Xiangyan Zhang
A5101903763- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- SARS-CoV-2 and COVID-19 Research
- Asthma and respiratory diseases
- Long-Term Effects of COVID-19
- Antifungal resistance and susceptibility
- Respiratory and Cough-Related Research
- Air Quality and Health Impacts
- Pediatric health and respiratory diseases
- Fungal Infections and Studies
- Toxoplasma gondii Research Studies
- Infectious Diseases and Mycology
- Respiratory Support and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Parasitic Infections and Diagnostics
- Dermatological and COVID-19 studies
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Inflammation biomarkers and pathways
Guizhou University
2018-2025
Guizhou Provincial People's Hospital
2016-2025
Affiliated Hospital of Qingdao University
2019-2024
Second Xiangya Hospital of Central South University
2024
Central South University
2024
Qingdao University
2015-2024
Weatherford College
2023
Jinhua Central Hospital
2023
Shanghai Medical College of Fudan University
2022
Zhongshan Hospital
2022
Previous studies on the pneumonia outbreak caused by 2019 novel coronavirus disease (COVID-19) were mainly based information from adult populations. Limited data are available for children with COVID-19, especially infected infants.We report a 55-day-old case COVID-19 confirmed in China and describe identification, diagnosis, clinical course, treatment of patient, including progression day 7 to 11 illness.This highlights that can also present multiple organ damage rapid changes.When managing...
Patients with mild or moderate chronic obstructive pulmonary disease (COPD) rarely receive medications, because they have few symptoms. We hypothesized that long-term use of tiotropium would improve lung function and ameliorate the decline in patients COPD.
BackgroundThe prevalence, epidemiological and clinical heterogeneities, impact profiles of individuals with preserved ratio impaired spirometry (PRISm), pre-COPD, young COPD, mild COPD in general Chinese population were not known yet.MethodsData obtained from the China Pulmonary Health study (2012–2015), a nationally representative cross-sectional survey that recruited 50,991 adults aged 20 years or older. Definitions four early disease status consistent latest publications Global Initiative...
Immunotherapy has rapidly become a primary treatment option for many lung cancer patients because of its success in treating this prevalent and deadly disease. However, the immunotherapy relies on overcoming immunosuppressive tumour microenvironment, making remodelling environment potential strategy therapy. Research suggests that Toll-like receptor (TLR) agonists can impede growth by promoting conversion tumour-associated macrophages into an M1-like state or enhancing dendritic cell...
Urinary matrix metalloproteinase-7 (uMMP-7) levels consistently reflect the activity of intrarenal Wnt/β-catenin, which is activated in AKI models. To test hypothesis that uMMP-7 a predictor for severe patients after cardiac surgery, we performed prospective, multicenter, two-stage cohort study 721 undergoing surgery. In stage 1, enrolled 323 children from three academic medical centers. 2, 398 adults at six We analyzed and other injury biomarkers during perioperative period. Severe was...
Abstract Objective Underlying mechanisms of non‐small cell lung cancer ( NSCLC ) development remain poorly understood. mi R ‐138 and 3‐phosphoinositide‐dependent protein kinase‐1 PDK1 have been reported to be involved in the genesis . The aim this study was investigate role human cells. Methods effect miR on proliferation A 549 cells first examined using 3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide assay. expression assessed by real‐time polymerase chain reaction further....
Interleukin6 (IL-6) is a key driver of hyperinflammation in COVID-19, and its level strongly correlates with disease progression. To investigate whether variability COVID-19 severity partially results from differential IL-6 expression, functional single-nucleotide polymorphisms (SNPs) were determined Chinese patients mild or severe illness. An Asian-common haplotype defined by promoter SNP rs1800796 intronic SNPs rs1524107 rs2066992 correlated severity. Homozygote carriers C-T-T variant at...
Rationale: It remains unknown whether long-term ozone exposure can impair lung function. Objectives: To investigate the associations between and adult function in China. Methods: Lung results diagnosis of small airway dysfunction (SAD) were collected from a cross-sectional study, China Pulmonary Health Study (N = 50,991). We used multivariable linear logistic regression models to examine with parameters SAD, respectively, adjusting for demographic characteristics, individual risk factors,...
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a deadly disease characterized by excessive collagen in the extracellular matrix (ECM) of lungs. Collagen primary protein component ECM. However, exact mechanisms underlying formation and deposition ECM under normal pathological conditions remain unclear. Previous studies showed that lysyl hydroxylase (LH) plays crucial role collagen. Minoxidil an FDA-approved anti-hypertensive agent inhibits LH reduces fibrosis. In this study, we...
We reported 20 cases of discharged COVID-19 patients whose RT-PCR test results showed 're-positive'. After finding 're-positive', these were admitted to hospital for the second time and followed up until end May 2020. recorded detailed treatment follow-up process, collected relevant data. The possible causes potential clinical significance this phenomenon are discussed.
Abstract Various studies demonstrated that bone morphogenetic proteins (BMPs) and their antagonists contribute to the development of cancers. Chordin‐like 2 (CHRDL2) is a member BMP antagonists. However, role its relative mechanism CHRDL2 in osteosarcoma remains unclear. In present study, we expression was significantly upregulated tissues cell lines compared with adjacent human normal osteoblast. Inhibition decreased proliferation colony formation cells vitro, as well migration invasion....
Chronic cough is a common complaint, but there are no population-based data on its burden in China. We determined the prevalence of chronic and impact health status adults stratified by sex, age diagnosis COPD or presence small airway dysfunction (SAD).A representative sample 57 779 Chinese aged 20 years older was recruited pulmonary function test measured. defined as lasting for >3 months each year. Quality life assessed 12-item Short Form Health Survey (SF-12), self-reported history...
Spirometry reference equations that are derived from a large, nationally representative general population warranted in China, and the impact of using prebronchodilator (pre-BD) post-BD spirometry values has yet to be assessed Chinese populations.
After early outbreaks in North America April 2009, the pandemic influenza A (H1N1) virus spread rapidly around world, and even some patients developed certain severe complications. We reported one case of hemophagocytic lymphohistiocytosis (HLH) induced by infection. 17-year-old girl had acute onset fever, dry cough, rhinorrhea, sore throat Her family members close friends also similar symptoms. Anti-infection treatment with penicillin was given after 8 days symptoms local hospital, her...