A5052477073- Synthesis and biological activity
- Antibiotic Resistance in Bacteria
- Essential Oils and Antimicrobial Activity
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemistry and Biological Activities
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Advanced Drug Delivery Systems
- Biochemical Analysis and Sensing Techniques
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Quinazolinone synthesis and applications
- Drug Transport and Resistance Mechanisms
- Biological and pharmacological studies of plants
- Advanced biosensing and bioanalysis techniques
- Genomics, phytochemicals, and oxidative stress
- Phytochemical compounds biological activities
- Antibiotics Pharmacokinetics and Efficacy
- Chemical Reactions and Isotopes
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Plant Molecular Biology Research
- RNA Interference and Gene Delivery
- Microbial Natural Products and Biosynthesis
University of Szeged
2009-2025
University of Novi Sad
2022
University of Cambridge
2008
Indian Institute of Science Bangalore
2008
Scripps Research Institute
2008
University of California, San Diego
2008
RIKEN
2008
Nagoya University
2008
University of California, Irvine
2008
Emory University
2008
Abstract The role of quorum sensing (QS) is well known in microbial pathogenicity and antibiotic resistance. QS responsible for motility, swarming, biofilm production based on the signal molecules, e.g., acylated homoserine lactones (AHLs) produced by micro‐organisms above certain population density. inhibition may reduce pathogenicity, resistance formation systemic local infections. other transmitters contribute to several bacteria; consequently signals reduces problem virulence. Due...
Origanum majorana L. is a widely used medicinal plant; its distilled oil and preparations are extensively utilised in the phytotherapy food industries. The objective of this study to evaluate extracts essential (EO) L, monoterpenes for antimicrobial, bacterial multidrug resistance reversing, biofilm formation inhibitory potency. composition EO n-hexane extract was characterized by GC-MS. In terpinen-4-ol (24.92%), trans-sabinene hydrate (25.18%), γ-terpinene (6.48%), cis-sabinene (5.44%),...
This work aimed to develop lomustine (LOM) and n-propyl gallate (PG)-loaded liposomes suitable for targeting glioblastoma multiforme (GBM) via the auspicious nose-to-brain drug delivery pathway. The therapeutical effect of LOM, as a nitrosourea compound, can be potentiated by PG enhanced anti-cancer therapy. Nose-to-brain LOM combined in overcome poor water solubility, absorption properties, toxicity issues systemic circulation. Optimization characterization liposomal carrier with binary...
Telepharmacy can improve the delivery of pharmaceutical care services to patients. However, there are limited data regarding knowledge, perceptions, and readiness (KPR) for telepharmacy in Indonesia. In this cross-sectional survey study, we assessed KPR associated factors among Indonesian pharmacists, aiming implement future.
The present study aimed to prepare and optimize lamotrigine-loaded bovine serum albumin nanoparticles (LAM-NP) using the Quality by Design (QbD) approach investigate both in vitro ex vivo effects of different cross-linking agents glutaraldehyde (GLUT), glucose (GLUC) 1-(3-dimethylaminutesopropyl)-3-ethylcarbodiimide hydrochloride (EDC) on intranasal applicability. Cross-linked LAM-NP from EDC (NP-EDC-1) showed lowest Z-average value (163.7 ± 1.9 nm) drug encapsulation efficacy (EE%) 97.31...
The multidrug resistance (MDR) proteins are present in a majority of human tumours. Their activity is important to understand the chemotherapeutic failure. A search for MDR-reversing compounds was conducted among various Betti-base derivatives tylosin. Here, we evaluate vitro and vivo P-glycoprotein (P-gp)-modulating most promising compound N-tylosil-1-α-amino-(3-bromophenyl)-methyl-2-naphthol (TBN) using MDR1 gene-transfected parental L5178 mouse lymphoma cell lines. In experiments showed...
Current study aimed to develop a spray-dried powder containing indomethacin (IND)-loaded polymeric micelles which can be administered perorally as dissolved enhance the drug release and permeability of active substance. The resulting low dense spherical particles have decreased particle size (7.21 µm) in monodisperse distribution. had nano range (130 nm) also These nanoparticulate properties high encapsulation efficiency (> 80%) lead improvement gastrointestinal fasted fed state conditions....
A new family of diterpene-type aminotriol derivatives has been synthesised from stevioside in a stereoselective manner. The key intermediate spiro-epoxide was prepared through the methyl ester allilyc diol derived steviol. oxirane ring opened with primary and secondary amines, providing versatile library aminotriols. corresponding formed by palladium-catalysed hydrogenation, an N,O-heterocyclic compound regioselective reaction. All compounds were characterised 1D- 2D-NMR techniques HRMS...
A quorum is the smallest number of people able to organize decisions concerning functional activity. Similarly microbes use chemical signal molecules make population size-dependent "decisions" by changing their gene regulations. The inhibition sensing (QS) phenothiazines and structurally related molecules, e.g. amitriptyline, promethazine, acridine orange, imipramine, promazine, diethazine, desipramine, desertomycin 5-fluorouracil as positive control was studied with Chromobacterium...
A series of novel triazole-tethered ferrocenoylamino-substituted cinchona-chalcone hybrids along with two representative benzoylamino-substituted reference compounds were prepared by three methods CuAAC chemistry. In line the limited success or complete failure attempted conversions low catalyst loadings, means DFT modeling studies, we demonstrated that a substantial part Cu(I) ions can be chelated and thus trapped in aroylamino-substituted cinchona fragment all accessible coordinating sites...
Abstract Many of the herbal extracts used in Chinese clinical medical routine inhibit growth tumor cells. In present work, 12 selected herbs were prepared with methanol, chloroform, ethyl acetate and water, effects these on multidrug resistance (MDR) P‐glycoprotein mouse lymphoma cells transfected human mdr1 gene a lung alveolar epithelial cell line investigated. The tested for antiproliferative effects, reversal MDR possible chemopreventive effect chloroform was studied expression...
Starting from gibberellic acid (GA3), a library of allo -gibberic acid-based aminoalcohols was synthesised, and their antiproliferative effects were assayed by in vitro MTT method against panel human cancer cell lines (HeLa, SiHa, A2780, MCF-7, MDA-MB-231).
The essential oils of four lines Origanum vulgare L. subsp. hirtum (Link) Ietswaart cultivated in Hungary were analysed by GC and GC-MS methods. These found to contain carvacrol, γ-terpinene p-cymene as main constituents. antimicrobial activities the various their authentic individual components tested on Gram-positive Gram-negative bacterial strains, two Saccharomyces cerevisiae strains Candida albicans strains. No difference sensitivity was between Escherichia coli, Staphylococcus...