A5003433490- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Vitamin C and Antioxidants Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Bioactive Compounds and Antitumor Agents
- Phytochemical Studies and Bioactivities
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Free Radicals and Antioxidants
- Phytochemistry and Bioactive Compounds
- Bioactive natural compounds
- Tannin, Tannase and Anticancer Activities
- Pharmacological Effects of Natural Compounds
- Retinoids in leukemia and cellular processes
- Click Chemistry and Applications
- Enzyme function and inhibition
- Phytochemistry and Biological Activities
- Bladder and Urothelial Cancer Treatments
- Synthesis and Reactions of Organic Compounds
- RNA Interference and Gene Delivery
- Synthesis and Reactivity of Heterocycles
Meikai University
2016-2025
Saitama Medical University
2014-2025
Social Insurance Saitama Chuo Hospital
2025
Hoshi University
2025
Institute of Pharmacology
2020
Division of Chemistry
2020
Shanghai Ninth People's Hospital
2018-2019
Tokyo University of Pharmacy and Life Sciences
2002-2015
Josai University
2002-2015
University of Michigan
2012
Mouse myeloid leukemia cells can be induced to differentiate into macrophages in vitro by 1 alpha,25-dihydroxyvitamin D3, the active form of vitamin D3. The minimal concentration D3 induce cell differentiation was 0.12 nM. degree various markers 12 nM nearly equivalent that microM dexamethasone, most potent known stimulator. Among several phagocytic activity within 24 hr, and this followed induction lysozyme locomotive activities. Similar changes were also 0.01-1 alpha-hydroxyvitamin...
Recently, the SARS-CoV-2 induced disease COVID-19 has spread all over world. Nearly 20% of patients have severe or critical conditions. exploits ACE2 for host cell entry. plays an essential role in renin–angiotensin–aldosterone system (RAAS), which regulates blood pressure and fluid balance. also protects organs from inflammatory injuries intestinal functions. can be shed by two proteases, ADAM17 TMPRSS2. TMPRSS2-cleaved allows entry, whereas ADAM17-cleaved offers protection to organs....
The use of nanoparticles (NPs) has become a significant area research in Dentistry. Objective aim this study was to investigate the physical, antibacterial activity and bond strength properties conventional base, core build restorative glass ionomer cement (GIC) compared GIC supplemented with titanium dioxide (TiO2) nanopowder at 3% 5% (w/w). Material Methods Vickers microhardness estimated diamond indenter. Compressive flexural strengths were analyzed universal testing machine. Specimens...
A series of new 4-(3-(4-substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides (7-12) was synthesized starting from 2-(4-substitutedbenzylidene)-2,3-dihydro-1H-inden-1-one (1-6) and 4-hydrazinobenzenesulfonamide. The substituted benzaldehydes which the key intermediate prepared by introducing 2- or 4-substituents such as fluorine, hydroxy, methoxy, 3,4,5-trimethoxy moieties. compounds were tested for their cytotoxicity, tumor-specificity potential carbonic...
Medication-related osteonecrosis of the jaw (MRONJ) is a rare but potentially severe condition that significantly affects quality life patients with cancer. This study evaluated MRONJ in cancer treated zoledronic acid (ZOA) and denosumab (Dmab). The survey investigated who were diagnosed at Department Oral Maxillofacial Surgery after receiving either ZOA or Dmab Saitama Medical Center, University, between April 1, 2022, March 31, 2023. Of 252 patients, 27 users 225 users. was not observed...
A new pyranoflavanone, sanggenol L (1), a Diels−Alder type adduct regarded as cycloaddition product of dehydrogeranylflavanone and prenylchalcone, M (2), along with four 2-arylbenzofurans isoprenoid units, mulberrofurans W−Z (3−6), were isolated together 10 known flavonoids from Chinese Morus mongolica. The structures these novel compounds elucidated by spectroscopic methods. All flavanones investigated here showed higher cytotoxicity against human oral tumor cell lines (HSC-2 HSG) than...
Three new flavonoid glycosides, together with 15 known flavonoids, have been isolated from the leaves of Eriobotrya japonica, and characterized as (2S)- (2R)-naringenin 8-C-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranosides, cinchonain Id 7-O-beta-D-glucopyranoside, respectively, based on spectral analyses including two dimensional (2D) NMR techniques. Higher proanthocyanidin fraction in water-soluble portion extract was a procyanidin oligomer mixture mainly composed undecameric...
In the search for anti-viral and antitumor substances from natural resources, antiviral activities of licorice root extract purified ingredients were investigated.Viability cells was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Antiviral activity quantified selectivity index, defined as ratio 50% cytotoxic concentration (CC50) to effective against human immunodeficiency virus (HIV) or herpes simplex (HSV)-infected (EC50). The tumor specificity calculated...