A5048938906- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- X-ray Diffraction in Crystallography
- Breast Lesions and Carcinomas
- Protein Tyrosine Phosphatases
- Crystallization and Solubility Studies
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Advanced Nanomaterials in Catalysis
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Sarcoma Diagnosis and Treatment
- MXene and MAX Phase Materials
- Lymphatic System and Diseases
- Body Contouring and Surgery
Second Xiangya Hospital of Central South University
2013-2024
Central South University
2013-2024
Kunming Medical University
2019
University of North Carolina at Chapel Hill
2007-2018
Tianjin Medical University
2018
Beijing Geriatric Hospital
2016
Beijing Hospital
2016
Wenzhou Medical University
2016
Highly sensitive and reliable detection of multiple myeloma remains a major challenge in liquid biopsy. Herein, for the first time, quantum dot-molecular beacon (QD-MB) functionalized MoS2 (QD-MB @MoS2) fluorescent probes were designed dual (MM)-related miRNA-155 miRNA-150. The results indicate that two can effectively detect miRNA-150 simultaneously with satisfactory recovery rates, limit detections (LODs) human serum are low to 7.19 fM 5.84 fM, respectively. These our method is most so far...
Although drug combination has proved to be an efficient strategy for clinic gastric cancer therapy, how further improve their bioavailability and reduce the side effects are still challenges due low solubility untargeted ability of drugs. Recently, newly emerging nanotechnology provided alternative constructing new delivery systems with high targeting solubility. In this study, a pH-responsive liposome (Liposome-PEO, LP) loaded apatinib (AP) cinobufagin (CS-1) was used combinational therapy...
Long non‑coding RNA (lncRNA) small nucleolar host gene 1 (SNHG1) was reported to be a critical regulator of tumorigenesis and is frequently deregulated in several cancer types. However, the exact mechanism by which SNHG1 contributes breast progression has not been fully elucidated. The identification molecular important for understanding development improving prognosis patients with this disease. In present study, increased expression levels were noted tumors following analysis...
The combination of chemo-photodynamic therapy has become a promising strategy for cancer by overcoming the limitations chemotherapy. However, hypoxic microenvironment, poor drug penetration, and metastatic malignant tumors still limited therapeutic efficacy this on triple-negative breast (TNBC). Hence, we developed combinational nanosystem efficient TNBC programming tumor microenvironment improving penetration ability. First, hybrid membrane (HM) camouflaged poly lactic-co-glycolic acid...
Objectives: As a complication of diabetes mellitus (DM), one the leading causes for death and disability DM patients is diabetic foot ulcers (DFUs). Epithelial to mesenchymal transition (EMT) plays critical role in wound healing DFUs. miR-203 specifically enriched keratinocytes has been shown target interleukin 8 (IL-8), which acts as an activator EMT process. In this study, we explored interaction between IL-8 DFU rat models human keratinocyte cells, underlying mechanism miR-203’s function...
Although combined photodynamic/photothermal therapy (PDT/PTT) has been used for cancer theranostics recently, their therapeutic efficacy compromised by the low O2 partial pressure and high concentration of GSH in tumor microenvironment (TME). Thus, construction intelligent TME-responsive nanocomplexes is a powerful strategy addressing above issues. In this study, MnO2-coated Prussian blue (PM NPs) were designed as suppliers depletion agents to reprogram TME. Subsequently, tumor-targeting...
Promoting angiogenesis is crucial for tissue repair. Adipose-derived mesenchymal stem cells (ADSCs) are endowed with the ability of paracrine secretion various angiogenic cytokines and differentiation potential into endothelium-like to directly participate in angiogenesis. ADSCs key seed promoting regenerative medicine engineering. This study aimed explore role mechanism C9orf106 (LINC02913) ADSCs.The microarray dataset GSE12884 was analyzed identify differentially expressed lncRNAs under...
The androgen receptor (AR) is a ligand-activated transcription factor of the male and female reproductive tracts whose activity modulated by coregulator binding. We recently identified melanoma antigen gene protein-11 (MAGE-11) MAGEA family that functions as an AR binding N-terminal FXXLF motif. Here we report MAGE-11 expressed in temporal fashion endometrium normally cycling women. Highest levels mRNA protein occur mid-secretory stage, coincident with window uterine receptivity to embryo...
The present study aimed to explore the effect of umbilical cord mesenchymal stem cells (UC-MSCs) on modulation T lymphocytes from system lupus erythematosus (SLE) patients and possible mechanism.A total 24 hospitalized SLE 28 healthy individuals were enrolled. sorted using Miltenyi magnetic beads. After addition recombinant human interleukin (IL)-2 CD3CD28 T-cell activator, loaded onto six-well plates pre-inoculated or not with UC-MSCs for 1 week culture. supernatants collected testing...
CYP2D6 is an important cytochrome P450 (P450) enzyme that metabolizes approximately 25% of therapeutic drugs. Its genetic polymorphisms may significantly influence the pharmacokinetics and pharmacodynamics clinically used Studying effects on drug metabolism can help reduce adverse reactions failure to some extent. This study aimed investigate role in nebivolol by evaluating effect 24 variants vitro. expressed insect cell systems were incubated with 0.1-80 μM for 30 minutes at 37°C reaction...
Abstract Background Suture knotting is the basis of surgical skills. In process skills learning, surrounding environment, especially light, will affect efficiency learning. This study investigated effect optical environment on learning stitching and Methods A total 44 medical students were randomly divided into four groups participated in suture different environments. During process, we assess objective pressure level by testing salivary amylase activity Likert scale structured clinical...
The role of PTPRT in breast cancer was not comprehensively explored and well analyzed. Our study searched available databases to analyze the clinical cancer. We found an antioncogene could be used distinguish different stages, age groups, molecular types, grades for might primary resistance biomarkers taxane, anthracycline, ixabepilone but acquired biomarkers. Higher expression levels were associated with longer overall survival recurrence-free survival. negatively Ki67 CDK4/6 positively...
Metabolic reprogramming is a hallmark of cancer. Several studies have shown that inactivation Krebs cycle enzymes, such as citrate synthase (CS) and fumarate hydratase (FH), facilitates aerobic glycolysis cancer progression. MAEL has been to play an oncogenic role in bladder, liver, colon, gastric cancers, but its breast metabolism still unknown. Here, we demonstrated promoted malignant behaviours cells. Mechanistically, interacted with CS/FH HSAP8 via domain HMG domain, respectively, then...
To study the effect of x-ray radiotherapy on vascular smooth muscle cells (VSMCs) and elucidate mechanisms in preventing neointimal hyperplasia prosthetic grafts.In model I, twelve mongrel dogs underwent revascularization with grafts half irradiation at 28 Gy. In II, human VSMCs (hVSMCs) were maintained divided into six groups to which external radiation was applied different doses: 0 Gy, 2 8 16 24 Gy 30 both models, specimens harvested examined by using morphological, immunological,...
The role of supraclavicular lymph node dissection (SCLND) in breast cancer patients with ipsilateral metastasis (ISLM) remains controversial. So far, there have been no effective imaging methods to precisely judge the feasibility SCLND and modes ISLM.We innovatively applied a three-dimensional (3D) reconstruction system assess preoperatively for 13 ISLM. Based on 3D intraoperative findings, we performed their lesion areas. Compared computed tomography or ultrasonography, found more nodes not...