A5023347454- Chemical Synthesis and Analysis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Synthesis of β-Lactam Compounds
- Synthesis and Biological Evaluation
- Synthesis and Catalytic Reactions
- Carbohydrate Chemistry and Synthesis
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Click Chemistry and Applications
- Synthesis and Reactions of Organic Compounds
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
- Synthesis of heterocyclic compounds
- Advanced Synthetic Organic Chemistry
- Chromatography in Natural Products
- Biochemical Analysis and Sensing Techniques
- Microfluidic and Capillary Electrophoresis Applications
- Crystallography and molecular interactions
- Chemical Reaction Mechanisms
University of Szeged
2016-2025
Hungarian Academy of Sciences
2019-2022
Ghent University
1994-2005
University of Turku
2003
Vrije Universiteit Brussel
2002
Eötvös Loránd University
1996
Water as a solvent is not only inexpensive and environmentally benign, but may allow good reactivity. The present work focuses on the application of modified Ugi reaction, i.e. four-centre three-component reaction (U-4C-3CR), in aqueous medium to construct β-lactam libraries. All attempted reactions could be successfully performed water. conditions under which precipitation process was effective were investigated; no further work-up or purification necessary. In several cases when less...
High-performance liquid chromatography-based enantioseparation of newly prepared azole analogs monoterpene lactones and amides was studied. Effects additives mobile phase composition were evaluated both in normal polar organic modes. Applying amylose tris-(3,5-dimethylphenylcarbamate) selector modes acid base found to affect the peak profiles, without significantly influencing enantiorecognition ability studied selector. In most cases, differences observed retention times...
ABSTRACT The effects of temperature on the chiral recognition cyclic β‐amino acid enantiomers zwitterionic [Chiralpak ZWIX(+) and ZWIX(–)] stationary phases were investigated. Experiments performed at different mobile phase compositions under 10°C column increments in range 10–50°C. Apparent thermodynamic parameters T iso values calculated from plots ln k α versus 1/T , respectively. Unusual behavior was observed, especially ZWIX(–) column, where application MeOH/MeCN (50/50 v/v) containing...
Abstract The reductive amination of (−)‐2‐carene‐3‐aldehyde, prepared in two steps from (−)‐perillaldehyde, furnished 2‐carene‐based allylamines. tert ‐Butyloxycarbonyl (Boc) or carbobenzyloxy (Cbz) protection the resulting amines, followed by stereoselective dihydroxylation highly stereospecific reactions with OsO 4 and subsequent deprotection, resulted N ‐benzylaminodiols, which were transformed to primary tertiary aminodiols. ‐benzyl‐ ‐(1‐phenylethyl)‐substituted derivatives formaldehyde...
Background: Gibberellins (GAs) are a family of tetracyclic ent-kaurenoid diterpenes found widely in several commonly used plants. Besides agricultural applications, gibberellins play an important role the synthesis bioactive compounds, especially those with antiproliferative and antibacterial activity. Methods: A series gibberellic acid-based 2,4-diaminopyrimidines was designed synthesized from commercially available acid. The antimicrobial activity prepared compounds also explored B....
Grossheimin, a guaiane-type sesquiterpene lactone, displayed diverse range of biological activities, including anticancer, anti-inflammatory and antimicrobial effects. Various amino analogues grossheimin were prepared through Michael addition at its highly active α-methylene-γ-lactone motif. On the other hand, was reduced to diol, which then subjected nucleophilic or acetylation introduce heteroatoms associated with oxygen, sulfur nitrogen functionalities. All synthesised acetylated adducts...
Novel peptides based on common amino acid building blocks may serve as possible drug candidates; however, their flexible structures require stabilization via the incorporation of conformational constraints. The insertion unusual acids is a feasible option that provide improved pharmacokinetic and pharmacodynamic properties such peptide-type drugs. stereochemical purity these kinds must be verified by an efficient separation technique, high-performance liquid chromatography. Here, we present...
A library of neoisopulegol-based amino and thiol adducts was developed from (+)-neoisopulegol, derived commercially available (-)-isopulegol. Michael addition different nucleophiles towards its highly active α,β-unsaturated γ-lactone motif accomplished, resulting in diverse analogs stereoselective reactions. Then, the lactone ring opened, with NH3 benzylamine furnishing primary amide N-benzyl-substituted derivatives, respectively. The vitro antimicrobial effect prepared compounds also...
The long-range side-chain repulsion between the (1R,2R,3R,5R)-2-amino-6,6-dimethyl-bicyclo[3.1.1]-heptane-3-carboxylic acid (trans-ABHC) residues stabilize H12 helix in β-peptide oligomers.
Stereoselective HPLC separations of five sterically constrained monoterpene-based 2-aminocarboxylic acid enantiomers were carried out by using the newly developed zwitterionic chiral stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™ based on Cinchona alkaloid. In order to optimize retention enantioselectivity parameters, ratio different organic solvents in mobile phase nature base additives (counter- co-ions) systematically varied. The effects structure variants analytes resolution...
A new family of diterpene-type aminotriol derivatives has been synthesised from stevioside in a stereoselective manner. The key intermediate spiro-epoxide was prepared through the methyl ester allilyc diol derived steviol. oxirane ring opened with primary and secondary amines, providing versatile library aminotriols. corresponding formed by palladium-catalysed hydrogenation, an N,O-heterocyclic compound regioselective reaction. All compounds were characterised 1D- 2D-NMR techniques HRMS...
Vascular adhesion protein-1 (VAP-1) belongs to the semicarbazide-sensitive amine oxidases (SSAOs) that convert amines into aldehydes. SSAOs are distinct from mammalian monoamine (MAOs), but their substrate specificities partly overlapping. VAP-1 has been proposed as a target for anti-inflammatory drug therapy because of its role in leukocyte endothelium. Here, we describe synthesis and vitro activities novel series selective inhibitors. In addition, molecular dynamics simulations performed...