A5004327943- Antibiotic Resistance in Bacteria
- Bone Metabolism and Diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Bone health and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Enterobacteriaceae and Cronobacter Research
- Salmonella and Campylobacter epidemiology
- Bacteriophages and microbial interactions
- Escherichia coli research studies
- Peptidase Inhibition and Analysis
- Bacterial Genetics and Biotechnology
- Vibrio bacteria research studies
- Mesenchymal stem cell research
- Dental materials and restorations
- MicroRNA in disease regulation
- Antimicrobial Peptides and Activities
- S100 Proteins and Annexins
- Bone and Dental Protein Studies
- Tuberculosis Research and Epidemiology
- Radiopharmaceutical Chemistry and Applications
- Wnt/β-catenin signaling in development and cancer
- Bone health and osteoporosis research
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Bacterial Identification and Susceptibility Testing
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2016-2025
Third Xiangya Hospital
2023-2025
Central South University
2023-2025
Hunan Provincial Center for Disease Control and Prevention
2025
Hainan University
2025
Stomatology Hospital
2013-2024
Hospital of Stomatology, Sun Yat-sen University
2014-2024
Sun Yat-sen University
2014-2024
Institute of Microbiology
2020
Community-onset bloodstream infections (COBSIs) caused by ESBL-producing Escherichia coli (ESBL-EC) and Klebsiella pneumoniae (ESBL-KP) are increasing globally. This study aimed to investigate the epidemiology risk factors of ESBL-EC ESBL-KP in COBSIs China.A prospective, multicentre was performed 28 tertiary hospitals from September 2013 November 2014. All isolates ESBLs were microbiologically characterized. A statistical analysis using binary logistic regression. The trial registered with...
Enterobacter spp. are members of the 'ESKAPE' group pathogens, which recognised as leading cause multidrug-resistant (MDR) hospital-acquired infections. Colistin is usually regarded a last-line therapeutic option for MDR Gram-negative bacilli However, colistin-resistant have emerged in last decade. Here we investigated prevalence colistin resistance and mcr genes clinical origin between 2011 2020 tertiary hospital China. rates ranged 17.1% 34.5%, with an overall 22.2% (190/854). No mcr-1 to...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a major nosocomial infectious pathogen with rapidly increasing prevalence. The genomic epidemiological characteristics of CRKP nationwide, especially the evolving trends within predominant clones, should be evaluated clearly.
Cancer poses a significant threat to human health worldwide, and many therapies have been used for its palliative curative treatments. Vincristine has extensively in chemotherapy. However, there are two major challenges concerning applications various tumors: (1) Vincristine's antitumor mechanism is cell-cycle-specific, the duration of exposure tumor cells can significantly affect activity (2) widely bio-distributed be rapidly eliminated. One solution these encapsulation vincristine into...
ObjectivesCommunity onset urinary tract infections (COUTIs) drew attention recently owing to their increased prevalence and associations with resistant pathogens. The study is aimed at investigating the etiology of COUTIs as well related risk factors extended-spectrum β-lactamase (ESBL) in China.MethodsThe prospective was performed nineteen hospitals during November 1, 2017 August 31, 2019. Non-duplicated isolates from were included. ESBL phenotypic confirmation test whole genomes sequenced...
The emergence of carbapenem-resistant Enterobacter cloacae complex (CR-ECC) has posed significant global challenges to the clinical treatment healthcare-associated infections. This study reports clonal outbreak NDM-1-producing hormaechei (E. hormaechei) with coexistence tmexCD2-toprJ2 and mcr-9 in China.During (January 2018 - December 2021), 15 non-repetitive multidrug-resistant E. strains were obtained from 13 patients a tertiary hospital. Antimicrobial susceptibility testing, plasmid...
Colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses health challenges. To investigate the prevalence and molecular characteristics of colistin-resistant CRKP, 708 isolates were consecutively collected from 28 tertiary hospitals 2018 to 2019 China, 14 CRKP identified. Two-component systems (TCSs) related colistin (PmrA/B, PhoP/Q, CrrA/B), negative regulator mgrB gene mcr genes, analyzed using genomic sequencing. The relative expression TCS genes along with their...
