A5101680339- Periodontal Regeneration and Treatments
- Oral microbiology and periodontitis research
- Bone Tissue Engineering Materials
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Oral Health Pathology and Treatment
- Electrospun Nanofibers in Biomedical Applications
- Conducting polymers and applications
- Perovskite Materials and Applications
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Dental Implant Techniques and Outcomes
- Metal and Thin Film Mechanics
- Advanced biosensing and bioanalysis techniques
- Quantum Dots Synthesis And Properties
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Oral and gingival health research
- Inflammasome and immune disorders
- Advanced Glycation End Products research
- Connective tissue disorders research
- Dental Radiography and Imaging
- Proteoglycans and glycosaminoglycans research
Air Force Medical University
2016-2025
National Clinical Research
2017-2024
Xi’an University of Posts and Telecommunications
2023
Stomatology Hospital
2016-2022
Zhejiang Lab
2022
Zhejiang University
2022
Southwest Petroleum University
2018-2020
Nanjing Normal University
2017-2018
Chinese Academy of Fishery Sciences
2012-2014
Jinan Maternity And Care Hospital
2011
Fabricating nanostructured surface topography represents the mainstream approach to induce osteogenesis for next-generation bone implant. In past, implant was designed minimize host repulsive reactions in order acquire biocompatibility. However, increasing reports indicate that absence of an appropriate immune response cannot adequate osseointegration after implantation vivo.We prepared different topographies on titanium (Ti) specimens by grinding, etching and anodizing, they were marked as...
Abstract Background Periodontitis is caused by the imbalance of anti‐bacteria immune response and excessive inflammation whereas macrophages play an important role in inflammation. Thus, it critical for finding efficient anti‐inflammatory strategies to alleviate periodontal prevent bone destruction. Apoptosis mesenchymal stem cells (MSCs) exerts silencing effects, however, using these effects develop remains unknown. In our study, we extracted apoptotic extracellular vesicles (ApoEVs) from...
A new nodavirus, named covert mortality nodavirus (CMNV), is associated with disease of shrimp which has caused serious loss in China since 2009. Histopathological examination suffering the revealed coagulative necrosis striated muscle similar to typical histopathology features infectious myonecrosis virus (IMNV), Penaeus vannamei (PvNV) and Macrobrachium rosenbergii (MrNV). However, this tested negative for IMNV, MrNV PvNV by reverse transcription (RT)-PCR. Additionally, eosinophilic...
Abstract Objective Autophagy, which provides a mechanism for turnover cellular organelles and proteins through lysosome‐dependent degradation pathway, has been related to the pathogenesis of inflammatory disorders other diseases. Therefore, aim this research was study role autophagy in periodontal ligament stem cells ( PDLSC s) provide new strategy treatment or prevention periodontitis. Methods We used immunohistochemistry detect LC 3 expression PDL ) tissues from patients with (n = 20)...
Ti-GO-Ag nanocomposite: the effect of content level on antimicrobial activity and cytotoxicity Jianfeng Jin,1,2 Li Zhang,3 Mengqi Shi,3 Yumei Qintao Wang11State Key Laboratory Military Stomatology National Clinical Research Center for Oral Diseases Shaanxi Engineering Dental Materials Advanced Manufacture, Department Periodontology, School Stomatology, The Fourth Medical University, Xi’an, 2Department General Dentistry, Kunming Municipal Hospital, Kunming, 3State Prosthodontics,...
Angiogenesis alteration in tooth support tissue plays an essential role periodontitis. Mesenchymal stem cells (MSCs) can affect vessel formation by endothelial (ECs) through paracrine function. Autophagy is reported to be closely related cell secretion. Here we investigated the angiogenesis-promoting ability of MSCs that reside periodontal ligament (known as cells, PDLSCs) under inflammatory conditions order explore mechanism angiogenesis periodontitis.PDLSCs were isolated from healthy and...
Abstract Severe muscle injury is hard to heal and always results in a poor prognosis. Recent studies found that extracellular vesicle-based therapy has promising prospects for regeneration medicine, however, whether vesicles have therapeutic effects on severe still unknown. Herein, we extracted apoptotic derived from mesenchymal stem cells (MSCs-ApoEVs) treat cardiotoxin induced tibialis anterior (TA) MSCs-ApoEVs promoted muscles increased the proportion of multinucleated cells. Besides...
The periodontitis is one of the most prevalent diseases with alveolar resorption in adult people and main cause tooth loss. To investigate possibility for protecting loss bone periodontal diseases, a RNAi-based therapeutic strategy applied silencing RANK signaling using thermosensitive chitosan hydrogel as siRNA reservoir vector. was formed from solution (PH = 7.2, at 4°C) 37°C within 8 minutes. degradation rates were ~50% 5% (W remaining/W beginning) presence absence lysozyme, respectively,...
Abstract Macrophage polarization plays an important role in the progression of inflammation. Exosomes derived from stem cells are promising candidates for macrophage immunoregulation. However, how exosomes periodontal ligament (PDLSCs) inflammatory environment influence has yet to be fully elucidated. In this study, PDLSCs were found downregulate M2 at mRNA and protein levels a Transwell coculture system THP-1-derived M0 macrophages. Furthermore, PDLSC-derived shifted macrophages toward M1...
Background: Human periodontal ligament stem cells (PDLSCs) display efficient osteogenic differentiation capacity but fail to rescue bone breakdown associated with periodontitis. Endoplasmic reticulum (ER) stress and the unfolded protein response have recently been linked inflammation differentiation. Therefore, role of double‐stranded RNA‐activated kinase (PKR)‐like ER (PERK) pathway in impaired ability PDLSCs treated tumor necrosis factor (TNF)‐α was investigated. Methods: were isolated...
The dark sleeper (Odontobutis potamophila) is an important commercial fish species which shows a sexually dimorphic growth pattern. However, the lack of sex transcriptomic data hindering further research and genetically selective breeding sleeper. In this study, integrated analysis mRNA miRNA was performed on gonad tissue to elucidate molecular mechanisms determination differentiation in A total 143 differentially expressed miRNAs 16,540 genes were identified. Of these, 8103 mRNAs 75...
As a superstars of photovoltaic devices, organic–inorganic hybrid perovskite solar cells (PSCs) have garnered plenty interest due to their superior character. However, many defects, such as carrier recombination, inferior stability, poor interface contact, prevented further development. Here, we demonstrate novel approach engineering form compact layer with decreased defects on SnO2 film by adding tris(pentafluorophenyl)boron (TPFPB) an interfacial modification layer, which validly improves...
The comprehensive recognition of communications between bone marrow mesenchymal stem cells (bm-MSCs) and macrophages in the peri-implant microenvironment is crucial for implantation prognosis. Our previous studies have clarified indirect influence Ti surface topography osteogenic differentiation bm-MSCs through modulating macrophage polarization. However, cell communication commutative multi-directional. As immune regulatory properties MSCs become increasingly prominent, whether could also...