A5083153761- Blood donation and transfusion practices
- Blood transfusion and management
- Hepatitis C virus research
- Blood groups and transfusion
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Folate and B Vitamins Research
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Acute Myeloid Leukemia Research
- Hemoglobinopathies and Related Disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related cognitive impairment studies
- Hematopoietic Stem Cell Transplantation
- HIV/AIDS Research and Interventions
- SARS-CoV-2 detection and testing
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Organ Donation and Transplantation
- Vaccine Coverage and Hesitancy
- Stroke Rehabilitation and Recovery
Population Health Research Institute
2002-2025
McMaster University
2001-2025
Jimei University
2025
University of Ottawa
2013-2024
Canadian Blood Services
2015-2024
University of South China
2022-2024
University of Toronto
2005-2022
Hawke's Bay Hospital
2021
Methodist Hospital
2018
IFC Research (United Kingdom)
2018
We studied whether aspirin resistance, defined as failure of suppression thromboxane generation, increases the risk cardiovascular events in a high-risk population.Baseline urine samples were obtained from 5529 Canadian patients enrolled Heart Outcomes Prevention Evaluation (HOPE) Study. Using nested case-control design, we measured urinary 11-dehydro B2 levels, marker vivo 488 cases treated with who had myocardial infarction, stroke, or death during 5 years follow-up and sex- age-matched...
Background —Activation of the renin-angiotensin-aldosterone system and oxidative modification LDL cholesterol play important roles in atherosclerosis. The Study to Evaluate Carotid Ultrasound changes patients treated with Ramipril vitamin E (SECURE), a substudy Heart Outcomes Prevention Evaluation (HOPE) trial, was prospective, double-blind, 3×2 factorial design trial that evaluated effects long-term treatment angiotensin-converting enzyme inhibitor ramipril on atherosclerosis progression...
Background Electrocardiographic markers of left ventricular hypertrophy (LVH) predict poor prognosis. We determined whether the ACE inhibitor ramipril prevents development and causes regression ECG-LVH these changes are associated with improved prognosis independent blood pressure reduction. Methods Results In Heart Outcomes Prevention Evaluation (HOPE) study, patients at high risk were randomly assigned to or placebo followed for 4.5years. ECGs recorded baseline study end. compared...
There is evidence that cognitive dysfunction, fatigue, and menopausal symptoms may occur in women receiving adjuvant chemotherapy for breast cancer. Here, we determine their incidence severity, interrelationships between them quality of life.In this study, 110 each nominated a female relative, friend, or neighbor (matched by age) as control; 100 eligible matched pairs were evaluated. Patients controls completed the following assessments: High-Sensitivity Cognitive Screen, Functional...
OBJECTIVES—Experimental and observational studies suggest that vitamin E may reduce the risk of cardiovascular (CV) events microvascular complications in people with diabetes. However, data from randomized clinical trials are limited. Therefore, we evaluated effects supplementation on major CV outcomes development nephropathy RESEARCH DESIGN AND METHODS—The Heart Outcomes Prevention Evaluation (HOPE) trial is a 2 × factorial design, which ramipril patients at high for events. Patients were...
Purpose We previously evaluated fatigue, menopausal symptoms, and cognitive dysfunction in patients receiving adjuvant therapy for breast cancer matched healthy women. Here we report assessment of these women 1 2 years later. Patients Methods without relapse controls were by the Functional Assessment Cancer Treatment-General Quality Life questionnaire, with subscales fatigue endocrine High Sensitivity Cognitive Screen. Results There 104, 91, 83 102, 81, 81 assessed at baseline years,...
The clustering of impaired glucose metabolism, elevated triglycerides, low HDL cholesterol, and abdominal obesity is known as the metabolic syndrome. Individuals with this syndrome suffer an excess cardiovascular disease (CVD) for reasons that are unclear.We randomly sampled 1276 adults South Asian, Chinese, European, Native Indian ancestry from 4 communities in Canada. Participants provided fasting blood samples glucose, lipids, fibrinolytic measurements; had oral tolerance test; underwent...
Small increases in the inflammatory marker C-reactive protein (CRP) are predictive of vascular events among asymptomatic individuals. There few data supporting use CRP as a risk nonwhite individuals.1250 adults South Asian, Chinese, European, and Aboriginal ancestry were randomly sampled from 4 communities Canada. Participants provided fasting blood samples for CRP, glucose, lipids, coagulation factors, they had undergone carotid B-mode ultrasound. Cardiovascular disease was determined by...
Summary The frequency and prognostic relevance of translocations t(11;14) t(4;14), the most common involving immunoglobulin heavy chain (IgH) gene in multiple myeloma (MM), were investigated 128 patients treated with intensive chemotherapy autologous stem cell transplant. Myeloma cells identified by cytoplasmic light immunofluorescence combined fluorescence situ hybridization (cIg‐FISH) for detection t(4;14). Overall, was detected 16 125 (12·8%) t(4;14) 15 120 (12·5%) patients....
Many patients with prostate cancer receive androgen deprivation therapy for long periods. We compared physical and cognitive function, quality of life in a cross-sectional study 57 receiving nonmetastatic 51 healthy age matched controls.Physical daily function were measured by the 6-minute walk test, grip strength, timed up go activities living measures. Cognitive was evaluated High Sensitivity Screen self-report prototype Functional Assessment Cancer Therapy subscale. Quality assessed...
New testing methods such as nucleic acid amplification (NAT) and chemiluminescent serologic assays have been introduced, more precise estimates for infectious window periods are available, a new method estimating the residual risk (RR) of transfusion-transmitted infections (TTIs) has developed. Thus, available RR Canada need to be updated.Incidence rates known TTI markers were determined all allogeneic whole-blood donations made Canadian Blood Services between 2001 2005; they derived from...
The inability to effectively treat biofilm-related infections is a major clinical challenge. This has been attributed the heightened antibiotic tolerance conferred bacterial cells embedded within biofilms. Lytic bacteriophages (phages) have evolved infect and eradicate biofilm-associated cells. current study was designed investigate ability of phage treatment enhance activity antibiotics against biofilm-forming Staphylococcus aureus. biofilm positive S. aureus strain ATCC 35556, lytic...
The prognosis of patients with atrial fibrillation (AF) and ischemic stroke while taking oral anticoagulation is poorly understood. This study aimed to characterize the outcomes following a event on anticoagulation.
In trials of patients with left ventricular dysfunction or heart failure, ACE inhibitor use was unexpectedly associated reduced myocardial infarction (MI). Using the Heart Outcomes Prevention Evaluation (HOPE) trial data, we tested prospectively whether ramipril, an inhibitor, could reduce coronary events and revascularization procedures among normal function.In HOPE trial, 9297 high-risk men women, >/=55 years age previous cardiovascular disease diabetes plus 1 risk factor, were randomly...
Background and Purpose— Activation of endothelial cells platelets is an important mediator atherothrombosis. Markers cell platelet activation such as soluble adhesion molecules can be measured in plasma. We hypothesized that patients with acute ischemic stroke would have increased blood concentrations E-selectin von Willebrand factor (vWF), primarily reflecting cells, P-selectin platelet-derived microvesicles (PDM), platelets, compared healthy controls. also these markers differentially...