Abstract Diabetic nephropathy (DN), characterized by the chronic loss of kidney function during diabetes, is a long‐term disease that affects millions populations. However, etiology DN remains unclear. cell model was established treating HK‐2 cells with high glucose (HG) in vitro. Expression metastasis‐associated lung adenocarcinoma transcript‐1 (MALAT1), miR‐30c, nucleotide binding and oligomerization domain‐like receptor protein 3 (NLRP3), caspase‐1, IL‐1β, IL‐18 treated were tested...

Aim: To evaluate the genetic associations of visceral adipose tissue (VAT) mass with metabolic risk factors and cardiovascular disease (CVD) endpoints to construct a network analysis about underlying mechanism using Mendelian randomization (MR) analysis. Methods Results: Using summary statistics from genome-wide association studies (GWAS), we conducted two-sample MR assess effects VAT on 10 53 CVD endpoints. Genetically predicted was associated factors, including triglyceride (odds ratio,...

Background The efficacy of tonsillectomy in immunoglobulin A nephropathy (IgAN) remains controversial. aim the study was to conduct a randomized controlled trial evaluate effect patients with IgAN. Methods We randomly selected 98 biopsy-proven IgA and allocated receive combined drug therapy (Group A) or alone B). participating were entered into 4-year single-center study. Remission relapse rate calculated for hematuria proteinuria using Kaplan–Meier method. Results No differences found...

Observational studies have linked exposure to fine (PM2.5) and coarse (PM10) particulate matter air pollution with adverse COVID-19 outcomes, including higher incidence mortality. However, some questioned the effect of on susceptibility, raising questions about causal nature these associations. To address this, a less biased method like Mendelian randomization (MR) is utilized, which employs genetic variants as instrumental variables infer relationships in observational data.

New Findings What is the central question of this study? Diabetic nephropathy (DN) a severe complication diabetes correlated with higher mortality rate in diabetic patients. Renal tubular injury participates pathogenesis DN. We aimed to uncover biological function NEAT1–miR‐150‐5p–DRP1 axis an vitro model DN and elaborate potential mechanisms. main finding its importance? NEAT1 facilitated high glucose‐induced damage HK‐2 cells by reducing mitophagy via miR‐150‐5p–DRP1 axis, which sheds...

Postmenopausal osteoporosis (PMOP) brings a lot of inconvenience to patients and serious economic burden society. The osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) plays vital role in the process PMOP treatment. However, functional mechanism remains unclear. In this study, GATA4, MALAT1 KHSRP were downregulated tissues patients, while NEDD4 was overexpressed. Through experiments, GATA4 overexpression strikingly accelerated BMSCs promoted formation vitro vivo, these...

Abstract This paper investigates China's coal price volatility spreaders (CPVSs) from the supply side to locate source since may destabilize many downstream products' prices or even bring uncertainties macroeconomic output. Especially in carbon neutrality context, market is being reconstructed and responding imbalances between demand; identifying CPVSs helps alleviate rising instability prevent energy-induced system risk. To achieve this objective, we explore causalities among 938 weekly...

Hyperuricemia (HUA) is strongly associated with abnormal glucose metabolism and insulin resistance (IR). However, the precise molecular mechanism of HUA-induced IR still unclear. Retinol binding protein 4 (RBP4) has been shown to induce in type 2 diabetes mellitus. This study was designed clarify relationship between RBP4 its potential mechanisms. Patients HUA were collected detect levels plasma clinical biochemical indicators. Rats fed 10% high yeast oteracil potassium (300 mg/kg) via...

Objective: This study investigates the preventive and therapeutic effects of medical radiation protection spray (Bergmann) compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery. Methods: Ninety with who received postoperative between July 2018 2021 were randomly divided into Bergmann treatment (experimental) group (control) group, 45 each group. Radiodermatitis severity was assessed using RTOG radiodermatitis grading standards. Results: The...

IgA nephropathy (IgAN) is the most common primary glomerular disease. The characteristic pathology involves immune complexes formed by deposition of IgA1 and underglycosylated aggregates in mesangial area, which may be accompanied IgG and/or IgM complement components. However, molecular mechanisms IgAN remain unclear. In present study, microarray analysis showed that expression microRNA-630 (miR-630) was significantly reduced palatal tonsils from patients compared with chronic tonsillitis....

