure interaction between proteins. The...
The disruption of ferroptosis, an emerging form programmed cell death, is crucial in the development and aggressiveness tumors. Meanwhile, mechanisms treatments that control ferroptosis neuroblastoma (NB), a prevalent extracranial cancer children, are still unknown. In this study, forkhead box C1 (FOXC1) O-GlcNAc transferase (OGT) identified as regulators asparagine- alanine-mediated repression NB. Mechanistically, OGT facilitates FOXC1 stabilization via inducing O-GlcNAcylation liquid...
After early outbreaks in North America April 2009, the pandemic influenza A (H1N1) virus spread rapidly around world, and even some patients developed certain severe complications. We reported one case of hemophagocytic lymphohistiocytosis (HLH) induced by infection. 17-year-old girl had acute onset fever, dry cough, rhinorrhea, sore throat Her family members close friends also similar symptoms. Anti-infection treatment with penicillin was given after 8 days symptoms local hospital, her...
It is well known that when exposed to human blood plasma, nanoparticles are predominantly coated by a layer of proteins, forming corona will mediate the subsequent cell interactions. Magnetosomes protein-rich membrane which synthesized magnetic bacteria; these have gained lot attention owing their unique and biochemical characteristics. Nevertheless, whether bacterial magnetosomes after interacting with how such affects nanoparticle-cell interactions yet be elucidated. The aim this study was...
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by frequent 13q deletions and IgH translocations that have clinical prognostic significance. We evaluated clonal cells interphase fluorescence in situ hybridization (FISH) combined with immunofluorescence detection of cytoplasmic light chain (cIg-FISH) for the presence translocations. The FISH results were compared conventional cytogenetic analysis. Of 25 bone marrow specimens from MM patients, 11 (44%) had deletions. involving...
Intrauterine adhesions (IUA) are characterized by endometrial fibrosis and impose a great challenge for female reproduction. IL-34 is profoundly involved in various fibrotic diseases through regulating the survival, proliferation, differentiation of monocytes/macrophages. However, it remains unclear how regulates monocytes/macrophages context IUA. Here, we showed that expression level amount CX3CR1+ were significantly increased tissues IUA patients. promoted monocytes/macrophages, which...
Abstract Recent studies indicate that Toll-like receptors (TLRs) and C-type lectin (CLRs) can function as the signal of pattern recognition receptors, which play a pivotal role in pathogenesis autoimmune disease. Systemic lupus erythematosus (SLE) is classic Previous reports mainly focused on potential TLRs regulating development SLE, but little known about CLRs progression SLE. Our previous showed inflammation-mediated accumulation myeloid-derived suppressor cells (MDSCs) including...
Internal tandem duplication (ITD) mutations of FMS-like tyrosine kinase-3 (FLT3) are the most frequent genetic alterations in acute myeloid leukemia (AML) and predict a poor prognosis. FLT3 kinase inhibitors (TKIs) provide short-term clinical responses, but long-term prognosis FLT3/ITD+ AML patients remains poor. Notch signaling is important numerous types tumors. However, role to be elucidated. In current study, we found that was activated upon FLT3-TKI treatment cell lines primary cells....
Background: Emerging evidence has supported that intensive exercise induces weakened performance and immune metabolic disorders. We systematically evaluated the effects of quercetin against hepatic inflammatory damage caused by repeated explored potential mechanism. Methods: Male BALB/c mice were administered (100 mg/kg BW) for four weeks, performed a treadmill running protocol 28 m/min, 5° slope, 90 min/day concurrently last seven days. Results: Quercetin administration reduced leakage...
To investigate whether deoxynivalenol (DON) can induce intestinal damage through gut microbiota in mice.Mice are orally administered DON (1 mg kg-1 bw day-1 ) for 4 weeks, and then recipient mice receive fecal transplantation (FMT) from DON-exposed after antibiotic treatment. Furthermore, the treated with weeks Histological damage, disruption of tight junction protein expression, increased oxidative stress apoptosis colon as well higher serum lipopolysaccharides observed exposure. Moreover,...