A5024755075- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Natural product bioactivities and synthesis
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Systemic Sclerosis and Related Diseases
- Chemokine receptors and signaling
- Morinda citrifolia extract uses
- Advanced Glycation End Products research
- Exercise and Physiological Responses
- Connective Tissue Growth Factor Research
Yinchuan First People's Hospital
2025
Huazhong University of Science and Technology
2017-2020
Tongji Hospital
2017-2020
Abstract Osteoarthritis (OA), an age‐related degenerative joint disease, is pathologically characterized by articular cartilage degeneration and synovial inflammation. Nephroblastoma overexpressed (NOV or CCN3), a matricellular protein, primary member of the CCN family (Cyr61, Ctgf, NOV) proteins involved in various inflammatory disorders. Previous studies reported that CCN3 might play therapeutic role OA. However, underlying mechanism remains unclear. In this study, we confirmed expression...
Osteoarthritis (OA) is a common degenerative joint disease in older adults. A number of previous studies have demonstrated that natural flavonoids can serve as promising therapeutic drugs for OA. Kaempferol, phytochemical ingredient mainly present various fruits, has exhibited its prominent anti‑inflammatory and antioxidant effects numerous diseases. However, whether Kaempferol ameliorates the deterioration arthritis remains to be elucidated. The aim study was investigate role on OA rat...
Objective This study aims to identify and quantify the high-risk factors for deep vein thrombosis (DVT) pulmonary embolism (PE) in elderly patients undergoing total knee replacement (TKA). Methods 621 who underwent TKA were divided into DVT/PE positive group ( N = 52) a negative 569). Result Statistically significant differences observed following factors: Caprini score (χ 2 11.385, p < .001), prevalence of chronic obstructive disease (COPD) 4.502, .034), history heart failure 4.326,...