A5058006275- Drug Transport and Resistance Mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Wound Healing and Treatments
- Bioactive Natural Diterpenoids Research
- Bioactive Compounds and Antitumor Agents
- Antibiotic Resistance in Bacteria
- Burn Injury Management and Outcomes
- Natural product bioactivities and synthesis
- HIV/AIDS drug development and treatment
- Reconstructive Surgery and Microvascular Techniques
- Synthesis and Characterization of Heterocyclic Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis and biological activity
- Synthesis and Reactivity of Heterocycles
- Surgical Sutures and Adhesives
- Synthesis and Biological Evaluation
- Plant-based Medicinal Research
- DNA and Nucleic Acid Chemistry
- Antibiotics Pharmacokinetics and Efficacy
- Quinazolinone synthesis and applications
- Surgical site infection prevention
- Metal complexes synthesis and properties
- Reconstructive Facial Surgery Techniques
- thermodynamics and calorimetric analyses
Wake Forest University
2015-2025
University School
2023-2025
Forest Institute
2019-2023
Atrium Health Wake Forest Baptist
2002-2023
University of Szeged
2013-2022
United States Naval Research Laboratory
2005-2022
Naval Research Laboratory Information Technology Division
2011-2022
Louisiana State University
2019-2021
University Medical Center New Orleans
2021
Medical University of South Carolina
2021
Lower-extremity wounds with exposed tendon, bone, or orthopedic hardware present a difficult treatment challenge. In this series of patients, subatmospheric pressure therapy was applied to such lower-extremity wounds. Seventy-five patients wounds, most which were the result trauma, selected for study. Dressings made sterile open-cell foam embedded fenestrated tubing contoured wound size and placed into wound. The site covered an adhesive plastic sheet. sheet beneath any external fixation...
Unlike conventional reconstruction, facial transplantation seeks to correct severe deformities in a single operation. We report on three patients who received full-face transplants at our institution 2011 operations that aimed for functional restoration by coaptation of all main available motor and sensory nerves. enumerate the technical challenges postoperative complications their management, including episodes acute rejection two patients. At 6 months follow-up, allografts were surviving,...
Summary: Treatment of wounds has been the cornerstone plastic surgery since its inception. Vacuum-assisted closure provides a new paradigm that can be used in concert with wide variety standard existing techniques. It was originally developed as an alternative treatment for debilitated patients chronic wounds. rapidly evolved into widely accepted and acute wounds, contaminated burns, envenomations, infiltrations, wound complications from failed operations. The ease technique high rate...
Introduction Each year more than 300 000 people die from fire-related burn injuries. Millions suffer burn-related disabilities and disfigurements which have psychological, social economic effects on both the survivors their families. The burden of injury is one that falls predominantly world's poor: 95% deaths occur in low- middle-income countries (LMICs). Not only are injuries common lower socioeconomic status, but find pre-injury poverty levels worsen after recovery. Differences mortality...
In an effort to accelerate vascularization and simplify the care of Integra (Ethicon, Inc., Somerville, N.J.), topical subatmospheric pressure was used for eight patients (age range, 2 60 years) with complex wounds. Bone exposed in 62.5 percent cases, joint 50 percent, tendon 37.5 bowel 25 percent. The estimated take rate 96 Split-thickness skin grafting performed at 4 11 days (mean, 7.25 days), a 93 rate. No adverse side effects were observed this technique. Application improved time...
ABSTRACT The phenothiazines chlorpromazine (CPZ) and thioridazine (TZ) have equal in vitro activities against antibiotic-sensitive -resistant Mycobacterium tuberculosis. These compounds not been used as anti- M. tuberculosis agents because their take place at concentrations which are beyond those that clinically achievable. In addition, chronic administration of CPZ produces frequent severe side effects. Because has shown to enhance the killing intracellular medium relevant, we investigated...
Fasciotomy wounds can be a major contributor to length of stay for patients as well difficult reconstructive challenge. Once the compartment pressure has been relieved and stabilized, wound should closed quickly early possible avoid later complications. Skin grafting lead morbidity scarring at both donor fasciotomy site. Primary closure results in more functional esthetic outcome with less patient, but often achieve secondary edema, skin retraction, edge necrosis. Our objective was examine...
This review discusses the relationship of efflux pump (EP) system Gram-negative bacteria to other antibiotic resistance mechanisms bacterium such as quorum sensing, biofilms, two component regulons, etc. The genetic responses a an that render it immune are also discussed. Lastly, methods have been developed for identification over-express their EP presented in detail. Phenothiazines well-known antipsychotic drugs with reported activity against bacterial EPs and ancillary organism. Therefore...
Abstract Diterpenes occurring in plants of the Euphorbiaceae family are considerable interest context natural product drug discovery programs because their wide range potentially valuable biological activities and broad structural diversity due to different polycyclic macrocyclic skeletons various aliphatic aromatic ester groups. Euphorbia species have provided many lead compounds (resiniferatoxin, prostratin, jatrophane pepluane esters) for development, some which currently involved...
Over 1 million burn injuries are treated annually in the United States, and current tissue engineered skin fails to meet need for full-thickness replacement. Bioprinting technology has allowed fabrication of demonstrated ability close wounds. However, analysis collagen remodeling wounds with bioprinted not been reported. The purpose this study is demonstrate utility epidermal barrier formation normal Human keratinocytes, melanocytes, fibroblasts, dermal microvascular endothelial cells,...
Early excision and autografting are standard care for deeper burns. However, donor sites a source of significant morbidity. To address this, the ReCell® Autologous Cell Harvesting Device (ReCell) was designed use at point-of-care to prepare noncultured, autologous skin cell suspension (ASCS) capable epidermal regeneration using minimal skin. A prospective study conducted evaluate clinical performance ReCell vs meshed split-thickness grafts (STSG, Control) treatment deep partial-thickness...
Bioprinting is a promising alternative method to generate skin substitutes because it can replicate the structural organization of into biomimetic layers in vitro. In this study, six primary human cell types were used bioprint trilayer construct consisting epidermis, dermis, and hypodermis. Transplantation bioprinted with cells onto full-thickness wounds nu/nu mice promoted rapid vascularization formation epidermal rete ridges analogous native normal-looking extracellular matrix....
There are currently over 80 biomaterials derived from autologous, allogeneic, synthetic and xenogeneic sources, or a combination of any all these types materials, available for soft-tissue coverage to effect wound closure. Often generically referred as cellular and/or tissue-based products (CTPs), they manufactured under various trade names marketed variety indications.
Expression of eight transporter genes Escherichia coli K-12 and its DeltaacrAB mutant prior to after induction both strains tetracycline resistance reversal induced were analyzed by quantitative reverse transcriptase PCR. All overexpressed with acrF being 80-fold more expressed in the tetracycline-induced strain.