Microglia cells are the main mediators of neuroinflammation. Activation microglia often aggravates pathological process various neurological diseases. Natural chemicals have unique advantages in inhibiting microglia-mediated neuroinflammation and improving neuronal function. Here, we examined effects asperosaponin VI (ASA VI) on LPS-activated primary microglia. were isolated from mice pretreated with different doses ASA VI, following lipopolysaccharide (LPS) administration. inflammatory...

Objective. To investigate the influence of in vitro vibratory stimulation human tonsillar mononuclear cells (TMCs). Methods. Fourteen IgA nephropathy (IgAN) patients with chronic tonsillitis (CT) and 12 CT no renal pathology were enrolled. Group A TMCs collected after 24 hours culture used to determine baseline levels. groups B, C, D, E, F exposed (60 Hz) for 0 (as control group), 1, 3, 5, 10 minutes, respectively. Results. Baseline concentrations B-cell-activation factor (BAFF) IgA1, BAFF...

Abstract Background Suture knotting is the basis of surgical skills. In process skills learning, surrounding environment, especially light, will affect efficiency learning. This study investigated effect optical environment on learning stitching and Methods A total 44 medical students were randomly divided into four groups participated in suture different environments. During process, we assess objective pressure level by testing salivary amylase activity Likert scale structured clinical...

The clinical advantages of painless colonoscopy can reduce the fear and discomfort patients increase detection rate diseases. Propofol has characteristics fast effect short action time. It is a common choice for endoscopic sedation anesthetics. However, propofol cause severe respiratory circulatory depression. Therefore, it important to find way dose propofol.To explore wrist-ankle acupuncture on during colonoscopy.Two hundred who were going receive selective in Hebei Hospital Traditional...

Low social-economic status is associated with atrial fibrillation (AF), but the extent of any causative effect unclear. In present study, we evaluated causal role educational attainment (EA) on AF using Mendelian randomization (MR) analysis. Results from traditional single-variable MR indicated a modest EA AF. Sensitivity analyses different methods yielded consistent results. Multi-variable and mediation analysis revealed that protective higher was partially mediated by reducing...

Aims: This study aimed to evaluate the extent of apoptosis tonsillar mononuclear cells (TMCs) derived from patients with IgA nephropathy (IgAN) and effects triptolide (TP) on these TMCs. Methods: TMCs were isolated tissues IgAN or chronic tonsillitis (control group). Rates measured by annexin V-fluorescein isocyanate (FITC)/propidium iodide (PI)-labeled flow cytometry (FCM). Expression levels Bcl-2 family proteins quantified immunohistochemistry fixed sections Western blot analyzes lysates....

Cross-regional air pollutant spillovers aggravate pollution in China. To mitigate pollution, identifying and monitoring spreaders (APS) is a vital strategy that helps locate the source of guides Joint Prevention Control Air Pollution. In this paper, we define an APS as city with high spillover impact (CHSI) propose transfer entropy network to investigate from multi-timescale analysis perspective. Taking time series PM 2.5 concentration 358 Chinese cities 1 January 2015 31 December 2020...

To evaluate the clinical efficacy of a bioabsorbable dressing in combination with antibacterial spray treating third-degree burns.Patients burns our hospital from February 2019 to 2020 were enrolled and divided into an experimental group control group. In all patients, two wound repair surgeries performed. During first surgery, (PELNAC, Gunze Medical Equipment (Shenzhen) Co. Ltd., China) was used for treatment. second autologous split-thickness skin graft For patients group, dressings...

Most hospitalized preterm infants experience difficulties in transitioning from tube feeding to full oral feeding. Interventions promote the neonatal intensive care unit (NICU) are limited pacifier use or bottle-feeding exercises. Skin contact has been shown be beneficial start and maintain lactation provide with opportunity suck on mother's breast, which may further development of infant's suckling patterns. The objective this study is compare evaluate effects skin combined breastfeeding...