A5028600976- Pharmacogenetics and Drug Metabolism
- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Drug Transport and Resistance Mechanisms
- Trace Elements in Health
- Lipoproteins and Cardiovascular Health
- Heavy metals in environment
- Pharmacological Effects and Toxicity Studies
- Climate Change and Health Impacts
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Air Quality Monitoring and Forecasting
- Esophageal Cancer Research and Treatment
- Analytical Methods in Pharmaceuticals
- Blood Pressure and Hypertension Studies
- Receptor Mechanisms and Signaling
- Chinese history and philosophy
- Eicosanoids and Hypertension Pharmacology
- Pharmaceutical Economics and Policy
- Hormonal Regulation and Hypertension
- Vitamin D Research Studies
- Computational Drug Discovery Methods
- Higher Education and Teaching Methods
- Renal Diseases and Glomerulopathies
- Systemic Lupus Erythematosus Research
Third Xiangya Hospital
2016-2025
Central South University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Sun Yat-sen University
2024-2025
Chinese Academy of Sciences
2025
Second Affiliated Hospital of Fujian Medical University
2018-2025
Fujian Medical University
2018-2025
Ningbo Institute of Industrial Technology
2025
Air Force General Hospital PLA
2024
Hunan Provincial Center for Disease Control and Prevention
2024
Tacrolimus is used clinically for the long-term treatment of antirejection transplanted organs in liver and kidney transplant recipients, although dose optimization poorly managed. The aim this study was to examine association between tacrolimus pharmacokinetic variability CYP3A4 CYP3A5 genotypes by a population analysis based on routine drug monitoring data adult renal recipients.Trough concentrations were obtained from 161 recipients after transplantation. carried out using nonlinear...
Our previous research revealed that an increase in PCSK9 is linked to aggravated inflammation the kidneys of mice affected by a high-fat diet and streptozotocin (HFD/STZ) or HGPA-induced HK-2 cells. Furthermore, cGAS/STING pathway has been reported be involved diabetic nephropathy (DN). Therefore, this study, we aimed examine correlation between proinflammatory effect DN. We used mAbs inhibit vivo siRNA vitro measured inflammatory phenotype HFD/STZ-treated cells, observed decreased blood...
Graphical Abstract Main steps used to predict PK and PD outcomes of the compounds. (Step 1) Use different AI related simulations compound’s ADME physiochemical properties. 2) Predict using PBPK model. 3) models are how changes in drug concentrations affect gastric acid secretion pH. E/E0 is relative activity H + /K ATPase by drug; k sec rate constants for intra-gastric concentration; out elimination constant obs observed concentration ; I (Inhibition) current antisecretory effect (or pH...
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent pathology characterized by hepatic steatosis and commonly accompanied systematic inflammation metabolic disorder. Despite accumulating number of studies, no pharmacological strategy available to treat this condition in the clinic. In study, we applied extensive gain- loss-of-function approaches identify key immune factor leukocyte immunoglobulin-like receptor B4 (LILRB4) as a negative regulator NAFLD. The...
The influence of chronic arsenic exposure on cognitive impairment has been explored broadly by previous studies. However, most them focused mainly children rather than adults. In addition, in China, studies this field are not sufficient. To illustrate how long-term affects function, we designed a cross-sectional study involving 1556 adults.All came from three locations around the Realgar Plant. function participants was evaluated using Chinese version Mini-mental state Examination (MMSE)....
Meniscus tear is a common problem in sports trauma, and its imaging diagnosis mainly relies on MRI. To improve the diagnostic accuracy efficiency, deep learning model was employed this study identification efficiency evaluated.Standard knee MRI images from 924 individual patients were used to complete training, validation testing processes. Mask regional convolutional neural network (R-CNN) build structure, ResNet50 adopted develop backbone network. The trained validated with dataset...
Increasing evidence from experimental research suggests that exposure to microcystins (MCs) may induce lipid metabolism disorder. However, population-based epidemiological studies of the association between MCs and risk dyslipidemia are lacking. Therefore, we conducted a cross-sectional study involving 720 participants in Hunan Province, China, evaluated effects on blood lipids. After adjusting related metals, used binary logistic regression multiple linear models examine associations among...
The aim of this study was to assess the correlation between blood lead levels and both serum uric acid hyperuricemia in adult residents living within an area China with pollution. We conducted a cross-sectional analysis 2120 subjects (1180 whom were male) ages 20 75 years who had undergone health examinations at Centers for Disease Control Prevention (CDC) lead-polluted June 2013 September 2014. Blood positively correlated males (r = 0.095, p 0.001) females 0.134, < 0.001). Multivariate...
Associations between most single metals and children's intelligence quotient (IQ) scores have been evaluated in previous studies. However, associations multi-metal exposures IQ not analyzed.To assess the joint effects of lead (Pb), manganese (Mn), antimony (Sb), tin (Sn) titanium (Ti) co-exposure on scores.A prospective cohort study was conducted Shimen Huayuan, Hunan Province, China. Urine levels were measured by inductively coupled plasma mass spectrometry (ICP-MS) at baseline. Children's...
Pruritus is identified as an adverse drug reaction to arsenic trioxide, but the association of exposure with pruritus has not been investigated.A cross-sectional study was conducted in Shimen, China. A Mendelian randomization analysis confirm causal relationship between genetically predicted percentages monomethylated (MMA%) and dimethylated (DMA%) urine chronic UK Biobank. case-control then determine biomarker for pruritus. Arsenite-treated mice were used biomarker, von Frey test induce...
Fine particulate matter (PM2.5)-related health issues have received increasing attention as a worldwide public problem, and PM2.5-related chronic kidney disease (CKD) has been emerging over the years. Limited research focused on mechanism of PM2.5-induced disease. To investigate impact PM2.5 its potential mechanism, we generated PM2.5-exposed C57BL/6 mouse model by using Shanghai Meteorological Environment Animal Exposure System (Shanghai-METAS) for 12 weeks, urine, blood tissues were...