To investigate the epidemiology of ST20 carbapenem-resistant
This study investigates relationships between EMT and bone invasion by OSCC. Three OSCC cell lines, SCC25, HN5, Tca8113 were artificially induced to display adding 5 ng/mL of TGF-β1 culture media for 1-3 days. Cell morphology phenotypic changes was examined immunocytochemical staining CK VIM. markers, cell-invasion factors, osteoclast-related molecules analysed at mRNA, gelatine protein levels real-time PCR, zymography Western blotting respectively. Mature osteoclasts differentiated from...
BackgroundAlthough the emergence of plasmid-mediated colistin resistance gene, mcr-1, caused global concern, little is known about its clinical implications and transmission characteristics over time. We aimed to investigate relevance infection with mcr-1-positive Escherichia coli isolates long-term plasmid dynamics.MethodsWe did a multicentre case-control study molecular epidemiological survey E infections. from four hospitals in China 2008 2017 were collected screened for mcr-1 by PCR...
Abstract Osteoclasts and foreign body giant cells (FBGCs) are both derived from the fusion of macropahges. These seen in close proximity during reactions, therefore it was assumed that they might interact with each other. The aim to identify important genes expressed by osteoclasts FBGCs which can be used understand peri‐implantitis predict relationship these reactions. Bone marrow macrophages (BMM) were treated receptor activator nuclear factor kappa B ligand (RANKL) produce osteoclasts....
A plasmid-mediated colistin resistance gene, mcr-1, has been reported worldwide and caused concern regarding a major therapeutic challenge. Alarmingly, mcr-1 spread into clinical carbapenem-resistant Enterobacteriaceae isolates, resulting in extensively drug-resistant even pan isolates that can cause untreatable infections. In this study, we report isolation of an Escherichia coli strain EC1188 coproduces NDM-16 MCR-1 from urine sample taken patient with craniocerebral injury.E. was...
Carbapenem-resistant Klebsiella pneumoniae (CRKP) infection poses a great threat to public health worldwide, and KPC-2-producing strains are the main factors responsible for resistance carbapenems in China. Ceftazidime/avibactam (CZA) is novel β-lactam/β-lactamase inhibitor combination with good activity against KPC-2 carbapenemase becoming most important option treating KPC-producing CRKP infection. Here, we report emergence of variant, designated KPC-74, produced by K. strain KP55, that...
OXA-232 is a variant of OXA-48 carbapenemase, which has been increasingly reported in nosocomial outbreaks ICUs. However, the OXA-232-CRKP transmission relationship between environment and patients ICUs was still not clear.
Fine particulate matter (PM2.5)-related health issues have received increasing attention as a worldwide public problem, and PM2.5-related chronic kidney disease (CKD) has been emerging over the years. Limited research focused on mechanism of PM2.5-induced disease. To investigate impact PM2.5 its potential mechanism, we generated PM2.5-exposed C57BL/6 mouse model by using Shanghai Meteorological Environment Animal Exposure System (Shanghai-METAS) for 12 weeks, urine, blood tissues were...
Diabetic nephropathy (DN) is a serious complication of diabetes, and inflammation plays crucial role. Sirtuin 2 (SIRT2), NAD+-dependent deacetylase, which involved in the regulation cell metabolism, proliferation longevity through deacetylation. Our previous research showed positive correlation between urinary SIRT2 levels renal injury markers DN patients. Therefore, this study explored specific role its regulatory relationship with inflammatory response. Increased expression was observed...
Abstract BACKGROUND Prenylated flavonoids are widely distributed in plants, including fruits and vegetables the Moraceae Fabaceae families. These chemicals potential functional food ingredients owing to their attractive biological activities. However, natural prenylated rare, which limits application. RESULTS Here, we reported prenylation of apigenin genistein catalyzed by DMATS1, a dimethylallyl‐ l ‐tryptophan synthase from Fusarium fujikuroi . High‐performance liquid chromatography–tandem...