A5068348950- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immune Cell Function and Interaction
- Obstructive Sleep Apnea Research
- Microplastics and Plastic Pollution
- Immunotherapy and Immune Responses
- Recycling and Waste Management Techniques
- Marine and fisheries research
- Advanced Neuroimaging Techniques and Applications
- Cancer Cells and Metastasis
- Functional Brain Connectivity Studies
- Tracheal and airway disorders
- Neuroscience of respiration and sleep
- Cleft Lip and Palate Research
- Toxic Organic Pollutants Impact
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Coral and Marine Ecosystems Studies
- T-cell and B-cell Immunology
- Microstructure and mechanical properties
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Cytokine Signaling Pathways and Interactions
- Coastal and Marine Management
- Mesenchymal stem cell research
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Shanghai Ninth People's Hospital
2014-2025
Shanghai Jiao Tong University
2015-2025
Wenzhou Medical University
2024-2025
Shandong University
2023-2025
Shandong Center for Disease Control and Prevention
2024-2025
Zhejiang Marine Fisheries Research Institute
2016-2025
Yueqing People's Hospital
2024-2025
National Clinical Research
2014-2025
Nanjing Agricultural University
2025
Myeloid-derived suppressor cells (MDSCs) represent heterogeneous immunosuppressive in multiple cancer types and display potent activity on T cells. We have shown the increased expression of IDO breast cancer. Because plays a pivotal role immune tolerance via suppressing cell function, aim this study was to investigate MDSCs its MDSC-mediated inhibition surveillance. The proportion with phenotype CD45(+)CD13(+)CD33(+)CD14(-)CD15(-) significantly primary tissues patients' peripheral blood....
Forkheadbox protein 3 (FOXP3), initially identified as a key transcription factor for regulatory T cells (Treg cells), was also expressed in many tumors including pancreatic ductal adenocarcinoma (PDAC). However, its role PDAC progression remains elusive. In this study, we utilized 120 tissues after radical resection to detect cancer-FOXP3 and Treg by immunohistochemistry evaluated clinical pathological features of these patients. Cancer-FOXP3 positively correlated with accumulation tumor...
The epithelial-mesenchymal transition (EMT) is a process through which epithelial cells trans-differentiate and acquire an aggressive mesenchymal phenotype. In tumor cells, EMT vital step of progression metastasis. Amid the increasing interest in EMT, only few studies focused on soluble mediators secreted by passing this phenotypic switch. review, we focus essential role interleukin-8 (IL-8) signaling for acquisition maintenance via direct indirect mechanisms. Besides autocrine loop between...
To cope with the limitations faced by autograft acquisitions particularly for multiple nerve injuries, artificial conduit has been introduced researchers as a substitute autologous graft easy specification and availability mass production. In order to best mimic structures components of nerve, great efforts have made improve designation conduits either from materials or fabrication techniques. Electrospinning is an versatile technique that recently used fabricate fibrous tissue-engineered...
We previously demonstrated that neurotensin (NTS) induces local inflammation and promotes tumor invasion in hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms are not clear. In this study, positive correlations between NTS interleukin (IL)-8 were identified at both mRNA protein levels 71 fresh HCC tissues 100 paraffin-embedded tissues. Furthermore, significant determined among co-expression of IL-8, infiltration inflammatory cells enhanced epithelial-mesenchymal...
// Shuli Liu 1, 2 , Dongxia Ye 1 Wenzheng Guo Wenwen Yu Yue He Jingzhou Hu Yanan Wang Ling Zhang Yueling Liao 2, 3 Hongyong Song Shuangshuang Zhong Dongliang Xu Huijing Yin Beibei Sun 4 Xiaofei Jingyi 5 Yadi Wu Binhua P. Zhou Zhiyuan Jiong Deng 3, Department of Oral and Maxillofacial–Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School Medicine, Shanghai, China Key Laboratory Cell Differentiation Apoptosis Chinese Minister Education, for Tumor Microenvironment...
Interleukin-6 (IL-6) has been reported to stimulate myeloid-derived suppressor cells (MDSCs) in multiple cancers, but the molecular events involved this process are not completely understood. We previously found that cancer-derived IL-6 induces T cell suppression of MDSCs vitro via activation STAT3/IDO signaling pathway. In study, we aimed elucidate underlying mechanisms. primary breast cancer tissues, was positively correlated with infiltration situ, which accompanied by more aggressive...
Abstract The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable clinical benefits non-small cell lung cancer (NSCLC), but mechanism responses remain unclear. We provide a rich resource 186,477 individual cells from 48 samples four treatment-naive and eight chemoimmunotherapy treated IIIA NSCLC patients (responders versus non-responders) by single-cell RNA-seq TCR-seq. observed synergistic increase B CD4...
Background: Radiodynamic therapy (RDT) is an emerging novel anti-cancer treatment based on the generation of cytotoxic reactive oxygen species (ROS) at lesion site following interaction between low-dose X-ray and a photosensitizer (PS) drug. For classical RDT, scintillator nanomaterials loaded with traditional PSs are generally involved to generate singlet (1O2). However, this scintillator-mediated strategy suffers from insufficient energy transfer efficiency hypoxic tumor microenvironment,...
Abstract Anti‐PD‐1 therapy has left an indelible mark in the field of non‐small‐cell lung cancer (NSCLC) treatment; however, its efficacy is limited clinical practice owing to differences degree effector T‐cell exhaustion. Casein kinase 2 (CK2) a protein that plays important role immunity. In this study, it aimed explore potential targeting CK2 and regulatory subunit CK2B prevent or reverse exhaustion, thereby enhancing anti‐PD‐1 NSCLC. found expression closely associated with exhaustion as...
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid that suppress T-cell activity in tumor microenvironment. However, the suppressive function MDSCs on B and its underlying mechanism remain unclear. Here, we show 4T1 breast cancer mice, significantly increased number MDSCs, parallel with splenic cells, accumulated when compared to normal mice. In presence surface molecules remolded, checkpoint-related such as PD-1 PD-L1 changing prominently. also emerge vital...
Regenerative medicine for bone tissue mainly depends on efficient recruitment of endogenous or transplanted stem cells to guide regeneration. Platelet-derived growth factor (PDGF) is a functional that has been widely used in regeneration and repair. However, the short half-life PDGF limits its efficacy, mechanism by which regulates cell-based still needs be elucidated. In this study, we established genetically modified PDGF-B-overexpressing marrow stromal (BMSCs) using lentiviral vector then...