A5100736923- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- Virus-based gene therapy research
- Autophagy in Disease and Therapy
- Bacteriophages and microbial interactions
- Ubiquitin and proteasome pathways
- Animal Disease Management and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Oral Health Pathology and Treatment
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Influenza Virus Research Studies
- HER2/EGFR in Cancer Research
- Reproductive tract infections research
- Birth, Development, and Health
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Vibrio bacteria research studies
- RNA Research and Splicing
Shanghai Chest Hospital
2025
Shanghai Jiao Tong University
2019-2025
University of Shanghai for Science and Technology
2025
Wuxi People's Hospital
2022-2024
Nanjing Medical University
2022-2024
China Agricultural University
2014-2024
Tianjin Medical University
2009-2024
Tianjin First Center Hospital
2019-2024
Yunnan University of Traditional Chinese Medicine
2024
Ministry of Agriculture and Rural Affairs
2022-2024
The high mortality and disability of diabetic nonhealing skin ulcers create an urgent need for the development more efficacious strategies targeting wound healing. In current study, using human clinical specimens, we show that perilesional tissues from patients with diabetes are under severe oxidative stress display higher activation nuclear factor-E2-related factor 2 (NRF2)-mediated antioxidant response than normoglycemic patients. a streptozotocin-induced mouse model, Nrf2(-/-) mice have...
Abstract Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses vaccines. To date, only a few approved use humans, among which aluminum-containing are the ones widely used. However, medical need potent and safe is currently continuously increasing, especially those triggering cellular cytotoxic T lymphocyte activation, urgently needed development efficient virus cancer Manganese an essential micronutrient required diverse biological...
We previously demonstrated that neurotensin (NTS) induces local inflammation and promotes tumor invasion in hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms are not clear. In this study, positive correlations between NTS interleukin (IL)-8 were identified at both mRNA protein levels 71 fresh HCC tissues 100 paraffin-embedded tissues. Furthermore, significant determined among co-expression of IL-8, infiltration inflammatory cells enhanced epithelial-mesenchymal...
The mechanism of action synovitis, as the vital pathological process rheumatoid arthritis and osteoarthritis, remains to be elucidated. effects icariin (ICA), which is a promising therapeutic agent in was investigated present study. In addition, ferroptosis, cell involved several diseases, also studied synovitis for first time. Lipopolysaccharide (LPS)‑induced synoviocytes served model. cells were divided into control, LPS experimental groups treated with different concentrations ICA. Cell...
Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed...
Adaptation of the viral polymerase complex comprising PB1, PB2, and PA is necessary for efficient influenza A virus replication in new host species. We found that mutation K356R (PA-K356R) has become predominant since 2014 avian H9N2 viruses China as with seasonal human H1N1 viruses. The same also most isolates emergent H7N9 H10N8 whose six internal gene segments are derived from virus. further demonstrated mammalian adaptive functionality PA-K356R mutation. Avian A549 cells showed increased...
The central region of MDM2 is critical for p53 activation and tumor suppression. Upon ribosomal stress, this bound by proteins, particularly protein L11 (RPL11), leading to inactivation subsequent activation. Here, we solved the complex structure human MDM2–RPL11 at 2.4 Å. extensively interacts with RPL11 through an acidic domain two zinc fingers. Formation induces substantial conformational changes in both proteins. RPL11, unable bind mutants, fails induce cells. mimics 28S rRNA binding...
Alphaherpesviruses that establish persistent infections rely partly on their ability to evade host antiviral responses, notably the type I interferon (IFN) response. However, mechanisms employed by alphaherpesviruses avoid this response are not well understood. Pseudorabies virus (PRV) is an economically important pathogen and a useful model system for studying alphaherpesvirus biology. To identify PRV proteins antagonize IFN signaling, we performed screen using IFN-stimulated element...
Accumulating evidence shows that curcumin exerts antitumor activities in a variety of malignancies. High mobility group box 1 (HMGB1) is associated with vascular endothelial growth factor D (VEGF-D)–induced lymphangiogenesis and tumor metastasis gastric cancer. However, the molecular mechanisms by which regulates HMGB1-mediated cancer remain unclear. In this study, cytotoxic effects were investigated AGS SGC-7901 cell lines MTT assay, curcumin-induced morphological changes apoptosis assessed...
Type I interferon response plays a prominent role against viral infection, which is frequently disrupted by viruses. Here, we report Bcl-2 associated transcription factor 1 (Bclaf1) degraded during the alphaherpesvirus Pseudorabies virus (PRV) and Herpes simplex type (HSV-1) infections through protein US3. We further reveal that Bclaf1 functions critically in signaling. Knockdown or knockout of cells significantly impairs interferon-α (IFNα) -mediated gene inhibition US3 deficient PRV HSV-1....
This study aimed to develop a rapid and sensitive droplet digital PCR (ddPCR) assay for the specific detection of Klebsiella pneumoniae in fecal samples, evaluate its application clinic by comparison with real-time conventional microbial culture. Specific primers probe targeting K. hemolysin (khe) gene were designed. Thirteen other pathogens used specificity probe. A recombinant plasmid containing khe was constructed assess sensitivity, repeatability, reproducibility ddPCR. Clinical samples...
Abstract Alphaherpesviruses are large dsDNA viruses with an ability to establish persistent infection in hosts, which rely partly on their evade host innate immune responses, notably the type I IFN response. However, relevant molecular mechanisms not well understood. In this study, we report UL42 proteins of alphaherpesvirus pseudorabies virus (PRV) and HSV 1 (HSV1) as a potent antagonist IFN-I–induced JAK-STAT signaling pathway. We found that ectopic expression porcine macrophage CRL human...
ABSTRACT Published data indicate that the protease‐activated receptor (PAR) 2 is involved in pathogenesis of some cardiovascular diseases; underlying mechanism to be further investigated. Ve‐cadherin a critical molecule maintaining endothelial barrier integrity. This study aims investigate role PAR2 activation compromising cardiac function. In this study, human umbilical vein cells (Huvec cells) were cultured into monolayers using as an vitro model The transepithelial electric resistance...